One-pot thiol-free synthetic approach to sulfides, and sulfoxides selectively
TLDR
In this article , a facile and efficient thiol-free one-pot method for direct synthesis of sulfides and sulfoxides under green conditions without using any metal catalyst is reported.Abstract:
A facile and efficient thiol-free one-pot method for direct synthesis of sulfides and sulfoxides under green conditions without using any metal catalyst is reported. For this purpose, we used benzyl bromides as starting materials in the presence of potassium thioacetate (PTA) and Oxone® which are low-cost, and readily accessible chemicals. This method is highly compatible with a variety of functional groups and delivered a series of sulfides, bis-sulfides, and sulfoxides in good yields. The selective formation of sulfoxides over sulfones is discussed via a mechanism.read more
Citations
More filters
Journal ArticleDOI
Thiol‐Free E‐Selective Approach to Dithiacyclophanes via Ring‐Closing Metathesis
Journal ArticleDOI
Selectivity: A Goal for Synthetic Economy
TL;DR: In this article , a plethora of reactions that demonstrate their efforts in exploiting interesting cases of selectivity observed in the past three decades are discussed, among them, chemoselectivity, regioselectivities, steric factors, and separations of the reacting functionalities.
References
More filters
Journal ArticleDOI
Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry
TL;DR: Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades.
Journal ArticleDOI
Data-mining for sulfur and fluorine: an evaluation of pharmaceuticals to reveal opportunities for drug design and discovery.
TL;DR: The evolution and structural diversity of sulfur and the popular integration of fluorine into drugs introduced over the past 50 years are evaluated and promoted to promote innovative insights into drug development.
Journal ArticleDOI
Analysis of US FDA-Approved Drugs Containing Sulfur Atoms.
Kevin A. Scott,Jon T. Njardarson +1 more
TL;DR: This review offers a unique and comprehensive overview of the structural features of all sulfur-containing FDA-approved drugs to date.
Journal ArticleDOI
Bond-Forming and -Breaking Reactions at Sulfur(IV): Sulfoxides, Sulfonium Salts, Sulfur Ylides, and Sulfinate Salts.
TL;DR: This review aims to cover the developments of the past decade in the chemistry of organic sulfur(IV) molecules and provide insight into both the wide range of reactions which critically rely on this versatile element and the diverse scaffolds that can thereby be synthesized.
Journal ArticleDOI
Organic semiconductors based on [1]benzothieno[3,2-b][1]benzothiophene substructure.
TL;DR: BTBT derivatives and their related materials, including dinaphtho[2,3-b:2',3'-f]thieno[3,2-b]thiophene (DNTT), have turned out to be superior organic semiconductors, affording OFETs with very high mobilities.
Related Papers (5)
The base-catalysed oxidation of aliphatic and aromatic thiols and disulphides to sulphonic acids
T.J. Wallace,A. Schriesheim +1 more
Reactions of S-acylisothioureas. II. Effects of structure and stereochemistry on the rates of hydrolysis, thiol elimination, and S to N acyl migration in acylic systems
R. F. Pratt,Thomas C. Bruice +1 more