Journal ArticleDOI
Neuroprotective diarylheptanoids from the leaves and twigs of juglans sinensis against glutamate-induced toxicity in HT22 cells.
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TLDR
A new diarylheptanoid, juglanin C(1), was isolated from the 80 % methanolic extract of the leaves and twigs of JUGLANS SINENSIS and compounds 1 and 2 significantly showed neuroprotective activities against glutamate-induced toxicity in HT22 cells.Abstract:
A new diarylheptanoid, juglanin C ( 1), was isolated from the 80 % methanolic extract of the leaves and twigs of JUGLANS SINENSIS with three known diarylheptanoids, juglanin A ( 2), juglanin B ( 3), and (5R)-5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1(4-hydroxyphenyl)-3-heptanone ( 4), using bioactivity-guided fractionation and chromatographic techniques. Among the isolated diarylheptanoids, compounds 1 and 2 significantly showed neuroprotective activities against glutamate-induced toxicity in HT22 cells. These two diarylheptanoids significantly reduced the overproduction of cellular peroxide in glutamate-injured HT22 cells. Moreover, these two diarylheptanoids significantly maintained antioxidative defense systems, including glutathione, glutathione reductase, and glutathione peroxidase, under glutamate-induced oxidative stress in HT22 cells.read more
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Chemical composition and phenolic compounds profile of cladodes from Opuntia spp. cultivars with different domestication gradient
Marizel Astello-García,Ilse Cervantes,Vimal Nair,María del Socorro Santos-Díaz,Antonio Reyes-Agüero,Françoise Guéraud,Anne Nègre-Salvayre,Michel Rossignol,Luis Cisneros-Zevallos,Ana P. Barba de la Rosa +9 more
TL;DR: Assessment of molecular composition of five Opuntia species and three different varieties of each taxonomically identified species with different domestication gradients showed that O. ficus-indica seems to fall far outside of the current domestication gradient that has been proposed, and its ancestor is still unclear.
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Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
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TL;DR: The tacrine-silibinin codrug shows high AChE and BChE inhibition, neuroprotective effects, lacks tacrine's hepatotoxicity in vitro and in vivo, and shows the same pro-cognitive effects in vivo as tacrine, being superior to the physical mixture of tacrine and silibInin in all these regards.
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Involvement of heme oxygenase-1 expression in neuroprotection by piceatannol, a natural analog and a metabolite of resveratrol, against glutamate-mediated oxidative injury in HT22 neuronal cells.
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Characterization of diarylheptanoids: An emerging class of bioactive natural products.
TL;DR: Diarylheptanoids are a class of secondary plant metabolites with a wide variety of bioactivity and research on their phytochemistry and phytoanalysis is rapidly growing and the number of identified structures bearing the aryl‐C7‐aryl skeleton is at present approaching 500.
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