Journal ArticleDOI
PET versus SPECT: strengths, limitations and challenges
Arman Rahmim,Habib Zaidi +1 more
TLDR
This paper intends to balance the capabilities of the two major molecular imaging modalities used in nuclear medicine, namely positron emission tomography and single photon emission computed tomography (SPECT).Abstract:
The recent introduction of high-resolution molecular imaging technology is considered by many experts as a major breakthrough that will potentially lead to a revolutionary paradigm shift in health care and revolutionize clinical practice. This paper intends to balance the capabilities of the two major molecular imaging modalities used in nuclear medicine, namely positron emission tomography (PET) and single photon emission computed tomography (SPECT). The motivations are many-fold: (1) to gain a better understanding of the strengths and limitations of the two imaging modalities in the context of recent and ongoing developments in hardware and software design; (2) to emphasize that certain issues, historically and commonly thought as limitations of one technology, may now instead be viewed as challenges that can be addressed; (3) to point out that current state of the art PET and SPECT scanners can (greatly) benefit from improvements in innovative image reconstruction algorithms; and (4) to identify important areas of research in PET and SPECT imaging that will be instrumental to further improvements in the two modalities. Both technologies are poised to advance molecular imaging and have a direct impact on clinical and research practice to influence the future of molecular medicine.read more
Citations
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Journal ArticleDOI
New Developments in Liposomal Drug Delivery.
TL;DR: Bhushan S. Pattni,† Vladimir V. Chupin,‡ and Vladimir P. Torchilin study the role of phosphorous in the biosynthesis of Membrane Proteins and found that phosphorous binds to polypeptide A in a manner similar to that of polymethine.
Journal ArticleDOI
Gold Nanomaterials at Work in Biomedicine
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Nanomaterials for In Vivo Imaging
TL;DR: This work addresses the physicochemical makeup/design of nanomaterials through the lens of the physical properties that produce contrast signal for the cognate imaging modality-the authors stratify nanommaterials on the basis of their (i) magnetic, (ii) optical, (iii) acoustic, and/or nuclear properties.
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Advances in targeting the folate receptor in the treatment/imaging of cancers
TL;DR: The folate receptor is an important biomarker for many cancers, and its overexpression on tumours can be exploited for targeted therapy, diagnosis and imaging.
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Resolution modeling in PET imaging: Theory, practice, benefits, and pitfalls
TL;DR: The authors emphasize limitations encountered in the context of quantitative PET imaging, wherein increased intervoxel correlations due to resolution modeling can lead to significant loss of precision for small regions of interest, which can be a considerable pitfall depending on the task of interest.
References
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Journal ArticleDOI
Partial-Volume Effect in PET Tumor Imaging
TL;DR: What PVE is and its consequences in PET tumor imaging are described; the parameters on which PVE depends are reviewed; and actions that can be taken to reduce the errors attributable to PVE are described.
Journal ArticleDOI
A Method for Attenuation Correction in Radionuclide Computed Tomography
TL;DR: The method for attenuation correction in RCT is applied a simple, effective two-step procedure to the uncorrected image, and the filtered back-projection algorithm is used for its fast speed.
Journal Article
Performance of Philips Gemini TF PET/CT Scanner with Special Consideration for Its Time-of-Flight Imaging Capabilities
Suleman Surti,Austin Kuhn,Matthew E. Werner,Amy E. Perkins,Jeffrey A. Kolthammer,Joel S. Karp +5 more
TL;DR: The Gemini TF whole-body scanner represents the first commercially available fully 3-dimensional PET scanner that achieves time-of-flight capability as well as conventional imaging capabilities.
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Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution
Craig S. Levin,Edward J. Hoffman +1 more
TL;DR: A Monte Carlo simulation code is developed that models positron trajectories and calculates the distribution of the end point coordinates in water for the most common PET isotopes used: 18F, 13N, 11C and 15O to calculate what effect positron range has on the overall PET system spatial resolution, and how this influences the choice of PET system design parameters such as detector element size and system diameter.
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Fully 3-D PET reconstruction with system matrix derived from point source measurements
TL;DR: Experimental data were used to compare images reconstructed by the standard iterative reconstruction software and the one modeling the response function, and the results showed that the modeling of the responsefunction improves both spatial resolution and noise properties.