Journal ArticleDOI
Osteochondral tissue engineering: Current strategies and challenges
TLDR
Novel factor strategies being developed, including single factor, multi-factor, or controlled factor release in a graded fashion, not only assist bone and cartilage regeneration, but also establish osteochondral interface formation.About:
This article is published in Biotechnology Advances.The article was published on 2013-09-01. It has received 326 citations till now.read more
Citations
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Journal ArticleDOI
Cell-laden hydrogels for osteochondral and cartilage tissue engineering
TL;DR: The fundamental problems encountered in this field are described and recent progress in designing cell-hydrogel hybrid constructs for promoting the reestablishment of osteochondral/cartilage tissues are reviewed.
Journal ArticleDOI
Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits
Yingying Du,Haoming Liu,Qin Yang,Shuai Wang,Jianglin Wang,Jun Ma,Insup Noh,Antonios G. Mikos,Shengmin Zhang +8 more
TL;DR: This study not only achieves osteochondral repair, but also suggests a promising strategy for the fabrication of bio-inspired multilayer scaffolds with well-designed architecture and gradient composition via SLS technique.
Journal ArticleDOI
Functionally graded materials for orthopedic applications – an update on design and manufacturing
TL;DR: Two fundamental topics are dedicated to, which are essential to benefit from the use of FGMs for orthopedic applications, namely the computational tools for materials design and geometry optimization and the manufacturing techniques currently available to produce FGM-based grafts.
Journal ArticleDOI
Current strategies in multiphasic scaffold design for osteochondral tissue engineering: A review.
TL;DR: The application of finite element analysis (FEA) in scaffold design and simulation of in vitro and in vivo cell growth outcomes and a summary of the existing challenges associated with the repair of osteochondral defects are brought up.
Journal ArticleDOI
Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits
Tanya J. Levingstone,Emmet M. Thompson,Amos Matsiko,Alexander Schepens,John P. Gleeson,Fergal J. O'Brien,Fergal J. O'Brien +6 more
TL;DR: A multi-layer collagen-based osteochondral defect repair scaffold designed to direct host-stem cell mediated tissue formation within each region shows the potential of this biomimetic multi-layered scaffold to support and guide the host reparative response in the treatment of oste mitochondral defects.
References
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Journal ArticleDOI
Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
TL;DR: Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.
Journal ArticleDOI
In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
TL;DR: A culture system that facilitates the chondrogenic differentiation of rabbit bone marrow-derived mesenchymal progenitor cells has been developed in this article, where cells obtained in bone marrow aspirates were first isolated by monolayer culture and then transferred into tubes and allowed to form three-dimensional aggregates in a chemically defined medium.
Journal ArticleDOI
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
Andrea Vortkamp,Kaechoong Lee,Beate Lanske,Gino V. Segre,Henry M. Kronenberg,Clifford J. Tabin +5 more
TL;DR: In vitro application of Hedgehog or P THrP protein to normal or PTHrP (−/−) limb explants demonstrated that PTHRP mediates the effects of Ihh through the formation of a negative feedback loop that modulates the rate of chondrocyte differentiation.
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A Randomized Trial of Arthroscopic Surgery for Osteoarthritis of the Knee
Alexandra Kirkley,Trevor B. Birmingham,Robert Litchfield,J. Robert Giffin,Kevin Willits,Cindy J. Wong,Brian G. Feagan,Allan Donner,Sharon Griffin,Janet E. Pope,Peter J. Fowler +10 more
TL;DR: In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthro scopic débridement were no better than those after a placebo procedure.
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Bone Tissue Engineering: Recent Advances and Challenges
TL;DR: The fundamentals of bone tissue engineering are discussed, highlighting the current state of this field, and the recent advances of biomaterial and cell-based research, as well as approaches used to enhance bone regeneration.