Journal ArticleDOI
Phase III, Open-Label, Randomized Study Comparing Concurrent Gemcitabine Plus Cisplatin and Radiation Followed by Adjuvant Gemcitabine and Cisplatin Versus Concurrent Cisplatin and Radiation in Patients With Stage IIB to IVA Carcinoma of the Cervix
Alfonso Dueñas-González,J. J. Zarba,Firuza Patel,Juan C. Alcedo,Semir Beslija,Luis Casanova,Pittayapoom Pattaranutaporn,Shahid Hameed,Julie M. Blair,Helen Barraclough,Mauro Orlando +10 more
TLDR
Gem citabine plus cisplatin chemoradiotherapy followed by BCT and adjuvant gemcitabine/cisplatin chemotherapy improved survival outcomes with increased but clinically manageable toxicity when compared with standard treatment.Abstract:
Purpose To determine whether addition of gemcitabine to concurrent cisplatin chemoradiotherapy and as adjuvant chemotherapy with cisplatin improves progression-free survival (PFS) at 3 years compared with current standard of care in locally advanced cervical cancer. Patients and Methods Eligible chemotherapy- and radiotherapy-naive patients with stage IIB to IVA disease and Karnofsky performance score ≥ 70 were randomly assigned to arm A (cisplatin 40 mg/m2 and gemcitabine 125 mg/m2 weekly for 6 weeks with concurrent external-beam radiotherapy [XRT] 50.4 Gy in 28 fractions, followed by brachytherapy [BCT] 30 to 35 Gy in 96 hours, and then two adjuvant 21-day cycles of cisplatin, 50 mg/m2 on day 1, plus gemcitabine, 1,000 mg/m2 on days 1 and 8) or to arm B (cisplatin and concurrent XRT followed by BCT only; dosing same as for arm A). Results Between May 2002 and March 2004, 515 patients were enrolled (arm A, n = 259; arm B, n = 256). PFS at 3 years was significantly improved in arm A versus arm B (74.4% v ...read more
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Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Nicoletta Colombo,Nicoletta Colombo,Silvestro Carinelli,Alessandro Colombo,C. Marini,D. Rollo,Cristiana Sessa +6 more
Journal ArticleDOI
Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer.
Richard Pötter,Petra Georg,Johannes Dimopoulos,Magdalena Grimm,Daniel Berger,Nicole Nesvacil,Dietmar Georg,Maximilian Schmid,Alexander Reinthaller,Alina Sturdza,Christian Kirisits +10 more
TL;DR: 3D conformal radiotherapy ± chemotherapy plus image (MRI) guided adaptive intracavitary brachytherapy including needle insertion in advanced disease results in local control rates of 95–100% at 3 years in limited/favourable (IB/IIB) and 85–90% in large/poor response (IIB/III/IV) cervix cancer patients associated with a moderate rate of treatment related morbidity.
Journal ArticleDOI
Cancer of the cervix uteri
TL;DR: This chapter discusses the management of cervical cancer based on the stage of disease, including attention to palliation and quality of life issues.
Journal ArticleDOI
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial
Sudeep Gupta,Amita Maheshwari,Pallavi Parab,Umesh Mahantshetty,Rohini Hawaldar,Supriya Chopra,Rajendra Kerkar,Hemant B. Tongaonkar,Jaya Ghosh,Seema Gulia,Neha Kumar,T. Surappa Shylasree,Renuka Gawade,Yogesh Kembhavi,Madhuri Gaikar,Santosh Menon,Meenakshi Thakur,Shyam K. Shrivastava,Rajendra A. Badwe +18 more
TL;DR: Cisplatin-based concomitant chemoradiation resulted in superior DFS compared with neoadjuvant chemotherapy followed by radical surgery in locally advanced cervical cancer.
Journal ArticleDOI
Cancer of the cervix uteri
TL;DR: The cervix is the lower aspect of the uterus and projects through the superior-anterior vaginal wall, and communicates with the vagina through the endocervical canal, which terminates in the external os located at the top of the vagina.
References
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TL;DR: The addition of chemotherapy with fluorouracil and cisplatin to treatment with external-beam and intracavitary radiation significantly improved survival among women with locally advanced cervical cancer.