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Peptidomimetics via modifications of amino acids and peptide bonds
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TLDR
This work reviews recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone through structural features, utility and preparative methods.Abstract:
Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure–activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.read more
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Electrochemical strategies for C-H functionalization and C-N bond formation.
TL;DR: This review provides an overview on the use of anodic electrochemical methods for expediting the development of carbon-hydrogen functionalization and carbon-nitrogen bond formation strategies and aims to provide inspiration for future synthetic applications in the field of electrosynthesis.
Journal ArticleDOI
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Vangelis Agouridas,Ouafâa El Mahdi,Vincent Diemer,Marine Cargoët,Jean-Christophe Monbaliu,Oleg Melnyk +5 more
TL;DR: The most relevant properties of peptide thioesters, Cys peptides, and common solvents, reagents, additives, and catalysts used for these ligations are presented and the various thiol-based auxiliaries and thiol or selenol amino acid surrogates that have been developed so far are discussed.
Journal ArticleDOI
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides
Viktória Lázár,Viktória Lázár,Ana Martins,Réka Spohn,Lejla Daruka,Gábor Grézal,Gergely Fekete,Mónika Számel,Pramod Kumar Jangir,Bálint Kintses,Bálint Csörgő,Ákos Nyerges,Ádám Györkei,András Kincses,András Dér,Fruzsina R. Walter,Mária A. Deli,Edit Urbán,Zsófia Hegedűs,Gábor Olajos,Orsolya Méhi,Balázs Bálint,István Nagy,Tamás A. Martinek,Balázs Papp,Csaba Pál +25 more
TL;DR: The identification of antimicrobial peptide–antibiotic combinations that enhance antibiotic activity against multidrug-resistant bacteria and slow down de novo evolution of resistance are identified and guidelines for the development of efficient peptide-based therapies of antibiotic-resistant infections are provided.
Journal ArticleDOI
Late-Stage Peptide Diversification by Position-Selective C-H Activation.
TL;DR: Recent progress in organometallic C-H activation on peptides until June 2018 is summarized, including position- and chemoselective palladium-, ruthenium-, and manganese-catalyzed processes.
Journal ArticleDOI
Antimicrobial peptides under clinical investigation
Hye Been Koo,Jiwon Seo +1 more
TL;DR: This review lists the 36 antimicrobial peptides (AMPs) under clinical investigation and categorized several improvement strategies and highlighted directions for the future design of AMPs.
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