Journal ArticleDOI
Chronic Obstructive Pulmonary Disease: An Original Model of Cognitive Decline
Raffaele Antonelli Incalzi,Antonella Gemma,Camillo Marra,Rodolfo Muzzolon,O. Capparella,Pierugo Carbonin +5 more
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TLDR
Results suggest that continuous oxygen therapy does not prevent or only partly prevents cognitive decline in COPD, and a distinct cognitive profile was found in a large fraction of patients with COPD and it differs in several aspects from those of both normal and demented subjects.Abstract:
In order to characterize the neuropsychologic profile of patients with hypoxic-hypercapnic chronic obstructive pulmonary disease (COPD), the performance of 36 patients with COPD 69 +/- 10 yr of age (mean +/- SD) on 19 tests exploring eight cognitive domains was compared with those of 29 normal adults (69 +/- 7 yr of age), 20 normal elderly adults (78 +/- 2 yr of age), 26 patients with Alzheimer-type dementia (72 +/- 6 yr of age), and 28 with multi-infarct dementia (MID) (70 +/- 8 yr of age). The discriminant analysis of cognitive test scores showed that 48.5% of patients with COPD had a specific pattern of cognitive deterioration characterized by a dramatic impairment in verbal and verbal memory tasks, well-preserved visual attention, and diffuse worsening of the other functions. The remaining patients with COPD were functionally classified as normal adults (12.1%), normal elderly adults (15.2%), those with MID (12.1%), and those with Alzheimer-type dementia (12.1%) according to discriminant analysis. Cognitive impairment was significantly and positively correlated with age (p < 0.05) and duration of hypoxic-hypercapnic chronic respiratory failure (p < 0.05). Because patients with COPD were receiving oxygen therapy from the beginning of oxyhemoglobin desaturation, results suggest that continuous oxygen therapy does not prevent or only partly prevents cognitive decline in COPD. Although some analogies between age-related and COPD-related cognitive decline are evident, a distinct cognitive profile was found in a large fraction of patients with COPD and it differs in several aspects from those of both normal and demented subjects.read more
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Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Guidelines
Andrew L. Ries,Brian W. Carlin,Virginia Carrieri-Kohlman,Richard Casaburi,Bartolome R. Celli,Charles F. Emery,John E. Hodgkin,Donald A. Mahler,Barry J. Make,Judah Skolnick +9 more
Journal ArticleDOI
Quantifying physical activity in daily life with questionnaires and motion sensors in COPD
Fabio Pitta,Thierry Troosters,Vanessa S. Probst,Martijn A. Spruit,Marc Decramer,Rik Gosselink +5 more
TL;DR: The present article aims to compare and discuss the two kinds of instruments more commonly used to quantify the amount of physical activity performed by COPD patients in daily life: subjective methods (questionnaires, diaries) and motion sensors (electronic or mechanical methods).
Journal ArticleDOI
Pulmonary rehabilitation - 1999
Suzanne C. Lareau,Richard ZuWallack,Brian W. Carlin,Bartolome R. Celli,Bonnie F. Fahy,Rik Gosselink,Paul W. Jones,Janet L. Larson,Paula Meek,Carolyn L. Rochester,DE Sassi-Dambron,D Stubbing +11 more
Journal ArticleDOI
Cognitive function in COPD
TL;DR: There may be a pattern of cognitive dysfunction specific to COPD, and cognitive function is only mildly impaired in patients without hypoxaemia, and there is limited evidence for a significant effect of treatment on cognitive function.
Journal ArticleDOI
Hypoxemia in patients with COPD: cause, effects, and disease progression.
TL;DR: Long-term oxygen therapy has been shown to improve pulmonary hemodynamics, reduce erythrocytosis, and improve survival in selected patients with severe hypoxemic respiratory failure, however, the optimal treatment for patients with exertional oxyhemoglobin desaturation, isolated nocturnal hypoxemia, or mild-to-moderate resting daytime hypoxia remains uncertain.
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