Journal ArticleDOI
New trends of progestins treatment of endometriosis.
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TLDR
The results of clinical studies on new trends of progestins in the treatment of endometriosis are presented to present the research on the development of new well-tolerated drugs.Abstract:
The management of endometriosis with OC or progestins is generally safe, effective and well-tolerated and should constitute the first line of medical treatment in symptomatic patients who do not want to have children. Progestins, synthetic progestational agents, have been used in the management of symptomatic endometriosis both as primary therapy and as an adjunct to surgical time. A variety of oral agents have been employed in this regard and investigators have demonstrated differing degrees of benefit. The lack of a standardized instrument to evaluate painful symptoms makes comparative analysis more difficult. Concern about efficacy and side effect has pushed the research on the development of new well-tolerated drugs and to develop new administration routes to minimize general side effects. Aim of the present review is to present the results of clinical studies on new trends of progestins in the treatment of endometriosis.read more
Citations
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Journal ArticleDOI
Endometriosis: Epidemiology, Diagnosis and Clinical Management
TL;DR: In this article, the authors reviewed the epidemiology of endometriosis as well as potential biomarkers for detection and with the goal of highlighting risk factors that could be used in combination with biomarkers to identify and treat women with endometrial cancer earlier.
Journal ArticleDOI
Endometriosis: where are we and where are we going?
Alexis D. Greene,Stephanie A. Lang,Jessica A. Kendziorski,Julie M Sroga-Rios,Thomas J. Herzog,Katherine A. Burns +5 more
TL;DR: The literature over the last 5 years has advanced critical knowledge related to hormones, hormone receptors, immune dysregulation, hormonal treatments, and the transformation of endometriosis to ovarian cancer with the goal of providing the reader an overview and related references for further study to highlight the progress made in endometiosis research.
Journal ArticleDOI
Estrogen-progestins and progestins for the management of endometriosis.
Paolo Vercellini,Laura Buggio,Nicola Berlanda,Giussy Barbara,Edgardo Somigliana,Silvano Bosari +5 more
TL;DR: Estrogen-progestins and progestins reduce the incidence of postoperative endometricrioma recurrence and show a protective effect against endometriosis-associated epithelial ovarian cancer risk.
Journal ArticleDOI
Adenomyosis: a systematic review of medical treatment.
Alessandro Pontis,Maurizio Nicola D'Alterio,S Pirarba,C. De Angelis,Raffaele Tinelli,Stefano Angioni +5 more
TL;DR: Medical therapies using suppressive hormonal treatments, such as continuous use of oral contraceptive pills, high-dose progestins, selective oestrogen receptor modulators, selective progesterone receptor modulator, and gonadotrophin receptor hormone agonists can temporarily induce regression of adenomyosis and improve the symptoms.
Journal ArticleDOI
Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis
TL;DR: Regular and prolonged medication until the patient wishes to conceive is highly recommended to prevent the postoperative recurrence of endometriosis.
References
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Journal ArticleDOI
Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis
Carlos Alberto Petta,Rui Alberto Ferriani,Mauricio Simões Abrão,Daniela Fink Hassan,Júlio César Rosa e Silva,Sergio Podgaec,Luis Bahamondes +6 more
TL;DR: Both the LNG-IUS and the GnRH-analogue were effective in the treatment of CPP-associated endometriosis, although no differences were observed between the two treatments.
Journal ArticleDOI
Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial.
TL;DR: Dienogest 2 mg/day orally demonstrated equivalent efficacy to depot LA at standard dose in relieving the pain associated with endometriosis, although offering advantages in safety and tolerability.
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Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis
TL;DR: Insertion of a levonorgestrel-releasing IUD alleviates pain and reduces the size of lesions in patients with endometriosis of the rectovaginal septum in a prospective therapeutic non-randomized, self-controlled clinical trial.
Journal ArticleDOI
Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study
Paolo Vercellini,Giada Frontino,Olga De Giorgi,Giorgio Aimi,Barbara Zaina,Pier Giorgio Crosignani +5 more
TL;DR: Insertion of an Lng-IUD after laparoscopic surgery for symptomatic endometriosis significantly reduced the medium-term risk of recurrence of moderate or severe dysmenorrhea.
Journal ArticleDOI
Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial
Tasuku Harada,Mikio Momoeda,Yuji Taketani,Takeshi Aso,Masao Fukunaga,Hiroshi Hagino,Naoki Terakawa +6 more
TL;DR: Dienogest is as effective as intranasal BA in alleviating endometriosis, and causes less BMD loss.