PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes
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TLDR
Pacheco et al. as mentioned in this paper demonstrate that unbound PI(4,5)P2 diffusion in the PM is rapid and is not slowed by the majority of P2-dependent PM complexes, such as clathrin-coated structures and focal adhesions.Abstract:
Pacheco et al. demonstrate that unbound PI(4,5)P2 diffusion in the PM is rapid and is not slowed by the majority of PI(4,5)P2-dependent PM complexes found there, such as clathrin-coated structures and focal adhesions.read more
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Posted ContentDOI
A Novel Homeostatic Mechanism Tunes PI(4,5)P2-dependent Signaling at the Plasma Membrane
Rachel C. Wills,Colleen P. Doyle,James P. Zewe,Jonathan Pacheco,Scott D. Hansen,Gerald R.V. Hammond +5 more
TL;DR: It is shown that the PIP4K family of enzymes that synthesize PI( 4,5)P2 via a minor pathway, also function as sensors of tonic PI(4,5]P2 levels, inactivating synthesis of the lipid via the major PIP5K-catalyzed pathway when PI(3,4)P1 levels rise.
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