Journal ArticleDOI
Philadelphia-Chromosome-Positive and -Negative Chronic Myelocytic Leukemia
TLDR
Chromosomal studies were performed on 61 adult patients with "typical chronic myelocytic leukemia" and the Philadelphia (Ph1) chromosome was found in 43 patients, with equal sex distribution a year after diagnosis.Abstract:
Chromosomal studies were performed on 61 adult patients with "typical chronic myelocytic leukemia. The Philadelphia (Ph1) chromosome was found in 43 patients, with equal sex distribution a...read more
Citations
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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
TL;DR: An unsuspected abnormality in all cells from the nine patients with chronic myelogenous leukaemia has been detected with quinacrine fluorescence and various Giemsa staining techniques, suggesting that there may be a hitherto undetected translocation between the long arm of 22 and thelong arm of 9, producing the 9q+ chromosome.
Journal ArticleDOI
The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias
TL;DR: A novel approach is proposed to evaluate the role of “cellular oncogenes ” in the pathogenesis of leukaemia by exploiting their role in the “translation” of DNA to RNA.
Journal ArticleDOI
Translocation of c- abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia
Claus R. Bartram,Annelies de Klein,Anne Hagemeijer,Ton van Agthoven,Ad Geurts van Kessel,Dirk Bootsma,Gerard Grosveld,Malcolm A. Ferguson-Smith,Teresa Davies,Marion Stone,Nora Heisterkamp,John R. Stephenson,John Groffen +12 more
TL;DR: In this article, the translocation of the human cellular homologue (c-ab1) of the transforming sequence of Abelson murine leukaemia virus (A-MuLV) from chromosome 9 to the Philadelphia chromosome (Ph1) in chronic myelocytic leukemiaemia (CML) was investigated.
Journal ArticleDOI
A General Theory of Carcinogenesis
TL;DR: It is suggested that all cells possess multiple structural genes capable of coding for transforming factors which can release the cell from its normal constraints on growth.
References
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Journal ArticleDOI
A histochemical procedure for localizing and evaluating leukocyte alkaline phosphatase activity in smears of blood and marrow.
TL;DR: Alkaline phosphatase activity was found only in neutrophilic granulocytes and was localized exclusively in the cytoplasm of these cells.
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Chromosome Studies in Human Leukemia. II. Chronic Granulocytic Leukemia
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Cytogenetic studies on bone-marrow in chronic myeloid leukaemia.
Journal ArticleDOI
Clinical Implications of Cytogenetic Variants in Chronic Myelocytic Leukemia (CML)
TL;DR: The development of other chromosomal abnormalities in Ph1 positive patients presaged the terminal stage of the disease.
Journal ArticleDOI
Leukemia in Hiroshima Atomic Bomb Survivors
Robert Heyssel,A. Bertrand Brill,Lowell A. Woodbury,Edwin T. Nishimura,Tarunendu Ghose,Takashi Hoshino,Mitsuru Yamasaki +6 more
TL;DR: The incidence of leukemia is higher among those closely exposed than among those more remote from the hypocenter as mentioned in this paper and the type of leukemia most increased in incidence is the chronic granulocytic variety.