Journal ArticleDOI
Phosphatonins and the regulation of phosphate homeostasis.
Theresa J. Berndt,Rajesh Kumar +1 more
TLDR
A review examines the role of peptide and sterol hormones in P(i) homeostasis in health and disease as discussed by the authors, showing that peptides such as fibroblast growth factor-23 (FGF-23), secreted frizzled related protein-4 (sFRP-4), matrix extracellular phosphoglycoprotein (MEP), and fibrobl growth factor 7 (FG-7) play a pathogenic role in several hypophosphatemic disorders.Abstract:
Inorganic phosphate (P(i)) is required for energy metabolism, nucleic acid synthesis, bone mineralization, and cell signaling The activity of cell-surface sodium-phosphate (Na(+)-P(i)) cotransporters mediates the uptake of P(i) from the extracellular environment Na(+)-P(i) cotransporters and organ-specific P(i) absorptive processes are regulated by peptide and sterol hormones, such as parathyroid hormone (PTH) and 1alpha,25-dihydroxyvitamin D (1alpha,25(OH)(2)D(3)), which interact in a coordinated fashion to regulate P(i) homeostasis Recently, several phosphaturic peptides such as fibroblast growth factor-23 (FGF-23), secreted frizzled related protein-4 (sFRP-4), matrix extracellular phosphoglycoprotein, and fibroblast growth factor-7 have been demonstrated to play a pathogenic role in several hypophosphatemic disorders By inhibiting Na(+)-P(i) transporters in renal epithelial cells, these proteins increase renal P(i) excretion, resulting in hypophosphatemia FGF-23 and sFRP-4 inhibit 25-hydroxyvitamin D 1alpha-hydroxylase activity, reducing 1alpha,25(OH)(2)D(3) synthesis and thus intestinal P(i) absorption This review examines the role of these factors in P(i) homeostasis in health and diseaseread more
Citations
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Journal ArticleDOI
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease.
Paola Bovolenta,Pilar Esteve,Pilar Esteve,José María García Ruiz,José María García Ruiz,Elsa Cisneros,Elsa Cisneros,Javier Lopez-Rios +7 more
TL;DR: These studies indicate that SFRPs are not merely Wnt-binding proteins, but can also antagonise one another's activity, bind to Fz receptors and influence axon guidance, interfere with BMP signalling by acting as proteinase inhibitors, and interact with other receptors or matrix molecules.
Journal ArticleDOI
Renal Control of Calcium, Phosphate, and Magnesium Homeostasis
TL;DR: Renal regulation of these ions occurs through glomerular filtration and tubular re absorption and/or secretion and is therefore an important determinant of plasma ion concentration.
Journal ArticleDOI
Regulation and Function of the FGF23/Klotho Endocrine Pathways
TL;DR: FGF23 participates in a new bone/kidney axis that protects the organism from excess vitamin D and coordinates renal PO(4)(3-) handling with bone mineralization/turnover, as well as the implications in different pathological and physiological contexts.
Journal ArticleDOI
Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism
TL;DR: This review covers recent data on the physiological regulation and function of the complex FGF23-αKlotho network.
Journal ArticleDOI
The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis
TL;DR: How the endocrine effects of bone-derived FGF23, in coordination with Klotho, can regulate systemic phosphate homeostasis, and how an inadequate balance of these molecules can lead to complications that are caused by abnormal mineral ion metabolism are summarized.
References
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Journal ArticleDOI
The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
Journal ArticleDOI
The structure and regulation of protein phosphatases
TL;DR: Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells and have broad and overlapping specificities in vitro, and account for virtually all measurable activity in tissue extracts toward a variety of phosphoproteins that regulate metabolism, muscle contractility, and other processes.
Journal ArticleDOI
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
Kenneth E. White,Wayne E. Evans,Jeffery L.H. O'Riordan,Marcy C. Speer,Michael J. Econs,Bettina Lorenz-Depiereux,Bettina Lorenz-Depiereux,Monika Grabowski,Monika Grabowski,Thomas Meitinger,Thomas Meitinger,Tim M. Strom +11 more
TL;DR: A positional cloning approach was used to identify the ADHR gene which included the annotation of 37 genes within 4 Mb of genomic sequence, and missense mutations in a gene encoding a new member of the fibroblast growth factor (FGF) family, FGF23 were identified.