Journal ArticleDOI
Neuropsychologic Findings in Hypoxemic Chronic Obstructive Pulmonary Disease
Igor Grant,Robert K. Heaton,A. John McSweeny,Kenneth M. Adams,Richard M. Timms,Richard M. Timms +5 more
TLDR
It is concluded that cerebral disturbance is common in hypoxemic COPD and may be related in part to decreased availability of oxygen to the brain.Abstract:
• As part of a six-center clinical trial of the effectiveness of continuousvnocturnal oxygen in the management of hypoxemic chronic obstructive pulmonary disease (COPD), we performed detailed neuropsychologic assessments of these patients prior to their beginning treatment. The 203 patients (age, 65 years; Pao2, 51 mm Hg; forced expiratory volume in 1 s, 0.74 L) performed significantly worse than controls on virtually all neuropsychologic tests. Moderate to severe test impairment suggestive of cerebral dysfunction was found in 42% of the patients, as compared with 14% of controls. Higher cognitive functions (abstracting ability, complex perceptual-motor integration) were most severely affected, although half the patients also showed decrements in motor speed, strength, and coordination. Low-order significant inverse correlations were found between neuropsychologic impairment and Pao2, resting arterial oxygen saturation and hemoglobin levels and maximum work. It is concluded that cerebral disturbance is common in hypoxemic COPD and may be related in part to decreased availability of oxygen to the brain. (Arch Intern Med1982;142:1470-1476)read more
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The HNRC 500-Neuropsychology of Hiv infection at different disease stages
Robert K. Heaton,Igor Grant,Nelson Butters,Desiree A. White,Donald Kirson,J. Hampton Atkinson,J. Allen McCutchan,Michael J. Taylor,Mark D. Kelly,Ronald J. Ellis,Tanya Wolfson,Robert A. Velin,Thomas D. Marcotte,John R. Hesselink,Terry L. Jernigan,James L. Chandler,Mark S. Wallace,Ian Abramson +17 more
TL;DR: HIV-related NP impairment was generally mild, especially in the medically asymptomatic stage of infection, and most often affected attention, speed of information processing, and learning efficiency; this pattern is consistent with earliest involvement of subcortical or frontostriatal brain systems.
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Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome.
Ramona O. Hopkins,Lindell K. Weaver,Donna Pope,James F. Orme,Erin D. Bigler,Valerie Larson-Lohr +5 more
TL;DR: A substantial portion of ARDS survivors exhibit impaired health status and cognitive sequelae which may be due to hypoxemia, emboli, inflammation, drug toxicity, and/or other etiologies one year after ARDS.
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Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center.
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TL;DR: It appears that even milder neurocognitive impairment reflects microneuroanatomical injury to synaptic structures.
References
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Journal ArticleDOI
A Standardized Memory Scale for Clinical Use
TL;DR: In this article, a standardized memory scale for clinical use is presented. But it is not suitable for the task of clinical evaluation. The Journal of Psychology: Vol. 19, No. 1, No 1, pp. 87-95.
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TL;DR: Why should wait for some days to get or receive the clinical neuropsychology current status and applications book that you order?
Journal Article
Life quality of patients with chronic obstructive pulmonary disease
TL;DR: In this article, the authors found that the life quality of patients with COPD was impaired relative to healthy subjects on all dimensions of life quality: emotional functioning, social role functioning, activities of daily living, and recreational pastimes.
Journal ArticleDOI
Life quality of patients with chronic obstructive pulmonary disease.
A. John McSweeny,A. John McSweeny,Igor Grant,Robert K. Heaton,Kenneth M. Adams,Richard M. Timms +5 more
TL;DR: The life quality of patients with COPD was found to be impaired relative to healthy subjects on all dimensions; depression was the preponderant emotional disturbance reported; difficulties with home management and reduction in social interaction were the primary social-role deficits.