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Organotin polymers as anticancer and antiviral agents
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TLDR
Organotin polymers are easily synthesized employing interfacial polymerization systems involving the reaction of difunctional Lewis bases and organotin halides and have been shown to exhibit a wide range of biological activities including the inhibition of a wide variety of cancer cell lines including cell lines associated with ovarian, colon, lung, prostrate, pancreatic and breast cancer as mentioned in this paper.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 112 citations till now.read more
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An overview of functional nanoparticles as novel emerging antiviral therapeutic agents.
Lu Chen,Jiangong Liang +1 more
TL;DR: This topic review covers 132 papers and will enrich knowledge about the antiviral efficacy and mechanism of various functional nanoparticles and the challenges and prospects of antiviral nanostructures.
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Rational Co-Design of Polymer Dielectrics for Energy Storage.
Arun Mannodi-Kanakkithodi,Gregory M. Treich,Tran Doan Huan,Rui Ma,Mattewos Tefferi,Yang Cao,Gregory A. Sotzing,Rampi Ramprasad +7 more
TL;DR: In this article, a rational co-design approach for polymer dielectric design for electrostatic energy storage applications is presented. And the challenges that remain and the need for additional methodological developments necessary to further strengthen the concept are then presented.
Journal Article
Rational Co-Design of Polymer Dielectrics for Energy Storage
TL;DR: It is illustrated here how one may harness a rational co-design approach-involving synergies between high-throughput computational screening and experimental synthesis and testing-with the example of polymer dielectrics design for electrostatic energy storage applications.
Journal ArticleDOI
DFT calculations on molecular structures, HOMO–LUMO study, reactivity descriptors and spectral analyses of newly synthesized diorganotin(IV) 2‐chloridophenylacetohydroxamate complexes
TL;DR: The gas‐phase‐optimized geometry of newly synthesized and characterized diorganotin(IV) 2‐chloridophenylacetohydroxamate complexes of composition and the computed vibrational frequencies and 1H NMR chemical shifts have substantiated the molecular structure of complexes.
Journal ArticleDOI
Organo-tin antitumor compounds: Their present status in drug development and future perspectives
TL;DR: The progress made in the past decade by organotin compounds as antitumor chemotherapeutic agents is reflected and the landmarks for their future projections in drug industry are explored.
References
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Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Peng Li,Deepak Nijhawan,Imawati Budihardjo,Srinivasa M. Srinivasula,Manzoor Ahmad,Emad S. Alnemri,Xiaodong Wang +6 more
TL;DR: Mutation of the active site of caspase-9 attenuated the activation of cazase-3 and cellular apoptotic response in vivo, indicating that casp enzyme-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.
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Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
TL;DR: The results indicate that BID is a mediator of mitochondrial damage induced by Casp8, and coexpression of BclxL inhibits all the apoptotic changes induced by tBID.
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Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
TL;DR: The purification of a cytosolic protein that induces cytochrome c release from mitochondria in response to caspase-8, the apical caspases activated by cell surface death receptors such as Fas and TNF is reported.
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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
Masato Enari,Hideki Sakahira,Hideki Yokoyama,Katsuya Okawa,Akihiro Iwamatsu,Shigekazu Nagata,Shigekazu Nagata +6 more
TL;DR: A caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD) have now been identified in the cytoplasmic fraction of mouse lymphoma cells and seems to function as a chaperone for CAD during its synthesis, remaining complexed with CAD to inhibit its DNase activity.
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The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.
TL;DR: Molecular mechanisms of factors related to the EPR effect, the unique anatomy of tumor vessels, limitations and techniques to avoid such limitations, augmenting tumor drug delivery, and experimental and clinical findings are discussed.