Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: a sociocultural perspective.
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TLDR
The prevalence of penicillin-nonsusceptible pneumococci is sharply divided between France and Germany, and the overarching importance of a sociocultural approach to preventing antibiotic resistance in the community is emphasized.Abstract:
The prevalence of penicillin-nonsusceptible pneumococci is sharply divided between France (43%) and Germany (7%). These differences may be explained on different levels: antibiotic- prescribing practices for respiratory tract infections; patient-demand factors and health-belief differences; social determinants, including differing child-care practices; and differences in regulatory practices. Understanding these determinants is crucial for the success of possible interventions. Finally, we emphasize the overarching importance of a sociocultural approach to preventing antibiotic resistance in the community.read more
Citations
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Keith S. Kaye,Paul G. Auwaerter,John A. Bosso,Nathan C. Dean,Gary V. Doern,Michael B. Kays,Jason M. Pogue,David J. Ritchie,Brian Wispelwey +8 more
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Low Dosage and Long Treatment Duration of β-Lactam: Risk Factors for Carriage of Penicillin-Resistant Streptococcus pneumoniae
Didier Guillemot,Claude Carbon,Beverley Balkau,Pierre Geslin,Hervé Lecoeur,Vauzelle-Kervroëdan F,Gilles Bouvenot,Eveline Eschwège +7 more
TL;DR: It is suggested that a low daily dose and a long duration of treatment with an oral beta-lactam contribute to the selective pressure in promoting pharyngeal carriage of penicillin-resistant S pneumoniae.