Journal ArticleDOI
Optical imaging module for astigmatic detection system.
Wei-Min Wang,Wei-Min Wang,Chung-Hsiang Cheng,Chung-Hsiang Cheng,Gabor Molnar,Ing-Shouh Hwang,Kuang-Yuh Huang,Hans-Ulrich Danzebrink,En-Te Hwu +8 more
TLDR
An optical imaging module design for an astigmatic detection system (ADS) based on a commercial optical pickup unit (OPU) and it contains a coaxial illuminant for illuminating a specimen that has the potential to be used in high-speed atomic force microscopy.Abstract:
In this paper, an optical imaging module design for an astigmatic detection system (ADS) is presented. The module is based on a commercial optical pickup unit (OPU) and it contains a coaxial illuminant for illuminating a specimen. Furthermore, the imaging module facilitates viewing the specimen and the detection laser spot of the ADS with a lateral resolution of approximately 1 μm without requiring the removal of an element of the OPU. Two polarizers and one infrared filter are used to eliminate stray laser light in the OPU and stray light produced by the illuminant. Imaging modules designed for digital versatile disks (DVDs) and Blu-ray DVDs were demonstrated. Furthermore, the module can be used for imaging a small cantilever with approximate dimensions of 2 μm (width) × 5 μm (length), and therefore, it has the potential to be used in high-speed atomic force microscopy.read more
Citations
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Journal ArticleDOI
Hacking CD/DVD/Blu-ray for Biosensing
Edwin En-Te Hwu,Anja Boisen +1 more
TL;DR: This review details the OPU mechanism and components, and discusses scientific research using OPUs, from standard optical drive-based turnkey-biomarker array reading and OPU direct bioapplications to modified OPU-based biosensing (DNA chip fluorescence scanning, biomolecular diagnostics).
Journal ArticleDOI
Imaging initial formation processes of nanobubbles at the graphite–water interface through high-speed atomic force microscopy
TL;DR: In this paper, an astigmatic high-speed atomic force microscope (AFM) was modified to enable imaging in the liquid environment, which yielded highly dynamic quasi-two-dimensional (2D) gas structures initially at the graphite-water interface.
Journal ArticleDOI
Micropipette Resonator Enabling Targeted Aspiration and Mass Measurement of Single Particles and Cells.
TL;DR: Micropipette resonators, mechanical resonator integrated micropipettes, which enable selective aspiration and mass measurement for particles or cells suspended in liquid with two orthogonal vibration modes are reported.
Journal ArticleDOI
Low-cost, open-source XYZ nanopositioner for high-precision analytical applications
Hsien-Shun Liao,C Chris Werner,Roman Slipets,Peter Emil Larsen,Ing-Shouh Hwang,Tien-Jen Chang,Hans Ulrich Danzebrink,Kuang-Yuh Huang,En T. Hwu +8 more
TL;DR: In this article , an open-source XYZ-axis nanopositioning system is presented, which uses a magnet-based stick-slip driving mechanism to achieve sub-nanometer resolution, a payload capacity of up to 12 kg (horizontal), and easy assembly.
Journal ArticleDOI
Open-source controller for low-cost and high-speed atomic force microscopy imaging of skin corneocyte nanotextures
Hsien-Shun Liao,Imtisal Akhtar,C Chris Werner,Roman Slipets,J. Pereda,Jen-Hung Wang,Ellen Raun,Laura Olga Nørgaard,F. Dons,Edwin En-Te Hwu +9 more
TL;DR: In this article , an open-source HS-AFM controller was proposed to achieve a maximum tip-sample velocity of 5,093 µm/s (9.3 s/frame, 512 × 512 pixels), which is nearly 100 times higher than that of the original controller.
References
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Journal ArticleDOI
Measurement of Cantilever Displacement Using a Compact Disk/Digital Versatile Disk Pickup Head
TL;DR: In this paper, the optical pickup head of a commercial compact disk (CD)/digital versatile disk (DVD) read only memory (ROM) drive was used to detect the vertical displacement of micro fabricated cantilever in atomic force microscopy (AFM).
Journal ArticleDOI
Simultaneous detection of translational and angular displacements of micromachined elements
TL;DR: In this article, an astigmatic detection system is constructed with a modified digital-versatile-disk optical head, with a detecting spot of ∼1μm, which can simultaneously measure the vertical displacements and two-dimensional angular tilts of micromachined elements.
Journal ArticleDOI
Development of a high-precision straightness measuring system with DVD pick-up head
TL;DR: In this article, a low-cost and high-precision straightness measurement system using a DVD pick-up head has been developed in which a moving knife-edge piece is placed between the pickup head and a plane mirror.
Journal ArticleDOI
Real-time detection of linear and angular displacements with a modified DVD optical head
TL;DR: It is demonstrated that an astigmatic detection system (ADS), constructed with a modified digital-versatile-disk (DVD) optical head, can achieve real-time measurement of a linear displacement and two-dimensional tilt angles with a high sensitivity.
Journal ArticleDOI
High throughput label-free platform for statistical bio-molecular sensing.
Filippo Bosco,En-Te Hwu,Ching-Hsiu Chen,Stephan Sylvest Keller,Michael Bache,Mogens Jakobsen,Ing-Shouh Hwang,Anja Boisen +7 more
TL;DR: The demonstration of a high-throughput label-free sensor platform utilizing cantilever based sensors using optics and mechanics from a DVD player to handle liquid samples and to read-out Cantilever deflection and resonant frequency.