Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling.
Anmol Sharma,Heena Khan,Thakur Gurjeet Singh,Amarjot Kaur Grewal,Agnieszka Najda,Małgorzata Kawecka-Radomska,Mohamed Kamel,Ahmed E. Altyar,Mohamed M. del-Daim +8 more
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TLDR
A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was carried out to understand the nature of the extensive work done on modulation of ubiquitin-proteasome pathways in oncogenic signaling as discussed by the authors.Abstract:
The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is widely known for its role in degrading abnormal protein substrates and maintaining physiological body functions via ubiquitinating enzymes (E1, E2, E3) and the proteasome. Therefore, aberrant expression in these enzymes results in an altered biological process, including transduction signaling for cell death and survival, resulting in cancer. In this review, an overview of profuse enzymes involved as a pro-oncogenic or progressive growth factor in tumors with their downstream signaling pathways has been discussed. A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was carried out to understand the nature of the extensive work done on modulation of ubiquitin-proteasome pathways in oncogenic signaling. Various in vitro, in vivo studies demonstrating the involvement of ubiquitin-proteasome systems in varied types of cancers and the downstream signaling pathways involved are also discussed in the current review. Several inhibitors of E1, E2, E3, deubiquitinase enzymes and proteasome have been applied for treating cancer. Some of these drugs have exhibited successful outcomes in in vivo studies on different cancer types, so clinical trials are going on for these inhibitors. This review mainly focuses on certain ubiquitin-proteasome enzymes involved in developing cancers and certain enzymes that can be targeted to treat cancer.read more
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Weiwei Zhang,Yuan Zhuang,Yiran Zhang,Xiaoran Yang,Hong Zhang,Guifen Wang,Wanqi Yin,Ruifeng Wang,Zhiling Zhang,Wei Xiao,Wei Xiao +10 more
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Sun-Il Yun,Hye Kyung Hong,So-Young Yeo,Seok-Hyung Kim,Yong Beom Cho,Kyeong Kyu Kim,Kyeong Kyu Kim +6 more
TL;DR: It is found that ubiquitin-specific protease 21 (USP21) increasesFra-1 stability by deubiquitinating Fra-1 and enhances the expression of Fra-3 target genes in colon cancer cells and is considered an attractive therapeutic target in mCRC with high Fra- 1 expression.
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Thomas Hermanns,Kay Hofmann +1 more
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