Novel functions for Period 3 and Exo-rhodopsin in rhythmic transcription and melatonin biosynthesis within the zebrafish pineal organ
Reads0
Chats0
TLDR
It is found that the transcription factor Orthodenticle homeobox 5 (Otx5) activates exorh transcription, while the putative circadian clock component Period 3 (Per3) represses expression during the day, thereby contributing to the rhythm of transcription.About:
This article is published in Brain Research.The article was published on 2008-08-05 and is currently open access. It has received 62 citations till now. The article focuses on the topics: Light effects on circadian rhythm & Pinealocyte.read more
Citations
More filters
Journal ArticleDOI
It’s time to swim! Zebrafish and the circadian clock
TL;DR: The work that has established the zebrafish as a valuable clock model organism is reviewed and the key questions that will shape the future direction of research are highlighted.
Journal ArticleDOI
Effect of lighting conditions on zebrafish growth and development.
TL;DR: Light conditions are crucial factors influencing zebrafish larval development and growth, and the results revealed that the hatching rate was highest under blue and violet light, while total length was greatest under blue, white, and Violet light.
Journal ArticleDOI
Circadian rhythmicity and light sensitivity of the zebrafish brain.
Helen A. Moore,David Whitmore +1 more
TL;DR: In this paper, the authors used period3 (per3)-luciferase transgenic zebrafish to confirm that multiple brain regions contain endogenous circadian oscillators that are directly light responsive.
Book ChapterDOI
Circadian clocks: lessons from fish.
M. Laura Idda,Cristiano Bertolucci,Daniela Vallone,Yoav Gothilf,Francisco Javier Sánchez-Vázquez,Nicholas S. Foulkes +5 more
TL;DR: The zebrafish was initially considered as a potentially attractive genetic model for identifying vertebrate clock genes but instead, fish have ultimately proven to be valuable complementary models for studying various aspects of clock biology.
Journal ArticleDOI
Effects of LED light spectra on oxidative stress and the protective role of melatonin in relation to the daily rhythm of the yellowtail clownfish, Amphiprion clarkii
TL;DR: The results indicate that red light induces oxidative stress and melatonin plays the role of a strong antioxidant in yellowtail clownfish.
References
More filters
Journal ArticleDOI
Effective targeted gene ‘knockdown’ in zebrafish
TL;DR: It is shown here that antisense, morpholino-modified oligonucleotides (morpholinos) are effective and specific translational inhibitors in zebrafish, and conserved vertebrate processes and diseases are now amenable to a systematic, in vivo, reverse-genetic paradigm using zebra fish embryos.
Journal ArticleDOI
Molecular Analysis of Mammalian Circadian Rhythms
TL;DR: Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing.
Journal ArticleDOI
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
David L. Turner,Harold Weintraub +1 more
TL;DR: Analysis of molecular markers for neural, epidermal, and neural crest cells indicates that CNS expansion occurs as early as neural plate formation, and inhibition of DNA synthesis shows that additional CNS tissue does not depend on cell division--rather it reflects conversion of prospective neural crest andEpidermal cells to a neural fate.
Journal ArticleDOI
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
Journal ArticleDOI
Xenopus embryos regulate the nuclear localization of XMyoD.
TL;DR: This work postulates that XMyoD is under negative control in frog embryos, but because of slight sequence differences, mouse MyoD fails to see the negative signal, and suggests that muscle induction might remove this negative regulation, allow MyOD to enter the nucleus, and establish an autoregulatory loop that could commit cells to myogenesis.