Journal ArticleDOI
NORAD Expression Is Associated with Adverse Prognosis in Esophageal Squamous Cell Carcinoma.
Xiaoliang Wu,Zuan-Fu Lim,Zhongwen Li,Ling Gu,Wenjuan Ma,Qianghua Zhou,Huifang Su,Xing Wang,Xianzi Yang,Zhenfeng Zhang +9 more
TLDR
The data indicate that increased NORAD expression might serve as a novel molecular predictor of poor prognosis in ESCC patients and maybe a potential target for diagnosis and gene therapy.Abstract:
Background: NORAD (non-coding RNA-activated by DNA damage) is a conserved, abundant, and broadly expressed long non-coding RNA, which functions to preserve genomeread more
Citations
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Journal ArticleDOI
Emerging roles of long non-coding RNA in cancer.
TL;DR: This article aims to outline different cancer‐associated lncRNA according to their contribution to tumor suppression or tumor promotion based on their most current functional annotations.
Journal ArticleDOI
LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P
Boon Shing Tan,Min Chi Yang,Min Chi Yang,Shaifali Singh,Shaifali Singh,Yu Chi Chou,Hsin Yi Chen,Ming-Yang Wang,Yi Ching Wang,Ruey-Hwa Chen,Ruey-Hwa Chen +10 more
TL;DR: It is shown that lncRNA NORAD is downregulated in lung and breast cancers, and that NORAD low expression in these cancer types is associated with lymph node metastasis and poor prognosis.
Journal ArticleDOI
The Functions and Unique Features of LncRNAs in Cancer Development and Tumorigenesis.
Kenzui Taniue,Nobuyoshi Akimitsu +1 more
TL;DR: In this paper, the authors describe the biogenesis and features of long noncoding RNAs (lncRNAs), which are transcripts longer than 200 nucleotides that lack protein-coding potential, are an important class of RNA molecules that are involved in a variety of biological functions.
Journal ArticleDOI
Long noncoding RNA XIST promotes malignancies of esophageal squamous cell carcinoma via regulation of miR-101/EZH2
Xiaoliang Wu,Xiaoxiao Dinglin,Xing Wang,Wen Luo,Qi Shen,Yong Li,Ling Gu,Qianghua Zhou,Haotu Zhu,Yanjie Li,Chaodi Tan,Xianzi Yang,Zhenfeng Zhang,Zhenfeng Zhang +13 more
TL;DR: Conclusively, XIST plays an important role in malignant progression of ESCC via modulation of miR-101/EZH2 axis through inhibition, migration and invasion of esophageal squamous cancer cells in vitro and suppressed tumor growth in vivo.
Journal ArticleDOI
Noncoding RNA activated by DNA damage (NORAD): Biologic function and mechanisms in human cancers.
TL;DR: The biologic function and mechanisms of NORAD in human cancers are systematically reviewed here to provide new directions for future research.
References
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