Journal ArticleDOI
Oxazolidinones: mechanisms of resistance and mobile genetic elements involved.
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TLDR
This review provides an overview on the diversity of the mobile genetic elements carrying oxazolidinone resistance genes in Gram-positive and Gram-negative bacteria.Abstract:
The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind to the peptidyl transferase centre of the bacterial ribosome inhibiting protein synthesis. Even if the majority of Gram-positive bacteria remain susceptible to oxazolidinones, resistant isolates have been reported worldwide. Apart from mutations, affecting mostly the 23S rDNA genes and selected ribosomal proteins, acquisition of resistance genes (cfr and cfr-like, optrA and poxtA), often associated with mobile genetic elements [such as non-conjugative and conjugative plasmids, transposons, integrative and conjugative elements (ICEs), prophages and translocatable units], plays a critical role in oxazolidinone resistance. In this review, we briefly summarize the current knowledge on oxazolidinone resistance mechanisms and provide an overview on the diversity of the mobile genetic elements carrying oxazolidinone resistance genes in Gram-positive and Gram-negative bacteria.read more
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Zoonotic and antibiotic-resistant Campylobacter: a view through the One Health lens
TL;DR: In this article , the emergence and transmission of antibiotic-resistant Campylobacter in the ecosystem are complex and multidirectional, and are affected by multiple factors, such as interspecies transmission and subsequent clonal expansion.
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Spreading of cfr-Carrying Plasmids among Staphylococci from Humans and Animals
Yuan Gao,Zheng Wang,Jiani Fu,Jiachang Cai,Tengfei Ma,Ning Xie,Run Fan,Weishuai Zhai,Andrea T. Feßler,Chengtao Sun,Congming Wu,Stefan Schwarz,Rong-gui Zhang,Yan Wang +13 more
TL;DR: In this article , the authors investigated the presence of the multidrug resistance gene cfr in 2,250 staphylococci of human clinical origin collected in Zhejiang, China, in 1998 to 2021.
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Antimicrobial agents in small animal dermatology for treating staphylococcal infections.
TL;DR: In this paper , the authors provide guidance on the treatment of methicillin-resistant Staphylococcus spp (MRSP) infections in dogs, especially in refractory cases.
Journal ArticleDOI
Co-location of the oxazolidinone resistance <i>poxtA2</i> and <i>cfr</i>(D) genes on a multiresistance plasmid from a porcine <i>Streptococcus dysgalactiae</i> subsp. <i>equisimilis</i>, Italy
TL;DR: Brenciani et al. as discussed by the authors investigated the co-location of the oxazolidinone resistance poxtA2 and cfr(D) genes on a multiresistance plasmid from a porcine Streptococcus dysgalactiae subsp. equisimilis.
Journal ArticleDOI
Nasal staphylococci community of healthy pigs and pig-farmers in Aragon (Spain). Predominance and within-host resistome diversity in MRSA-CC398 and MSSA-CC9 lineages
Idris Nasir Abdullahi,Carmen Lozano,Carmen Simón,Javier Latorre-Fernández,Myriam Zarazaga,Carmen Torres +5 more
TL;DR: In this paper , the diversity and carriage rate of nasal Staphylococcus spp., and within-host variability of antimicrobial resistance (AMR), virulence determinants, immune evasion cluster (IEC) types and genetic lineages of S. aureus isolates were investigated in four pig-farms (A-D) in Aragon (Spain).
References
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Journal ArticleDOI
Linezolid resistance in a clinical isolate of Staphylococcus aureus
Sotirios Tsiodras,Sotirios Tsiodras,Howard S. Gold,Howard S. Gold,George Sakoulas,George Sakoulas,George M. Eliopoulos,George M. Eliopoulos,Christine Wennersten,Lata Venkataraman,Robert C. Moellering,Robert C. Moellering,Mary Jane Ferraro +12 more
TL;DR: An MRSA isolate resistant to linezolid is characterised that was recovered from a patient treated with this agent for dialysis-associated peritonitis.
Journal ArticleDOI
The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics
TL;DR: The findings described in this study represent the first report of a gene conferring transferable resistance to pleuromutilins and oxazolidinones and the phenotype is named PhLOPSA for resistance to the following drug classes.
Journal ArticleDOI
Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid
Ronald D. Gonzales,Paul C. Schreckenberger,Mary Beth Graham,Swathi Kelkar,Karen DenBesten,John P. Quinn +5 more
TL;DR: Clinical details and antibiotic susceptibility from five patients treated with linezolid for VRE infections who had resistant organisms isolated during therapy are reported.
Journal ArticleDOI
Oxazolidinone structure-activity relationships leading to linezolid.
TL;DR: The work leading to the discovery of linezolid, the first clinically useful oxazolidinone antibacterial agent is described, which would exhibit a lack of cross-resistance with existing antimicrobial drugs.
Journal ArticleDOI
A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin
Yang Wang,Yuan Lv,Jiachang Cai,Stefan Schwarz,Lanqing Cui,Zhidong Hu,Rong Zhang,Jun Li,Qin Zhao,Tao He,Dacheng Wang,Zheng Wang,Yingbo Shen,Yun Li,Andrea T. Feßler,Congming Wu,Hao Yu,Xuming Deng,Xi Xia,Jianzhong Shen +19 more
TL;DR: The identification of a novel oxazolidinone resistance gene, optrA, and a first investigation of the extent to which this gene was present in E. faecalis and Enterococcus faecium are reported.