Journal ArticleDOI
Photophysical behavior of a new cholesterol attached coumarin derivative and fluorescence spectroscopic studies on its interaction with bile salt systems and lipid bilayer membranes
TLDR
It is seen that in such aqueous micro- and nanoscale organized media like bile salts and lipid bilayer membranes the monomer-to-aggregate fluorescence intensity ratio reflects the state of organization of the medium.Abstract:
A new fluorescent-cholesterol (Cum-Chl) molecule has been synthesized by attaching 3-acetyl-7-(diethylamino)-2H-chromen-2-one (Cum) to cholesterol via cholesterol bound β-keto ester. The β-keto ester was synthesized from the corresponding nitrile by applying the Blaise reaction. The molecule forms H-aggregates in solutions. The efficiency of aggregation is high in water. The H-aggregates are non-fluorescent in non-aqueous solvents but fluorescent in water. Aqueous bile salt media suppress the formation of H-aggregates, this effect being more pronounced for sodium deoxycholate (NaDC) which is more hydrophobic. With increasing bile salt concentration, the enhancement of monomeric fluorescence intensity of Cum-Chl generally follows the progressive miceller aggregation of bile salts. Incorporation of Cum-Chl into the dimyristoylphosphatidylcholine (DMPC) lipid bilayer membrane results in a significant enhancement of monomeric fluorescence intensity. The variation of fluorescence intensity is also sensitive to the thermotropic phase transition of the bilayer. It is seen that in such aqueous micro- and nanoscale organized media like bile salts and lipid bilayer membranes the monomer-to-aggregate fluorescence intensity ratio reflects the state of organization of the medium.read more
Citations
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Niosomes: A review on niosomal research in the last decade
TL;DR: In the last one-decade numbers of review and research, articles have been published on niosomes as discussed by the authors, which shows the interest of researchers in Niosomes because of the advantages offered by them over other vesicular carrier systems.
Journal ArticleDOI
Chitosan Glutamate-Coated Niosomes: A Proposal for Nose-to-Brain Delivery.
Federica Rinaldi,Patrizia Nadia Hanieh,Lik King Nicholas Chan,Livia Angeloni,Daniele Passeri,Marco Rossi,Julie Tzu-Wen Wang,Anna Imbriano,Maria Carafa,Carlotta Marianecci +9 more
TL;DR: The characteristics of the proposed systems, such aspentamidine entrapment and mucin interaction, show promising results to deliver pentamidine or other possible drugs to the brain via nasal administration.
Journal ArticleDOI
Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical-Chemical Characterization in View of Biological Applications.
Federica Rinaldi,Elena Del Favero,Johannes Moeller,Patrizia Nadia Hanieh,Daniele Passeri,Marco Rossi,Livia Angeloni,Iole Venditti,Carlotta Marianecci,Maria Carafa,Ilaria Fratoddi +10 more
TL;DR: Two systems were functionalized with sodium 3-mercapto-1-propanesulfonate to induce hydrophilic behavior, improving loading in Tween 20 and Span 20 niosomes and suitable and promising in the field of biological applications are concluded.
Journal ArticleDOI
Fluorescence of N-acylated dansylamide with a long hydrophobic tail: sensitive response to premicellar aggregation of sodium deoxycholate
TL;DR: The long chain tethered dansylamide derivative is successfully utilized in estimating critical micellar concentration (CMC) of bile salts as well as anionic and cationic surfactants (SDS, CTAB) with the help of enhanced fluorescence intensity facilitated by better solubilization of the molecule in microheterogeneous media.
Journal ArticleDOI
Development of a thermal-stable structure-switching cocaine-binding aptamer
Aron A. Shoara,Oren Reinstein,Okty Abbasi Borhani,Taylor R. Martin,Sladjana Slavkovic,Zachary R. Churcher,Philip E. Johnson +6 more
TL;DR: A new cocaine-binding aptamer variant that has a significantly higher melt temperature when bound to a ligand than the currently used sequence is developed and should make it a useful construct for sensing applications employing the cocaine- binding aptamer system.
References
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Book
Liposomes : a practical approach
TL;DR: Cossins liposomes in biological systems, R.R.C.Jones and A.J.Martin physical methods of study and new liposome characterization.
Journal ArticleDOI
Cyanines during the 1990s: A Review
Journal ArticleDOI
Solvent effects on emission yield and lifetime for coumarin laser dyes. Requirements for a rotatory decay mechanism
TL;DR: In this paper, photophysical parameters have been determined for coumarin laser dyes in a variety of organic solvents, water, and mixed media, showing that substituent influences resulted in enlarged excited-state dipole moments for the fluorescent state.
Journal ArticleDOI
Cholesterol interactions with phospholipids in membranes.
TL;DR: This review is mainly focused on two of the major classes of membrane phospholipids in eukaryotic organisms, sphingomyelins and phosphatidylcholines, and the synthesis and distribution in the cell of these lipids, how they are believed to interact with each other, and what cellular consequences such interactions may have.
Solvent effects on emission yield and lifetime for coumarin laser dyes. Requirements for a rotatory decay mechanism
TL;DR: In this paper, photophysical parameters have been determined for coumarin laser dyes in a variety of organic solvents, water, and mixed media, showing that substituent influences resulted in enlarged excited-state dipole moments for the fluorescent state.