PIP2 is a necessary cofactor for ion channel function: how and why?
Byung-Chang Suh,Bertil Hille +1 more
TLDR
This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.Abstract:
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.read more
Citations
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Journal ArticleDOI
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
TL;DR: This review is an attempt to give an overview of this enormous research field focusing on major developments in diverse areas of basic science linked to cellular physiology and disease.
Journal ArticleDOI
Hyperpolarization-activated cation channels: from genes to function.
TL;DR: Recent insights into the structure, function, and cellular regulation of HCN channels are summarized and evidence on the role of individual HCN channel types arising from the analysis ofHCN knockout mouse models is discussed.
Journal ArticleDOI
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Yves Dondelinger,Wim Declercq,Sylvie Montessuit,Ria Roelandt,Amanda Gonçalves,Inge Bruggeman,Paco Hulpiau,Kathrin Weber,Clark A. Sehon,Robert W. Marquis,John Bertin,Peter J. Gough,Savvas N. Savvides,Jean-Claude Martinou,Mathieu J.M. Bertrand,Peter Vandenabeele +15 more
TL;DR: It is demonstrated that the full four-helical bundle domain (4HBD) in the N-terminal region of MLKL is required and sufficient to induce its oligomerization and trigger cell death, and found that a patch of positively charged amino acids on the surface of the 4HBD binds to phosphatidylinositol phosphates (PIPs) and allows recruitment ofMLKL to the plasma membrane.
Journal ArticleDOI
hERG K+ Channels: Structure, Function, and Clinical Significance
TL;DR: The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which is the gene product involved in chromosome 7-associated long QT syndrome (LQTS), an inherited disorder associated with a markedly increased risk of ventricular arrhythmias and sudden cardiac death.
Journal ArticleDOI
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
Xian-Ping Dong,Dongbiao Shen,Xiang Wang,Taylor Dawson,Xinran Li,Qi Zhang,Xiping Cheng,Yanling Zhang,Lois S. Weisman,Markus Delling,Haoxing Xu +10 more
TL;DR: It is proposed that TRPMLs regulate membrane trafficking by transducing information regarding PI(3,5)P(2) levels into changes in juxtaorganellar Ca(2+), thereby triggering membrane fusion/fission events.
References
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Journal ArticleDOI
Phosphoinositides in cell regulation and membrane dynamics
TL;DR: Inositol phospholipids mediate acute responses, but also act as constitutive signals that help define organelle identity, and play a fundamental part in controlling membrane–cytosol interfaces.
Journal ArticleDOI
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
TL;DR: These findings, together with the previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
Journal ArticleDOI
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.
Cecilia M. Canessa,Laurent Schild,Gary Buell,Bernard Thorens,Ivan Gautschi,Jean-Daniel Horisberger,Bernard C. Rossier +6 more
TL;DR: The ion-selective permeability, the gating properties and the pharmacological profile of the channel formed by coexpressing the three subunits in oocytes are similar to that of the native channel.
Journal ArticleDOI
An Introduction to TRP Channels
TL;DR: The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated in heterologous expression systems.
Journal ArticleDOI
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.
Huai-hu Chuang,Elizabeth D. Prescott,Haeyoung Kong,Shannon D. Shields,Sven-Eric Jordt,Allan I. Basbaum,Moses V. Chao,David Julius +7 more
TL;DR: It is shown that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons, and biochemical studies suggest that VR1 associates with this complex.