Physical activity and colon cancer prevention: a meta-analysis.
TLDR
This study confirms previous studies reporting an inverse association between physical activity and colon cancer in both men and women, and provides quantitative estimates of the inverse association.Abstract:
Although an inverse association between physical activity and risk of colon cancer is well established, a formal estimate of the magnitude of this risk reduction that includes recent studies is not available. This analysis examines the association by sex and study design, restricting analyses to studies where data for colon cancer alone were available. The authors reviewed published studies through June 2008 examining the association between physical activity and risk of colon cancer. Heterogeneity and publication bias were evaluated and random effects models used to estimate relative risks (RR). Differences by sex and study design were evaluated. A total of 52 studies were included. An inverse association between physical activity and colon cancer was found with an overall relative risk (RR) of 0.76 (95% confidence interval (CI): 0.72, 0.81). For men, the RR was 0.76 (95% CI: 0.71, 0.82); for women, this was little different, (RR=0.79, 95% CI: 0.71, 0.88). The findings from case–control studies were stronger (RR=0.69, 95% CI: 0.65, 0.74) than for cohort studies (RR=0.83, 95% CI: 0.78, 0.88). This study confirms previous studies reporting an inverse association between physical activity and colon cancer in both men and women, and provides quantitative estimates of the inverse association.read more
Citations
More filters
Journal ArticleDOI
Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
TL;DR: In this article, the authors quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level.
Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
TL;DR: In this article, the authors quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level.
Journal ArticleDOI
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases
TL;DR: This review provides the reader with the up‐to‐date evidence‐based basis for prescribing exercise as medicine in the treatment of 26 different diseases: psychiatric diseases (depression, anxiety, stress, schizophrenia).
Journal ArticleDOI
Muscles, exercise and obesity: skeletal muscle as a secretory organ
TL;DR: The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs, such as adipose tissue, liver, pancreas, bones and brain.
Journal ArticleDOI
The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012.
Su-Hsin Chang,Carolyn R. T. Stoll,Jihyun Song,Jihyun Song,J. Esteban Varela,Christopher J. Eagon,Graham A. Colditz +6 more
TL;DR: Bariatric surgery provides substantial and sustained effects on weight loss and ameliorates obesity-attributable comorbidities in the majority of bariatric patients, although risks of complication, reoperation, and death exist.
References
More filters
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
Journal ArticleDOI
The Department of Health and Human Services.
TL;DR: This letter is in response to your two Citizen Petitions, requesting that the Food and Drug Administration (FDA or the Agency) require a cancer warning on cosmetic talc products.
Journal ArticleDOI
Comparison of risk factors for colon and rectal cancer
Esther K. Wei,Edward Giovannucci,Edward Giovannucci,Kana Wu,Bernard Rosner,Bernard Rosner,Charles S. Fuchs,Charles S. Fuchs,Walter C. Willett,Walter C. Willett,Graham A. Colditz,Graham A. Colditz +11 more
TL;DR: The findings support previous suggestions that family history and physical activity are not strong contributors to the etiology of rectal cancer and should take into consideration risk factor differences by subsite.
Journal ArticleDOI
Sugar, meat, and fat intake, and non-dietary risk factors for colon cancer incidence in Iowa women (United States)
Roberd M. Bostick,John D. Potter,Lawrence H. Kushi,Thomas A. Sellers,Kristi A. Steinmetz,David R. McKenzie,Susan M. Gapstur,Aaron R. Folsom +7 more
TL;DR: In this paper, the relation of dietary intake of sucrose, meat, and fat, and anthropometric, lifestyle, hormonal, and reproductive factors to colon cancer incidence was investigated from a prospective cohort study of 35,215 Iowa women, aged 55-69 years and without a history of cancer, who completed mailed dietary and other questionnaires in 1986.