Book ChapterDOI
Neuroprotective Potential of Withania somnifera (Ashwagandha) in Neurological Conditions
Rajat Sandhir,Abhilasha Sood +1 more
- pp 373-387
Reads0
Chats0
TLDR
The article provides information on the mechanisms involved in neuroprotective ability of WS in preventing various neurodegenerative conditions.Abstract:
Withania somnifera, commonly known as Ashwagandha, is a herb used in the Indian Ayurvedic medical system for centuries for its health benefits in wide range of conditions. It has been documented to enhance the functions of the nervous system and improves cognition. Medicinal properties of Withania somnifera are primarily attributed to the presence of active constituents known as withanolides. The multimodal beneficial effects of WS and its constituents stem from its property to act as an anti-oxidant, anti-inflammatory, anti-cancer, hemopoietic and rejuvenating agent. WS has been shown to have beneficial role in many neurological conditions that include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, anxiety disorders, cerebral ischemia. However, the mechanisms involved in the beneficial effects of WS have not been well understood. The article provides information on the mechanisms involved in neuroprotective ability of WS in preventing various neurodegenerative conditions.read more
Citations
More filters
Journal ArticleDOI
Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects.
TL;DR: The purpose of this review is to outline the molecular mechanisms, signal transduction processes, and sites of action of some Ayurvedic medicinal plants and formulations used to slow down brain aging and enhance memory.
Journal ArticleDOI
Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives
Rajib Das,Abdur Rauf,Saima Akhter,Mohammad Nazmul Islam,Talha Bin Emran,Saikat Mitra,Ishaq N. Khan,Mohammad S. Mubarak +7 more
TL;DR: Withaferin A (WA) is derived from Withania somnifera (Ashwagandha) and Acnistus breviflorus (Gallinero), and it possesses inhibitory activities against developing a pathological marker of Alzheimer's diseases as discussed by the authors.
Journal ArticleDOI
Preparation and characterization of anticancer niosomal withaferin–A formulation for improved delivery to cancer cells: In vitro, in vivo, and in silico evaluation
Hamid Saeed Shah,Faisal Usman,Muhammad Ashfaq–Khan,Ruqaiya Khalil,Zaheer Ul-Haq,Aamir Mushtaq,Rabia Qaiser,Jamshed Iqbal +7 more
TL;DR: A significant in vivo antitumor effect of WA–niosome were observed as an archetype for cancer treatment and henceforth opened up more opportunities to maximize the potential of drugs that were obtained from natural sources.
Journal ArticleDOI
Nature's Derivative(s) as Alternative Anti-Alzheimer's Disease Treatments
Anuja Sharma,Yatender Kumar +1 more
TL;DR: The use of such alternative therapies borrowed from Ayurveda, traditional Chinese practices, meditation, and exercising for AD treatment will be a stepping-stone in preventing, treating, curing, or managing the disease.
Journal ArticleDOI
Elucidation of plasma protein binding, blood partitioning, permeability, CYP phenotyping and CYP inhibition studies of Withanone using validated UPLC method: An active constituent of neuroprotective herb Ashwagandha.
Sandeep Kumar Singh,Guru R. Valicherla,Anil Kumar Bikkasani,Srikanth H. Cheruvu,Zakir Hossain,Isha Taneja,Hafsa Ahmad,Kanumuri Siva Rama Raju,Neelam S. Sangwan,Shio K. Singh,Anil Kumar Dwivedi,Mohammad Wahajuddin,Jiaur R. Gayen,Jiaur R. Gayen +13 more
TL;DR: In this article, a reverse-phase ultra-performance liquid chromatographic method of WN was developed and validated in rat plasma for the first time, which was successfully applied to the in-vitro ADME investigation of WNs.
References
More filters
Journal ArticleDOI
Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection : a case control study
Daniel D Murray,Kazuo Suzuki,Matthew Law,Jonel Trebicka,Jacquie Neuhaus,Deborah Wentworth,Margaret Johnson,Michael J. Vjecha,Anthony D. Kelleher,Sean Emery,Bitten Aagaard,E. Aragon,J. Arnaiz,L. Borup,B Clotet,Ulrik Bak Dragsted,A. Fau,Daniela Gey,Jesper Grarup,U. Hengge,P. Herrero,Per O. Jansson,Birgitte Nybo Jensen,K. Jensen,H. Juncher,P. Lopez,Jens D Lundgren,C. Matthews,D. Mollerup,Mary T. Pearson,AN Phillips,S. Reilev,K. Tillmann,S. Varea,B. Angus,A. Babiker,B. Cordwell,J. Darbyshire,W. Dodds,S. Fleck,J. Horton,F. Hudson,Y. Moraes,F. Pacciarini,A. Palfreeman,Nicholas I. Paton,N. Smith,F. Van Hooff,J. Bebchuk,Gary Collins,Eileen Denning,Alain G. DuChene,Lisa Fosdick,M. Harrison,K. Herman-Lamin,Eric A. Krum,Gregg Larson,James D. Neaton,Ray Nelson,K. Quan,S. Quan,T. Schultz,G. Thompson,N. Wyman,Cate Carey,F. Chan,David A. Cooper,David Courtney-Rodgers,Fraser Drummond,Mary Ellen Harrod,S. Jacoby,L. Kearney,Enmoore Lin,Sarah Pett,R. Robson,N. Seneviratne,M. Stewart,E. Watts,Erin P. Finley,Fred M. Gordin,A. Sánchez,Barbara Standridge,W. Belloso,R. Davey,Daniel A. Duprez,J. Gatell,J. Hoy,Alan R. Lifson,Court Pederson,George Perez,Richard J. Price,Ronald J. Prineas,Frank S. Rhame,James H. Sampson,John Worley,J. Modlin,Valerie Beral,Richard E. Chaisson,T. Fleming,Christopher Hill,Kyungeun Kim,B. Murray,B. Pick,M. Seligmann,Ian Weller,K. Cahill,Lawrence Fox,M. Luzar,Ana Martinez,L. McNay,Jason Pierson,J. Tierney,Steven S. Vogel,V. Costas,Julie Eckstrand,Shawn K. Brown,L. Abusamra,E. Angel,S. Aquilia,J. Benetucci,V. Bittar,E. Bogdanowicz,Pedro Cahn,A. Casiro,J. Contarelli,J. Corral,L. Daciuk,Daniel David,W. Dobrzanski,A. Duran,J. Ebenrstejin,I. Ferrari,D. Fridman,V. Galache,G. Guaragna,S. Ivalo,Alejandro J. Krolewiecki,I. Lanusse,H. E. Laplume,M. Lasala,R. Lattes,J. Lazovski,Gustavo Lopardo,Marcelo H. Losso,L. Lourtau,S. Lupo,A. Maranzana,C. Marson,L. Massera,G. Moscatello,S. Olivia,I. Otegui,L. Palacios,A. Parlante,Horacio Salomón,Margarite Sanchez,C. Somenzini,C. Suarez,M. Tocci,J. Toibaro,C. Zala,S. Agrawal,P. Ambrose,C. Anderson,Jonathan P. Anderson,D. Baker,K. Beileiter,K. Blavius,Mark Bloch,MJ Boyle,D. Bradford,P. Britton,Pierre Antoine Brown,T. Busic,A. Cain,L. Carrall,S. Carson,I. Chenoweth,J. Chuah,F. Clark,J. Clemons,Kate Clezy,P. Cortissos,Nicola Cunningham,M. Curry,L. Daly,C. D'Arcy-Evans,R. Del Rosario,S. Dinning,P. Dobson,W. Donohue,Nicholas Doong,C. Downs,E. Edwards,Simon Edwards,C. Egan,W. Ferguson,Robert Finlayson,C. Forsdyke,L. Foy,T. Franic,A. Frater,M. French,D. Gleeson,Julian Gold,P. Habel,K. Haig,S. Hardy,R. Holland,J. Hudson,R. Hutchison,N. Hyland,Robert James,C. L. Johnston,Mark James Kelly,M. King,K. Kunkel,H. Lau,J. Leamy,D. Lester,J. Leung,A. Lohmeyer,K. Lowe,Karen MacRae,C. Magness,O. Martinez,H. Maruszak,Nicholas A. Medland,S. Miller,John M. Murray,P. Negus,R. Newman,M. Ngieng,C. Nowlan,J. Oddy,N. Orford,D. Orth,J. Patching,M. Plummer,S. Price,R. Primrose,I. Prone,H. Ree,C. Remington,Robyn Richardson,Stuart Robinson,G. Rogers,J. Roney,N Roth,Darren Russell,Stephanie Ryan,J. Sarangapany,T. Schmidt,Karen Schneider,C. Shields,C. Silberberg,D. Shaw,J. Skett,Davey M. Smith,T. Meng Soo,D. Sowden,A. Street,B. Kiem Tee,Jl Thomson,S. Topaz,R. Vale,C. Villella,Andrew Walker,A. Watson,N. Wendt,Lisa A. Williams,D. Youds,Alexander C Aichelburg,P. Cichon,B. Gemeinhart,Armin Rieger,B. Schmied,V. Touzeau-Romer,N. Vetter,R Colebunders,Nathan Clumeck,A. DeRoo,K. Kabeya,E. O'Doherty,S De Wit,C. De Salles Amorim,C. Basso,S. Flint,E. Kallas,G. Levi,D. Lewi,L. Pereira,M.L. Da Silva,T. Souza,A. Toscano,Jonathan B. Angel,M. Arsenault,M. Bast,B. Beckthold,P. Bouchard,I. Chabot,R. Clarke,Jeffrey I. Cohen,Pierre Côté,M E Ellis,C. Gagne,John Gill,M. Houde,B. Johnston,N. Jubinville,C. Kato,N. Lamoureux,J. Latendre-Paquette,A. Lindemulder,A. McNeil,N. McFarland,J. S. G. Montaner,C. Morrisseau,R. O'Neill,G. Page,A. Piche,B. Pongracz,H. Preziosi,L. Puri,Anita Rachlis,Edward D. Ralph,I. Raymond,Danielle Rouleau,Jean-Pierre Routy,Roger Sandre,T. Seddon,Stephen D. Shafran,C. Sikora,Fiona Smaill,D. Stromberg,Sylvie Trottier,Sharon Walmsley,K. Weiss,Kenneth M. Williams,Donald P. Zarowny,B. Baadegaard,Bengaard Andersen,K. Boedker,P. Collins,Gerstoft J,L. Jensen,Holger Jon Møller,P. Lehm Andersen,I. Loftheim,Lars Mathiesen,Henrik Nielsen,Niels Obel,Christian N. S. Pedersen,D. Petersen,L. Pors Jensen,F. Trunk Black,Aboulker Jp,Albertine Aouba,M. Bensalem,H. Berthé,C. Blanc,D. Bornarel,Olivier Bouchaud,François Boué,Elisabeth Bouvet,C. Brancon,S. Breaud,D. Brosseau,A. Brunet,C. Capitant,C. Ceppi,C. Chakvetadze,C. Cheneau,J. M. Chennebault,P. De Truchis,A. M. Delavalle,J.-F. Delfraissy,Pierre Dellamonica,C. Dumont,N. Edeb,G. Fabre,S. Ferrando,A. Foltzer,V. Foubert,J. A. Gastaut,J. Gerbe,P M Girard,Cécile Goujard,Bruno Hoen,P. Honoré,H. Hue,T. Hynh,C. Jung,S. Kahi,Christine Katlama,J. M. Lang,V. Le Baut,B. Lefebvre,N. Leturque,Yves Levy,J. Loison,G. Maddi,A. Maignan,C. Majerholc,C. De Boever,J. L. Meynard,Christian Michelet,C. Michon,M. Mole,E. Netzer,Gilles Pialoux,Isabelle Poizot-Martin,F Raffi,M. Ratajczak,I. Ravaux,Jacques Reynes,Dominique Salmon-Ceron,M. Sebire,A. Simon,L. Tegna,D. Tisne-Dessus,C. Tramoni,Jean-Paul Viard,M. Vidal,C. Viet-Peaucelle,Laurence Weiss,A. Zeng,D. Zucman,Alexander C. Adam,Keikawus Arastéh,Georg M. N. Behrens,F. Bergmann,Markus Bickel,D. Bittner,J. Bogner,Norbert H. Brockmeyer,N. Darrelmann,M. Deja,M. Doerler,Stefan Esser,Gerd Faetkenheuer,S. Fenske,S. Gajetzki,Frank D. Goebel,D. Gorriahn,E. Harrer,Thomas Harrer,H. Hartl,M. Hartmann,S. Heesch,W. Jakob,H. Jäger,Hartwig Klinker,G. Kremer,Christiane Ludwig,K. Mantzsch,Stefan Mauss,A. Meurer,A. Niedermeier,N. Pittack,A. Plettenberg,A. Potthoff,M. Probst,M. Rittweger,Juergen K. Rockstroh,B. Ross,J. Rotty,E. Rund,T. Ruzicka,Rt Schmidt,Guenther Schmutz,E. Schnaitmann,D. Schuster,T. Sehr,B. Spaeth,S Staszewski,Hans-Jürgen Stellbrink,Christoph Stephan,T. Stockey,Albrecht Stoehr,A. Trein,T. Vaeth,Martin Vogel,Jan Christian Wasmuth,C. Wengenroth,R. Winzer,Eva Wolf,Fiona Mulcahy,Dl Reidy,Y. Cohen,G. Drora,I. Eliezer,O. Godo,E. Kedem,E. Magen,M. Mamorsky,Shimon Pollack,Z. Sthoeger,H. Vered,Israel Yust,F. Aiuti,M. Bechi,A. Bergamasco,Davide Bertelli,Raimondo Bruno,Luca Butini,M. Cagliuso,G. Carosi,S. Casari,V. Chrysoula,G. Cologni,V. Conti,A. Costantini,A. Corpolongo,Gianpiero D’Offizi,F. Gaiottino,M. Di Pietro,Roberto Esposito,Gaetano Filice,M. Francesco,Erika Gianelli,C. Graziella,L. Magenta,F. Martellotta,Renato Maserati,Francesco Mazzotta,Giuseppe Murdaca,G. Nardini,Silvia Nozza,Francesco Puppo,Manuela Pogliaghi,Diego Ripamonti,C. Ronchetti,Stefano Rusconi,V. Rusconi,P. Sacchi,N. Silvia,Fredy Suter,Giuseppe Tambussi,Alessia Uglietti,M. Vechi,Barbara Vergani,Francesca Vichi,Paola Vitiello,Aikichi Iwamoto,Y. Kikuchi,N. Miyazaki,M. Mori,T. Nakamura,Takashi Odawara,Shinichi Oka,T. Shirasaka,M. Tabata,M. Takano,C. Ueta,D. Watanabe,Y. Yamamoto,I. Erradey,H. Himmich,K. Marhoum El Filali,W. Blok,R. Van Boxtel,K. Brinkman H. Doevelaar,A. Van Eeden,M. Grijsen,M. Groot,J. Juttmann,M. Kuipers,S. Ligthart,P. Van Der Meulen,J. M. A. Lange,N. Langebeek,Peter Reiss,C. Richter,M. Schoemaker,L. Schrijnders-Gudde,E. Septer-Bijleveld,Herman G. Sprenger,J. Vermeulen,R. W. ten Kate,B. Van De Ven,Johan N. Bruun,D. Kvale,A. Maeland,E. Bakowska,M. Beniowski,Anna Boroń-Kaczmarska,J Gasiorowski,A Horban,M. Inglot,Brygida Knysz,E. Mularska,Miłosz Parczewski,M. Pynka,W. Rymer,Aleksandra Szymczak,M. Aldir,F Antunes,C. Baptista,J. Da Conceicao Vera,Manuela Doroana,Kamal Mansinho,C. Raquel A. Dos Santos,Emília Valadas,I. Vaz Pinto,E. Chia,E. Foo,F. Karim,P. L. Lim,A. Panchalingam,A. Quek,R. Alcázar-Caballero,Jose R. Arribas,J. Arrizabalaga,X. De Barron,Francisco J. Blanco,Emilio Bouza,Isabel Bravo,S. Calvo,L. Carbonero,I. Carpena,M. Castro,L. Cortes,M. Del Toro,Pere Domingo,M. Elias,J. Espinosa,Vicente Estrada,Eduardo Fernández-Cruz,P. Fernández,H. Freud,M. Fuster,A. Garcia,G. Garcia,R. Garrido,P. Gijón,Juan González-García,Ignacio Gil,A. Gonzalez,Juan González-Lahoz,P. López Grosso,M. Gutiérrez,E. Guzmán,José Antonio Iribarren,Maribel Jiménez,A. Jou,J. Juega,J. C. López,F. Lozano,Luz Martín-Carbonero,R. Mata,G. Mateo,A. Menasalvas,C. Mirelles,J. De Miguel Prieto,Matthieu Montes,A. Moreno,J. Moreno,Victoria Moreno,R. Muñoz,Antonio Ocampo,Enrique Ortega,L. Ortiz,B. Padilla,A. Parras,A. Paster,José Pedreira,José Peña,R. Perea,B. Portas,Jordi Puig,Federico Pulido,M. Rebollar,J. De Rivera,V. Roca,F. Rodríguez-Arrondo,Rafael M. Rubio,Jesús Santos,Jesús Sanz,G. Sebastian,M. Segovia,Vincent Soriano,L. Tamargo,Pompeyo Viciana,M. Von Wichmann,G. Bratt,A. Hollander,P. Olov Pehrson,I. Petz,Eric Sandström,Anders Sönnerborg,Enos Bernasconi,V. Gurtner,U. Ampunpong,C. Auchieng,Chureeratana Bowonwatanuwong,P. Chanchai,Ploenchan Chetchotisakd,T. Chuenyan,Chris Duncombe,M. Horsakulthai,Pacharee Kantipong,K. Laohajinda,Praphan Phanuphak,V. Pongsurachet,S. Pradapmook,K. Ruxruntham,S. Seekaew,A. Sonjai,Surapol Suwanagool,Wichai Techasathit,Sasiwimol Ubolyam,J. Wankoon,I. Alexander,D. Dockrell,P. Easterbrook,B. Edwards,E. Evans,M Fisher,Ray Fox,Brian Gazzard,G. Gilleran,J. Hand,L. Heald,C. Higgs,S. Jebakumar,I. Jendrulek,S. Johnson,G. Kinghorn,K. Kuldanek,Clifford Leen,R. Maw,S. McKernan,L. McLean,Sheila Morris,Michael E. P. Murphy,S. O'Farrell,E. Ong,Barry Peters,C. Stroud,M. Wansbrough-Jones,J Weber,David P. White,Ian Williams,Martin Wiselka,T. Yee,Sally Adams,D. Allegra,L. Andrews,B. Aneja,Gregory M. Anstead,Roberto C. Arduino,R. Artz,J. Bailowitz,S. Banks,J. Baxter,J. Baum,Debra Benator,Deborah Black,D. Boh,T. Bonam,M. Brito,J. Brockelman,V. Bruzzese,A. Burnside,V. Cafaro,K. Casey,L. Cason,G. Childress,C. Clark,D. Clifford,M. Climo,David L. Cohn,P. Couey,H. Cuervo,Steven G. Deeks,M. Dennis,M. Diaz-Linares,D. Dickerson,Mercedes Díez,J. Di Puppo,P. Dodson,D. Dupre,Richard Elion,K. Elliott,Wafaa El-Sadr,M. Estes,J. Fabre,M. Farrough,Jason Flamm,Stephen E. Follansbee,C. Foster,C. Frank,J. Franz,G. Frechette,G. Freidland,J. Frische,L. Fuentes,C. Funk,Christian H. Geisler,K. Genther,Michelle L. Giles,M. Goetz,María del Mar González,C. Graeber,F. Graziano,D. Grice,B. Hahn,C. Hamilton,S. Hassler,A. Henson,S. Hopper,Mina John,Leigh F. Johnson,Randall C. Johnson,Rachael M. Jones,JE Kahn,Nancy G. Klimas,M. Kolber,S. Koletar,Ann M. Labriola,R. Larsen,F. Lasseter,Michael M. Lederman,T. Ling,T. Lusch,Rodger D. MacArthur,C. Machado,L. Makohon,J. Mandelke,Sharon B. Mannheimer,N. Markowitz,María Luz Pindado Martínez,N. Martinez,M. Mass,Henry Masur,D. McGregor,D. McIntyre,J. McKee,D. McMullen,M. Mettinger,S. Middleton,J. Mieras,Donna Mildvan,P J Miller,T. Miller,V. Mitchell,Ronald T. Mitsuyasu,A. Moanna,C. Mogridge,F. Moran,Robert L. Murphy,David M. Mushatt,R. Nahass,Daniel E. Nixon,S. O'Brien,J. Ojeda,P. Okhuysen,M. Olson,J. Osterberger,W. Owen,S. Pablovich,S. Patel,Gerald Pierone,R. Poblete,A. Potter,E. Preston,Claire Rappoport,N. Regevik,M. Reyelt,L. Riney,Maria C. Rodriguez-Barradas,Juan Carlos Rodríguez,R. Roland,C. Rosmarin-DeStefano,W. Rossen,J. Rouff,Michael S. Saag,S. Santiago,J. Sarria,Stefan Wirtz,U. Schmidt,C. Scott,A. Sheridan,A. Shin,S. Shrader,Georges Simon,D. Slowinski,Kirsty S Smith,J. Spotkov,C. Sprague,D. States,C. Suh,John S. Sullivan,K. Summers,B. Sweeton,V. Tan,T. Tanner,E. Tedaldi,Zelalem Temesgen,Daniel Thomas,Melanie Thompson,C. Tobin,N. Toro,William J. Towner,K. Upton,J. Uy,S. Valenti,C. Van Der Horst,J. Vita,Jocelyn Voell,John Walker,T. Walton,K. Wason,Victoria Watson,A. Wellons,J. Weise,Martha V. White,Timothy J. Whitman,B. Williams,Nana Aba Williams,J. Windham,M. Witt,K. Workowski,Glenn Wortmann,Thomas K. Wright,C. Zelasky,B. Zwickl,D. Dietz,C. Chesson,M. Vjecha,Barry Schmetter,L. Grue,M. Willoughby,A. Demers,U. B. Dragsted,K. B. Jensen,P. O. Jansson,B. G. Jensen,Thomas Benfield,Janet Darbyshire,G. Babiker,S. L. Fleck,Yolanda Collaco-Moraes,L. Wyzydrag,F. M. Drummond,S. A. Connor,Claudette S. Satchell,S. Gunn,M. A. Delfino,Kate Merlin,C. McGinley,James D. Neaton,Glenn E. Bartsch,M. George,Birgit Grund,Carlton Hogan,Cari L. Miller,Mollie P. Roediger,Lisa M. Thackeray,Colin Campbell,C. Lahart,David C. Perlman,M. Rein,Rebecca DerSimonian,B. A. Brody,E. S. Daar,N. N. Dubler,T. R. Fleming,D. J. Freeman,J. P. Kahn,Keewan Kim,G. Medoff,J. F. Modlin,R. Moellering,B. E. Murray,Merlin L. Robb,D. O. Scharfstein,J. Sugarman,A. Tsiatis,C. Tuazon,L. Zoloth,Karin L. Klingman,S. Lehrman,W. H. Belloso,M. H. Losso,J. A. Benetucci,E. P. Bogdanowicz,P. Cahn,Arnaldo Casiro,Isabel Cassetti,J. M. Contarelli,J. A. Corral,A. Crinejo,D. O. David,M. T. Ishida,H. E. Laplume,M. B. Lasala,S. H. Lupo,F. Masciottra,M. Michaan,L. Ruggieri,E. Salazar,Jennifer F Hoy,Gary David Rogers,A. M. Allworth,J Anderson,Jude Armishaw,K. Barnes,Andrew Carr,A. Chiam,J. C.P. Chuah,M. C. Curry,Robyn Dever,W. A. Donohue,Nicholas Doong,Dominic E. Dwyer,J. Dyer,B. Eu,V. W. Ferguson,Martyn A. French,Roger Garsia,Jeff Hudson,S. Jeganathan,Pamela Konecny,C. L. McCormack,Marilyn McMurchie,Richard James Moore,M. B. Moussa,M. Piper,Timothy D. Read,J. J. Roney,D. R. Shaw,J. Silvers,David Smith,Alan C Street,R. J. Vale,N. A. Wendt,H. Wood,D. W. Youds,J. Zillman,V. Tozeau,S. DeWit,A. De Roo,P. Leonard,Lut Lynen,M Moutschen,L. C. Pereira,T. N.L. Souza,Martin T. Schechter,Roberto Zajdenverg,M. M.T.B. Almeida,F. Araujo,F. Bahia,Carlos Brites,M. M. Caseiro,J. Casseb,A. Etzel,G. G. Falco,E. C.J. Filho,S. R. Flint,R. Gonzales,José Valdez Madruga,L. N. Passos,T. Reuter,L. C. Sidi,A. L.C. Toscano,E. Cherban,Brian Conway,C. Dufour,A. Foster,David Haase,H. Haldane,Marina B. Klein,B. Lessard,Alain Martel,C. Martel,E. Paradis,Walter F. Schlech,Sigrún Alba Jóhannesdóttir Schmidt,B. Thompson,Sylvie Vézina,M. J.Wolff Reyes,R. Northland,Lars Østergaard,L. Hergens,I. R. Loftheim,M. Raukas,Kai Zilmer,J. Justinen,Matti Ristola,R. Landman,S. Abel,Sophie Abgrall,K. Amat,L. Auperin,R. Barruet,A. Benalycherif,N. Benammar,M. Bentata,J. M. Besnier,M. Blanc,André Cabié,P. Chavannet,Sylvie Dargere,X. De La Tribonniere,T. Debord,N. Decaux,J. Delgado,Michel Dupon,J. Durant,V. Frixon-Marin,C. Genet,Laurence Gérard,J. Gilquin,V. Jeantils,H. Kouadio,P. Leclercq,Jean-Daniel Lelièvre,C. P. Michon,P. Nau,J. Pacanowski,C. Piketty,Dominique Salmon,J. L. Schmit,M. A. Serini,S. Tassi,F. Touam,Renaud Verdon,Pierre Weinbreck,Yazdan Yazdanpanah,Patrick Yeni,Gerd Fätkenheuer,S. Bitsch,Johannes R. Bogner,Frank-D. Goebel,Clara Lehmann,T. Lennemann,Jan-Christian Wasmuth,K. Wiedemeyer,Angelos Hatzakis,Giota Touloumi,A. Antoniadou,G. L. Daikos,A. Dimitrakaki,P. Gargalianos-Kakolyris,M. Giannaris,Anastasia Karafoulidou,A. Katsambas,Olga Katsarou,A. N. Kontos,T. Kordossis,Marios M.K. Lazanas,P. Panagopoulos,George Panos,Vassilios Paparizos,V. Papastamopoulos,G. Petrikkos,H. Sambatakou,Athanassios Skoutelis,N. Tsogas,G. Xylomenos,Colm Bergin,B. Mooka,M. G. Mamorksy,N. Agmon-Levin,R. Karplus,S. Maayan,Eyal Shahar,Dane Turner,C. Abeli,A. Biglino,Stefano Bonora,M. De Gioanni,G. Di Perri,Maria Montroni,Tiziana Quirino,E. Raise,M. Honda,M. Ishisaka,S. Caplinskas,V. Uzdaviniene,J-C Schmit,Thérèse Staub,Graham Mills,T. Blackmore,Jeffrey Masters,J. Morgan,A. Pithie,J. Brunn,V. Ormassen,A. La Rosa,O. Guerra,M. Espichan,L. Gutierrez,F. Mendo,R. Salazar,B. Knytz,J. Kwiatkowski,R. S. Castro,A. Horta,A. C. Miranda,I. V. Pinto,J Vera,A Rakhmanova,E. Vinogradova,A. Yakovlev,Natalia V. Zakharova,Robin Wood,C. Orrel,J.A. Arnaiz,R. Carrillo,David Dalmau,Q. Jordano,H. Knobel,M. Larrousse,J. S. Moreno,E. Oretaga,J. N. Pena,Bernard Hirschel,R. Spycher,Manuel Battegay,S. Bottone,Matthias Cavassini,A. Christen,Hansjakob Furrer,Angèle Gayet-Ageron,Daniel Genné,S. Hochstrasser,C. Moens,N. Müller,Reto Nüesch,K Ruxrungtham,W. Pumpradit,S. Dangthongdee,Sasisopin Kiertiburanakul,Virat Klinbuayaem,Piroon Mootsikapun,S. Nonenoy,B. Piyavong,Wisit Prasithsirikul,Phitsanu Raksakulkarn,Brian Gazzard,Jonathan Ainsworth,B. J. Angus,Tristan Barber,M. G. Brook,C. D. Care,David R. Chadwick,M. Chikohora,Duncan Churchill,D. Cornforth,D. H. Dockrell,Philippa Easterbrook,Penny Fox,P. A. Gomez,Mark Gompels,G. M. Harris,Stephen J. Herman,Akil Jackson,S. P.R. Jebakumar,G. R. Kinghorn,K. A. Kuldanek,N. Larbalestier,M. Lumsden,T. Maher,J. Mantell,L. Muromba,Chloe Orkin,S. Peters,Tim E. A. Peto,Simon Portsmouth,S. Rajamanoharan,Ronan,Achim Schwenk,M. A. Slinn,C. J. Stroud,R. C. Thomas,M. H. Wansbrough-Jones,H. J. Whiles,David White,E. Williams,G. Williams,M Youle,Donald I. Abrams,E. A. Acosta,A. Adamski,D. Antoniskis,D. R. Aragon,Ben J. Barnett,C. Baroni,M. Barron,John D. Baxter,D. Beers,M. Beilke,Bemenderfer,A. Bernard,Camille Besch,M. T. Bessesen,J. T. Bethel,S. Blue,J. D. Blum,S. Boarden,Robert K. Bolan,J. B. Borgman,Indira Brar,B. K. Braxton,U. F. Bredeek,R. Brennan,D. E. Britt,D. Bulgin-Coleman,E. Bullock,B. Campbell,S. Caras,J. Carroll,K. K. Casey,F. Chiang,R. B. Cindrich,Cal Cohen,J. Coley,D. V. Condoluci,R. Contreras,J. Corser,J. Cozzolino,Lawrence R. Crane,L. Daley,D. Dandridge,V. D'Antuono,J. G. Darcourt Rizo Patron,J. A. DeHovitz,Edwin DeJesus,J. DesJardin,C. Dietrich,A. Dolce,D. Erickson,L. L. Faber,J. Falbo,M. J. Farrough,Charles Farthing,P. Ferrell-Gonzalez,H. Flynn,M. Frank,K. F. Freeman,N. French,Gerald Friedland,N. Fujita,L. Gahagan,I. Gilson,Matthew Bidwell Goetz,E. Goodwin,C. K. Guity,P. Gulick,E. R. Gunderson,C. M. Hale,K. Hannah,H. Henderson,K. Hennessey,W. K. Henry,T. Higgins,Sally Hodder,H. W. Horowitz,M. Howe-Pittman,J. Hubbard,R. Hudson,H. Hunter,C. Hutelmyer,M. T. Insignares,Lois A. Jackson,L. Jenny,D. L. Johnson,G. Johnson,Jeffrey A. Johnson,J. Kaatz,J. Kaczmarski,S. Kagan,C. Kantor,T. Kempner,K. Kieckhaus,N. Kimmel,B. M. Klaus,J. R. Koeppe,Janak Koirala,J. Kopka,J. R. Kostman,Michael J. Kozal,Ashok Kumar,Harry Lampiris,C. Lamprecht,K. M. Lattanzi,J. Lee,J. Leggett,C. Long,A. Loquere,K. Loveless,C. Lucasti,R. Luskin-Hawk,M. MacVeigh,L. H. Makohon,Norman Markowitz,C. Marks,Claudia Martorell,E. McFeaters,B. McGee,D. M. McIntyre,E. McManus,L. G. Melecio,D. Melton,S. Mercado,E. Merrifield,J. A. Mieras,M. Mogyoros,F. M. Moran,Kellie E. Murphy,S. Mutic,I. Nadeem,J. P. Nadler,A. Ognjan,Mary O'Hearn,K. O'Keefe,P. C. Okhuysen,E. Oldfield,D. Olson,R. Orenstein,Roberto Ortiz,F. Parpart,V. Pastore-Lange,S. Paul,A. Pavlatos,D. D. Pearce,R. Pelz,S. Peterson,D. Pitrak,S. L. Powers,H. C. Pujet,J. W. Raaum,J. Ravishankar,J. Reeder,N. A. Reilly,C. Reyelt,J. Riddell,David Rimland,M. L. Robinson,Allen E. Rodriguez,V. Rodriguez Derouen,C. Rosmarin,W. L. Rossen,J. R. Rouff,M. Sands,C. Savini,Shannon Schrader,M. M. Schulte,R. Scott,H. Seedhom,Michael Sension,A. ShebleHall,Jonathan Shuter,Leonard N. Slater,R. Slotten,Miranda Zoe Denham Smith,S. Snap,D. M. States,G. Stringer,K. K. Summers,K. Swanson,I. B. Sweeton,S. Szabo,Ellen Tedaldi,Edward E. Telzak,Melanie A. Thompson,Sandra C. Thompson,C. Ting Hong Bong,A. Vaccaro,L. M. Vasco,I. Vecino,G. K. Verlinghieri,Fehmida Visnegarwala,H. Wade,Stephen E. Weis,J. A. Weise,S. Weissman,M. Wilkin,J. H. Witter,L. Wojtusic,T. J. Wright,V. Yeh,B. Young,C. Zeana,J. Zeh,E. Savio,M. Vacarezza +1489 more
TL;DR: No associations with mortality were found with any circulating miRNAs studied and these results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.
Journal ArticleDOI
Neuropathological Alterations in Alzheimer Disease
TL;DR: Postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies, and the development of diagnostic criteria that are now used worldwide, and these cross-sectional neuropathological data have been largely validated by longitudinal in vivo studies using modern imaging biomarkers such as amyloids PET and volumetric MRI.
Journal ArticleDOI
Epileptic seizures and epilepsy : Definitions proposed by the international league against epilepsy (ILAE) and the international bureau for epilepsy (IBE)
Ettore Beghi,Anne T. Berg,Arturo Carpio,Lars Forsgren,Dale C. Hesdorffer,W. Allen Hauser,Kristina Malmgren,Shlomo Shinnar,Nancy R. Temkin,David J. Thurman,Torbjörn Tomson +10 more
TL;DR: The International League Against Epilepsy (ILAE) and the International Bureau for Epilepsia (IBE) have come to consensus definitions for the terms epileptic seizure and epilepsy.
Journal ArticleDOI
Control of yellow and purple nutsedge in elevated CO2 environments with glyphosate and halosulfuron.
TL;DR: It is likely that predicted future CO2 levels will have little impact on the efficacy of single applications of halosulfuron or glyphosate for control of purple and yellow nutsedge at the growth stages described here, although scenarios demanding more persistent control efforts remain a question.
Journal ArticleDOI
Oxidative stress in Parkinson's disease
TL;DR: Oxidative stress contributes to the cascade leading to dopamine cell degeneration in Parkinson's disease (PD), but oxidative stress is intimately linked to other components of the degenerative process, such as mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity and inflammation.