Girolamo Calò

TL;DR: How NOP pharmacology intersects, contrasts, and interacts with the mu opioid receptor in terms of tertiary structure and mechanism of receptor activation; location of receptors in the central nervous system; mechanisms of desensitization and downregulation; cellular actions; intracellular signal transduction pathways; and behavioral actions with respect to analgesia, tolerance, dependence, and reward is discussed.

TL;DR: The Concise Guide to PHARMACOLOGY 2021/22 as mentioned in this paper provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands.

TL;DR: In this article, a review summarizes the available information on TAR1 from different insect species in terms of basic structure, its regulation and signal transduction mechanisms, and its distribution and functions in the brain and the periphery.

TL;DR: In this article, a novel ATTO488 based fluorescent Dermorphin analogue, DermATTO488 (Derm-NH2), was developed to detect the location of the μ-opioid peptide (MOP) receptor.

TL;DR: In this paper, the authors investigated the in vitro and in vivo pharmacodynamic profile of 1-cyclohexyl-x-methoxybenzene derivatives and compared them with those caused by tramadol and phencyclidine.