Novel aspects of brown adipose tissue biology
Joerg Heeren,Heike Münzberg +1 more
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TLDR
Several of the novel molecular genetic tools available now, compared with 40 years ago, will be helpful to gain new insights in BAT-controlled energy homeostasis and promises new approaches to pharmacologically control body weight.About:
This article is published in Endocrinology and Metabolism Clinics of North America.The article was published on 2013-03-01 and is currently open access. It has received 31 citations till now. The article focuses on the topics: Brown adipose tissue & White adipose tissue.read more
Citations
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Journal ArticleDOI
Adipose tissue browning and metabolic health
Alexander Bartelt,Joerg Heeren +1 more
TL;DR: Stimulating the development of beige adipocytes in WAT (so called 'browning') might reduce adverse effects of WAT and could help to improve metabolic health, as well as inspire new avenues to increase the capacity for adaptive thermogenesis.
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NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
Kali Chrysovergis,Xingya Wang,Justin Kosak,Seong-Ho Lee,Jong Sik Kim,Julie F. Foley,Greg Travlos,Shubha Singh,Seung Joon Baek,Thomas E. Eling +9 more
TL;DR: Transgenic hNAG-1 mice have less white fat and brown fat despite equivalent food intake, improved glucose tolerance, lower insulin levels and are resistant to dietary- and genetic-induced obesity.
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Metabolic interplay between white, beige, brown adipocytes and the liver
Ludger Scheja,Joerg Heeren +1 more
TL;DR: The role of hepatic factors that regulate the metabolic activity of white and thermogenic adipocytes are emphasized and the relevance of lipids and hormones that are secreted by white, brown and beige adipocytes regulating liver metabolism in order to maintain systemic energy metabolism in health and disease is discussed.
Journal ArticleDOI
How the association between obesity and inflammation may lead to insulin resistance and cancer.
Mohammad Nurul Amin,Mohammad Nurul Amin,Md. Saddam Hussain,Md. Shahid Sarwar,Md. Mizanur Rahman Moghal,Abhijit Das,Mohammad Zahid Hossain,Jakir Ahmed Chowdhury,Md. Shalahuddin Millat,Mohammad Safiqul Islam +9 more
TL;DR: The evidence of how obesity and inflammation may lead to insulin resistance and cancer is reviewed to reconnoiters the mechanisms that link obesity to numerous disorders such as inflammation, diabetes, cancers and most specifically combine these processes in a single image.
Journal Article
Human brown adipose tissue
TL;DR: The BAT organ is unique in that it has evolved to safely dissipate large amounts of chemical energy--a quality that might be harnessed to help humans deal with a dangerously hypercaloric environment and still remain in good health.
References
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Handbook of Physiology.
TL;DR: This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology.
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Central nervous system control of food intake
TL;DR: A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.
Journal ArticleDOI
Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
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Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
TL;DR: Cloned cDNA encoding Osf2/Cbfa1 is identified as an osteoblast-specific transcription factor and as a regulator of osteoblasts differentiation.
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Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
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