Novel opportunities and challenges offered by nanobiomaterials in tissue engineering.
TLDR
A detailed overview of the advantages, applications, and limitations of nanostructured matrices with a focus on both electrospun and self-assembling scaffolds is presented.Abstract:
Over the last decades, tissue engineering has demonstrated an unquestionable potential to regenerate damaged tissues and organs. Some tissue-engineered solutions recently entered the clinics (eg, artificial bladder, corneal epithelium, engineered skin), but most of the pathologies of interest are still far from being solved. The advent of stem cells opened the door to large-scale production of "raw living matter" for cell replacement and boosted the overall sector in the last decade. Still reliable synthetic scaffolds fairly resembling the nanostructure of extracellular matrices, showing mechanical properties comparable to those of the tissues to be regenerated and capable of being modularly functionalized with biological active motifs, became feasible only in the last years thanks to newly introduced nanotechnology techniques of material design, synthesis, and characterization. Nanostructured synthetic matrices look to be the next generation scaffolds, opening new powerful pathways for tissue regeneration and introducing new challenges at the same time. We here present a detailed overview of the advantages, applications, and limitations of nanostructured matrices with a focus on both electrospun and self-assembling scaffolds.read more
Citations
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Engineering hydrogels as extracellular matrix mimics
TL;DR: The progress of the current state-of-the-art engineering methods to create cell-encapsulating hydrogel tissue constructs as well as their applications in in vitro models in biomedicine are detailed.
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Applications of electrospun nanofibers
TL;DR: In this paper, a review summarizes the recent progress in electrospun nanofibers, with an emphasis on their applications, and summarizes the functionalities and surface chemistry of the polymer itself.
Journal ArticleDOI
Transplantation of Nanostructured Composite Scaffolds Results in the Regeneration of Chronically Injured Spinal Cords
Fabrizio Gelain,Silvia Panseri,Stefania Antonini,Carla Cunha,Matteo Donegà,Joseph L. Lowery,Francesca Taraballi,Gabriella Cerri,Marcella Montagna,Fausto Baldissera,Angelo L. Vescovi +10 more
TL;DR: By engineering nanostructured matrices into neuroprosthetics, it is possible to recreate an anatomical, structural, and histological framework, which leads to the replacement of large, hollow tissue gaps in the chronically injured spinal cord, fostering axonal regeneration and neurological recovery.
Book
One-Dimensional nanostructures : Electrospinning Technique and Unique Nanofibers
Zhenyu Li,Ce Wang +1 more
TL;DR: In this paper, the effects of working parameters on Electrospinning are discussed and applications of Electrospun Nanofibers properties are discussed, as well as their applications in various applications.
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Electrospun chitosan-graft-poly (ɛ-caprolactone)/poly (ɛ-caprolactone) nanofibrous scaffolds for retinal tissue engineering
TL;DR: Results suggest that CS-PCL/PCL(20/80) scaffolds have potential application in retinal tissue engineering.
References
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