Journal ArticleDOI
Optimization of media by evolutionary algorithms for production of polyols
TLDR
A new, real coded evolutionary algorithm was developed for optimization of fermentation medium in parallel shake-flask experiments, which obtains the optimal values of important process variables, namely, inoculum size and sugar, yeast extract, urea, and MgSO4 concentrations.Abstract:
Biotransformation of sucrose-based medium to polyols has been reported for the first time using osmophilic yeast, Hansenula anomala A new, real coded evolutionary algorithm was developed for optimization of fermentation medium in parallel shake-flask experiments By iteratively employing the nature-inspired techniques of selection, crossover, and mutation for a fixed number of generations, the algorithm obtains the optimal values of important process variables, namely, inoculum size and sugar, yeast extract, urea, and MgSO4 concentrations Maximum polyols yield of 7643% has been achieved The method is useful for reducing the overall development time to obtain an efficient fermentation processread more
Citations
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Journal ArticleDOI
Optimization of a fermentation medium using neural networks and genetic algorithms
Yuko Nagata,Khim Hoong Chu +1 more
TL;DR: Using this procedure, two artificial intelligence techniques have been effectively integrated to create a powerful tool for process modeling and optimization in Agrobacterium radiobacter.
Journal ArticleDOI
Potential of fermentation profiling via rapid measurement of amino acid metabolism by liquid chromatography-tandem mass spectrometry.
TL;DR: Correlation coefficients for the time profiles of each amino acid measured illustrate that while several amino acids are differentially metabolized in similar fermentations, a select group of amino acids display strong correlations in these samples, indicating a sub-population of analytes that may be most useful for fermentation profiling.
Journal ArticleDOI
Effect of medium osmolarity on the bioproduction of glycerol and ethanol by Hansenula anomala growing on glucose and ammonium
TL;DR: The osmotolerant yeast Hansenula anomala survives in media at low water activity resulting from increasing NaCl concentrations in the culture medium by producing compatible solutes and was clearly related to another mechanism other than osmotic: it was excreted by a fermentative mechanism to ensure energy for cell maintenance.
Journal ArticleDOI
Maximizing microbial degradation of perchlorate using a genetic algorithm: Media optimization
TL;DR: Comparison of zero-order kinetic rate constants for environmental conditions in GA-determined first and last generations of all bacterial cultures additionally showed marked increases, including marked increases in perchlorate degradation rates for two bacterial consortia.
Journal ArticleDOI
Improvement of erythrose reductase activity, deletion of by-products and statistical media optimization for enhanced erythritol production from Yarrowia lipolytica mutant 49.
TL;DR: In order to enhance erythritol production, the three component-three level-one response Box–Behnken of response surface methodology model was used and the optimum medium composition was found to be (g/l) glucose 279, ammonium sulfate 9.28, and pH 5.76.
References
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Book
Genetic Algorithms + Data Structures = Evolution Programs
TL;DR: GAs and Evolution Programs for Various Discrete Problems, a Hierarchy of Evolution Programs and Heuristics, and Conclusions.
Journal ArticleDOI
Medium Optimization by Genetic Algorithm for Continuous Production of Formate Dehydrogenase
Dirk Weuster-Botz,C. Wandrey +1 more
TL;DR: A continuous production process for formate dehydrogenase (FDH) production by the methylotrophic yeast Candida boidinii was improved by medium optimization in parallel shake-flask experiments by using a genetic algorithm.
Journal ArticleDOI
Optimization of medium composition for the production of glucosyltransferase by Aspergillus niger with response surface methodology
Shiow-Ling Lee,Wen-Chang Chen +1 more
TL;DR: Aspergillus niger CCRC 31494 produced an extracellular glucosyltransferase (EC 2.4.1.24) with a high transglucosylating activity and yeast extract was the best nitrogen source after cultivation for 7 days.
Journal ArticleDOI
Artificial neural network based experimental design procedure for enhancing fermentation development.
TL;DR: A general strategy using artificial neural networks as an alternative approach to fermentation process development laboratory are presented for the neural network based procedures.