Perturbation of generation cycle of human leukemic blast cells by cytostatic therapy in vivo: effect of corticosteroids.
Peter Ernst,Sven-Aage Killmann +1 more
Reads0
Chats0
TLDR
It is concluded that prednisone has a general destructive effect both on actively proliferating and on quiescent leukemic lymphoblasts and some implications of this cytokinetic perturbation for therapeutic combination of corticosteroids with methotrexate and vincristine are discussed.About:
This article is published in Blood.The article was published on 1970-12-01 and is currently open access. It has received 78 citations till now. The article focuses on the topics: Vincristine & Bone marrow.read more
Citations
More filters
Journal ArticleDOI
Dexamethasone induces irreversible G1 arrest and death of a human lymphoid cell line.
TL;DR: Results show that dexamethasone arrests these leukemic T‐cell line cells in G1 and strongly suggest that DexamethAsone‐treated cells are killed upon entry into G1, suggesting a glucocorticoid receptor mediated mechanism for both phenomena.
Journal ArticleDOI
The effect of glucocorticosteroids on the proliferation and kinetics of promonocytes and monocytes of the bone marrow
J. Thompson,Ralph van Furth +1 more
TL;DR: It is concluded that a decreased production of monocytes in the bone marrow cannot account for the prolonged monocytopenia in the peripheral blood after hydrocortisone administration, however, hydroc Cortisone interferes with the release of newly formed monocytes from theBone marrow, resulting in a prolonged sojourn of these cells in this compartment.
Journal ArticleDOI
Synchronization and recruitment in acute leukemia
TL;DR: The results of these studies indicate that a greater therapeutic advantage can be achieved by a second cycle-dependent drug after synchronization than after the second drug alone.
Journal ArticleDOI
The cell cycle and its significance for cancer treatment.
Bridget T. Hill,Renato Baserga +1 more
TL;DR: The evidence presented above shows clearly that the application of certain principles of cell cycle kinetics can be of great benefit in the design of cancer treatments.
Journal Article
Inhibition of human lymphocyte stimulation by steroid hormones: Cytokinetic mechanisms
TL;DR: Late addition of steroid hormones to stimulated cultures reduced the per cent of cells in S phase, but did not revert previously transformed cycling lymphocytes to the G3 state, as shown by the decreased ([3H]thymidine incorporation/labelling index) ratio.
References
More filters
Journal ArticleDOI
Functional alterations in lymphoid tissue induced by adrenal cortical secretion
Journal ArticleDOI
Observations on the proliferation of human leucocytes cultured with phytohaemagglutinin.
TL;DR: A REMARKABLE finding reported recently by Nowell (1960) is the mitogenic effect of a bean extract in short-term cultures of normal human peripheral blood leucocytes, which directed particular attention to this aspect of cell metabolism in the culture system.
Journal Article
The Stathmokinetic Effect of Vincristine
TL;DR: There was an inverse correlation between the magnitude of the mitotic index increase and the generation time for the various tissues, and vincristine and vinblastine produced comparable marrow mitotic “arrest” in man, whereas leukopenia occurred regularly only with vin Blastine.