Journal ArticleDOI
Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects.
Deepa S. Mandlik,Ajay G. Namdeo +1 more
TLDR
This review has summarized the active phytoconstituents, pharmacologic activities (preclinical and clinical), mechanisms of action, potential beneficial applications, marketed formulations and safety and toxicity profile of W. somnifera.Abstract:
Withania somnifera, commonly known as “Ashwagandha” or “Indian ginseng” is an essential therapeutic plant of Indian subcontinent regions. It is regularly used, alone or in combination with other pl...read more
Citations
More filters
Journal ArticleDOI
Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management
Akash Saggam,Kirti Limgaokar,Swapnil P. Borse,Preeti Chavan-Gautam,Santosh Dixit,Girish Tillu,Bhushan Patwardhan +6 more
TL;DR: In this article, the authors presented a research synthesis of in silico, in vitro, in vivo, and clinical studies on Withania somnifera (L.) Dunal (WS) and discussed its potential for prophylaxis and management of COVID-19.
Journal ArticleDOI
Withania somnifera as a potential future drug molecule for COVID-19.
Vivek K. Kashyap,Vivek K. Kashyap,Anupam Dhasmana,Anupam Dhasmana,Murali M. Yallapu,Murali M. Yallapu,Subhash C. Chauhan,Subhash C. Chauhan,Meena Jaggi,Meena Jaggi +9 more
TL;DR: This research highlights the need to understand more fully the role of EMT in the development of central nervous system disease and its role in the immune response to chemotherapy.
Journal ArticleDOI
Phytotherapy for treatment of cytokine storm in COVID-19.
Leena Sapra,Asha Bhardwaj,Zaffar Azam,Deekhsha Madhry,Bhupendra Verma,Sumit Rathore,Rupesh K. Srivastava +6 more
TL;DR: Experimental validation of the effectiveness of these natural compounds to prevent or reduce the cytokine storm might be beneficial as an adjunct treatment of SARS-CoV-2.
Journal ArticleDOI
Withania somnifera (L.) Dunal: Phytochemistry, structure-activity relationship, and anticancer potential.
Devesh Tewari,Vikas Chander,A. Dhyani,Sanjeev Kumar Sahu,Pawan Gupta,Pooja Patni,Lindsay S. Kalick,Anupam Bishayee +7 more
TL;DR: An updated review on the anticancer potential and mechanisms of action of the major bioactive components of W. somnifera, including withanolides, withaferin A and withanone, is presented in this paper .
Journal ArticleDOI
Medicinal and therapeutic potential of withanolides from Withania somnifera against COVID-19
TL;DR: A review highlights the medicinal and therapeutic potential of withanolides against COVID-19 and identifies WFA as one of the most interesting naturally occurring bioactive compounds that possess potent anti-tumorigenic, antiinflammatory, pro-apoptotic, anti-angiogenic, and anti-invasive activities.
References
More filters
Journal Article
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
TL;DR: Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity, indicating this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects.
Journal ArticleDOI
A Textbook of Pharmacognosy
TL;DR: This text-book of pharmacognosy has grown from a laboratory manual intended for use in practical classes, and now comprises the requirements for the Chemist and Druggist Qualifying Examination of the Pharmaceutical Society of Great Britain.
Journal ArticleDOI
Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine.
TL;DR: Some of the problems in evaluation of adaptogens which have precluded their inclusion as clinically useful drugs are discussed.
Journal ArticleDOI
Steroidal lactones from Withania somnifera, an ancient plant for novel medicine.
TL;DR: An overview of the chemical structures of triterpenoid components and their biological activity is presented, focusing on two novel activities, tumor inhibition and antiangiogenic properties of withaferin A and the effects of withanolide A on Alzheimer's disease.
Related Papers (5)
Neuroprotective Potential of Withania somnifera (Ashwagandha) in Neurological Conditions
Rajat Sandhir,Abhilasha Sood +1 more