Journal ArticleDOI
Persistence of hepatitis B virus DNA in the liver after loss of HBsAg in chronic hepatitis B
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TLDR
It is indicated that loss of HBsAg is associated with marked improvements in clinical and serum biochemical features of chronic hepatitis B, yet mild degrees of hepatitis and low levels of viral DNA may persist in the liver.About:
This article is published in Hepatology.The article was published on 1993-12-01. It has received 167 citations till now. The article focuses on the topics: Hepatitis B virus DNA polymerase & HBsAg.read more
Citations
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Journal ArticleDOI
Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
Journal ArticleDOI
Chronic hepatitis B.
TL;DR: A large number of the patients diagnosed with hepatitis B in this study had no known history of cirrhosis, liver failure, or hepatocellular carcinoma.
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A meta‐analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma
TL;DR: The interaction between HBV and HCV infections was negative according to the multiplicative model, providing epidemiological evidence both of an independent effect and of interference between the 2 viruses in the carcinogenic process.
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Occult hepatitis B
TL;DR: Examination of occult hepatitis B in people co-infected with hepatitis C is examined, in whom Occult hepatitis B has been associated with advanced fibrosis and diminished response to interferon alpha.
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Reactivation of Hepatitis B
TL;DR: Routine prophylaxis is recommended for persons with HBsAg undergoing cancer chemotherapy or transplantation, but major questions remain, including which antiviral should be used and for how long.
References
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Journal ArticleDOI
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
Robert G. Knodell,Kamal G. Ishak,William C. Black,Thomas S. Chen,Robert M. Craig,Neil Kaplowitz,T Kiernan,Jerome Wollman +7 more
TL;DR: A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis that provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions.
Book
Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections
TL;DR: This revised edition includes chapters on monoclonal antibodies, electron microscopy, nucleic acid probes, papovaviruses, parvoviruses and human retroviruses.
Journal ArticleDOI
A Randomized, Controlled Trial of Interferon Alfa-2b Alone and after Prednisone Withdrawal for the Treatment of Chronic Hepatitis B
Robert P. Perrillo,Eugene R. Schiff,Gary L. Davis,Henry C. Bodenheimer,Karen L. Lindsay,John A. Payne,Jules L. Dienstag,Christopher B. O'Brien,Carlo H. Tamburro,Ira M. Jacobson,Richard E. Sampliner,David Feit,Jay H. Lefkowitch,Mary C. Kuhns,Carlton Meschievitz,Bharati Sanghvi,Janice K. Albrecht,Alexandra L. Gibas +17 more
TL;DR: Hepatitis B e antigen and hepatitis B viral DNA disappeared from serum significantly more often in the patients given prednisone plus interferon or 5 million units of interferons alone than in the untreated controls.
Journal ArticleDOI
Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study.
TL;DR: It is recommended that hepatitis B surface antigen-positive patients with malignancies receiving cytotoxic therapy be closely monitored, and male sex was the only factor that was associated with an increased risk of reactivation of hepatitis B virus replication.
Journal ArticleDOI
Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens.
TL;DR: Rec recombinant-DNA technology and gel electrophoresis suggest that integration of HBV-DNA into hepatocytes occurs during the course of persistent HBV infection and precedes development of gross neoplasm.