Journal ArticleDOI
Normalization of obesity-associated insulin resistance through immunotherapy
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This article is published in Yearbook of Endocrinology.The article was published on 2010-01-01. It has received 699 citations till now. The article focuses on the topics: Normalization (statistics) & Insulin resistance.read more
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Adipokines in inflammation and metabolic disease
TL;DR: The role of adipokines in inflammatory responses is focused on and their potential as regulators of metabolic function is discussed.
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Functional interactions between the gut microbiota and host metabolism
TL;DR: Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, the world will be in a better position to develop treatments for metabolic disease.
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Inflammatory Mechanisms in Obesity
TL;DR: The discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a research field that examines the inflammatory mechanisms in obesity, and metaflammation is summarized, defined as low-grade, chronic inflammation orchestrated by metabolic cells in response to excess nutrients and energy.
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Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
TL;DR: The endoplasmic reticulum is the major site in the cell for protein folding and trafficking and is central to many cellular functions and is emerging as a potential site for the intersection of inflammation and metabolic disease.
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Regulatory T Cells: Mechanisms of Differentiation and Function
TL;DR: Cellular and molecular mechanisms in the differentiation and function of regulatory T cells and their role in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation are discussed.
References
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Journal ArticleDOI
Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.
Journal ArticleDOI
Normalization of obesity-associated insulin resistance through immunotherapy.
Shawn Winer,Yin Chan,Geoffrey Paltser,Dorothy Truong,Hubert Tsui,Jasmine Bahrami,Ruslan Dorfman,Yongqian Wang,Julian Zielenski,Fabrizio G. Mastronardi,Yuko Maezawa,Daniel J. Drucker,Edgar G. Engleman,Daniel A. Winer,H.-Michael Dosch +14 more
TL;DR: It is discovered that CD4+ T lymphocytes, resident in visceral adipose tissue (VAT), control insulin resistance in mice with diet-induced obesity (DIO), andalyses of human tissue suggest that a similar process may also occur in humans.
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Cytokine Biomarkers, Endothelial Inflammation, and Atherosclerosis in the Metabolic Syndrome: Emerging Concepts
TL;DR: Unraveling the role of emerging proinflammatory markers has the promising potential to shed light into the underlying pathophysiology of the epidemic of obesity and the metabolic syndrome and thus help devise effective therapies.