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Obesity and Type 2 Diabetes: Two Diseases with a Need for Combined Treatment Strategies - EASO Can Lead the Way.

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TLDR
Therapeutic strategies are warranted, which can be easily used for the management of obese patients with type 2 diabetes to achieve their glycemic and weight loss goals.
Abstract
Obesity is a chronic metabolic disease affecting adults and children worldwide. It has become one of the leading causes of death, as obesity is known to be the main risk factor for a number of non-communicable diseases, in particular type 2 diabetes. This close relationship led to the connotation 'diabesity', highlighting the fact that the majority of individuals with diabetes are overweight or obese. Until today the BMI is still used to classify overweight and obesity. Since reduced muscle mass is highly prevalent throughout the BMI range, the measurement of body composition is strongly recommended. Moreover, it is essential for monitoring the course of weight reduction, which is part of every effective anti-obesity treatment. Weight reduction can be achieved via different weight loss strategies, including lifestyle intervention (diet and exercise), pharmacotherapy, or bariatric surgery. However, not all of these strategies are suitable for all patients, and any further needs should be considered. Besides, attention should also be drawn to concomitant therapies. These therapies may promote additional weight gain and further trigger the deterioration of blood glucose control. Thus, therapeutic strategies are warranted, which can be easily used for the management of obese patients with type 2 diabetes to achieve their glycemic and weight loss goals.

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Journal ArticleDOI

Gut microbiome and type 2 diabetes: where we are and where to go?

TL;DR: The published literature was reviewed for better understanding of the dynamics of gut microbiota, factors that potentially induce gut microbiome dysbiosis and their relation to the progression of T2D, and special emphasis was given to understand the gut microbiome induced breaching of intestinal barriers and/or tight junctions and their connection to insulin resistance.
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Diet and exercise in the prevention and treatment of type 2 diabetes mellitus.

TL;DR: This Review highlights the evidence from clinical trials that diet-induced weight loss interventions can be used to treat type 2 diabetes mellitus and preliminary work suggests that pretreatment glycaemic status could be use to stratify patients in order to optimize dietary recommendations.
Journal ArticleDOI

Marine Collagen as A Promising Biomaterial for Biomedical Applications

TL;DR: This review focuses on the expanding role of marine collagen (MC)-based scaffolds for biomedical applications, and holds great promise as a biomaterial for developing medical products and therapeutics.
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Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model.

TL;DR: Transfer of caecal viral communities from mice with a lean phenotype into mice with an obese phenotype led to reduced weight gain and normalised blood glucose parameters relative to lean mice, hypothesized to be mediated via FVT-induced GM changes.
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Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

TL;DR: The aim of the present review is to summarise the current knowledge about the beneficial effects reported for edible seaweed polyphenols in the amelioration of these prevalent conditions, focusing on both preclinical and clinical studies.
References
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Journal ArticleDOI

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

TL;DR: In this paper, the authors compared a lifestyle intervention with metformin to prevent or delay the development of Type 2 diabetes in nondiabetic individuals. And they found that the lifestyle intervention was significantly more effective than the medication.
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Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies.

Chizuru Nishida
- 10 Jan 2004 - 
TL;DR: The proportion of Asian people with a high risk of type 2 diabetes and cardiovascular disease is substantial at BMIs lower than the existing WHO cut-off point for overweight (> or =25 kg/m2), but available data do not necessarily indicate a clear BMI cut-offs point for all Asians for overweight or obesity.
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Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.
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Global burden of obesity in 2005 and projections to 2030

TL;DR: Overweight and obesity are important clinical and public health burdens worldwide and national programs for the prevention and treatment of overweight, obesity and related comorbidities and mortalities should be a public health priority.
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