Placenta-derived stem cells: new hope for cell therapy?
TLDR
A snapshot of current knowledge regarding the potential of cells from the amniotic membrane of human term placenta to address current shortcomings in the field of regenerative medicine is provided.Abstract:
An urgent current need in regenerative medicine is that of identifying a plentiful, safe and ethically acceptable stem cell source for the development of therapeutic strategies to restore functionality in damaged or diseased organs and tissues. In this context, human term placenta represents a prime candidate, as it is available in nearly unlimited supply, is ethically problem-free and easily procured. Placental cells display differentiation capacity toward all three germ layers, while also displaying immunomodulatory effects, therefore supporting the possibility that they could be applied in an allogeneic transplantation setting. Although promising data have been reported to date, further study is required to fully characterize the differentiation potential of placenta-derived cells and to identify their possible clinical applications. Here, we provide a snapshot of current knowledge regarding the potential of cells from the amniotic membrane of human term placenta to address current shortcomings in the field of regenerative medicine.read more
Citations
More filters
Journal ArticleDOI
Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue.
Susanne Wolbank,Anja Peterbauer,Marc Fahrner,Simone Hennerbichler,Martijn van Griensven,Guido Stadler,Heinz Redl,Christian Gabriel +7 more
TL;DR: This study demonstrates, for the first time, contact- and dose-dependent immunosuppression of mesenchymal and epithelial amniotic SC populations, as well as of adipose tissue-derived SCs.
Journal ArticleDOI
Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue
TL;DR: Investigation of the immunophenotype, proliferative potential, multilineage differentiation and immunomodulatory capacity of MSCs derived from different tissue sources suggest that BM-MSCs and adipose tissue-derived M SCs (A- MSCs) represent the optimal stem cell source for tissue engineering and regenerative medicine.
Journal ArticleDOI
Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study
Ranhua Jiang,Zhibo Han,Guangsheng Zhuo,Xiaodan Qu,Xue Li,Xin Wang,Yuankang Shao,Shimin Yang,Zhongchao Han +8 more
TL;DR: The results obtained from this pilot clinical trial indicate that transplantation of PD-MSC represents a simple, safe and effective therapeutic approach for T2D patients with islet cell dysfunction.
Journal ArticleDOI
Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells.
TL;DR: CP-MSCs may have additional advantage over the other MSCs in terms of immunomodulation, and in conjunction with other previous studies, they are suggested to be a useful stem cell source in cell therapy.
Journal ArticleDOI
On the origin of amniotic stem cells: of mice and men.
TL;DR: Some fundamental differences in amnion development in the disc-shaped primate embryo and in the cup-shaped mouse embryo are discussed, and striking differences in the sources used to derive these cells across studies are revealed.
References
More filters
Book
The Developing Human: Clinically Oriented Embryology
TL;DR: In this article, the development of the developing human can be traced to the beginning of human development: first week 3. Formation of Bilaminar Embryonic Disc (BED) and the formation of Germ Layers and early Tissue and Organ Differentiation: Third week 5. Organogenetic Period: Fourth to Eighth weeks 6. The Fetal Period: Ninth week to birth 7. Placenta and Fetal Membranes 8. Body Cavities, Mesenteries, and Diaphragm
Book
Pathology of the human placenta
Kurt Benirschke,Peter Kaufmann +1 more
TL;DR: Early development of the human placenta and histopathologic approach to villous alterations are studied.
Developing human : clinically oriented embryology
Keith L. Moore,T. V. N. Persaud +1 more
TL;DR: The Beginning of Human Development: The First Week and Critical Periods in Human Development Index, which summarizes the four major periods of human development, are explained.
Journal ArticleDOI
Isolation of Mesenchymal Stem Cells of Fetal or Maternal Origin from Human Placenta
Pieternella S. in `t Anker,Sicco A. Scherjon,Carin Kleijburg-van der Keur,Godelieve M.J.S. de Groot-Swings,Frans H.J. Claas,Willem E. Fibbe,Humphrey H.H. Kanhai +6 more
TL;DR: It is reported that second‐trimester amniotic fluid (AF) is an abundant source of fetal mesenchymal stem cells (MSCs), and different parts of the human placenta were studied for the presence of either fetal or maternal MSCs.
Journal ArticleDOI
Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells.
Ornella Parolini,Francesco Alviano,Gian Paolo Bagnara,Grozdana Bilic,Hans-Jörg Bühring,Marco Evangelista,Simone Hennerbichler,Bing Liu,Marta Magatti,Ning Mao,Toshio Miki,Fabio Marongiu,Hideaki Nakajima,Toshio Nikaido,C. Bettina Portmann-Lanz,Venkatachalam Sankar,Maddalena Soncini,Guido Stadler,Daniel Surbek,Tsuneo A. Takahashi,Heinz Redl,Norio Sakuragawa,Susanne Wolbank,Steffen M. Zeisberger,Andreas H. Zisch,Stephen C. Strom +25 more
TL;DR: The aim of this review is to summarize and provide the state of the art of research in this field, addressing aspects such as cell isolation protocols and characteristics of these cells, as well as providing preliminary indications of the possibilities for use ofThese cells in future clinical applications.
Related Papers (5)
Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells.
Ornella Parolini,Francesco Alviano,Gian Paolo Bagnara,Grozdana Bilic,Hans-Jörg Bühring,Marco Evangelista,Simone Hennerbichler,Bing Liu,Marta Magatti,Ning Mao,Toshio Miki,Fabio Marongiu,Hideaki Nakajima,Toshio Nikaido,C. Bettina Portmann-Lanz,Venkatachalam Sankar,Maddalena Soncini,Guido Stadler,Daniel Surbek,Tsuneo A. Takahashi,Heinz Redl,Norio Sakuragawa,Susanne Wolbank,Steffen M. Zeisberger,Andreas H. Zisch,Stephen C. Strom +25 more