Showing papers in "International Immunopharmacology in 2012"

TL;DR: The present results suggest that the anti-inflammatory effect of ampelopsin is due to inhibiting the interconnected ROS/Akt/IKK/NF-κB signaling pathways.

TL;DR: CP-MSCs may have additional advantage over the other MSCs in terms of immunomodulation, and in conjunction with other previous studies, they are suggested to be a useful stem cell source in cell therapy.

TL;DR: Results suggest that alantolactone exerts its anti-inflammatory effect in LPS-stimulated RAW 264.7 cells by suppressing NF-κB activation and MAPKs phophorylation via downregulation of the MyD88 signaling pathway, and may provide a useful therapeutic approach for inflammation-associated diseases.

TL;DR: EF31 represents a promising curcumin analog for further therapeutic development and demonstrated potent toxicity in NF-κB-dependent cancer cell lines while having minimal and reversible toxicity in RAW264.7 macrophages.

TL;DR: SSa and SSd showed potent anti-inflammatory activity through inhibitory effects on NF-κB activation and thereby on iNOS, COX-2 and pro-inflammatory cytokines.

TL;DR: The results suggest that the oral administration of LM-COS is effective in alleviating the allergic inflammation in vivo and thus can be a good source material for the development of a potent therapeutic agent against mast cell-mediated allergic inflammatory responses and airway inflammation in allergic inflammatory diseases, including asthma.

TL;DR: The results suggest that Kae exhibits a protective effect on LPS-induced ALI via suppression of MAPKs and NF-κB signaling pathways, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process.

TL;DR: Clinical data show that TGP is effective to relieve the symptoms and signs of rheumatoid arthritis without significant adverse effects.

TL;DR: It is found that the mice treated with dendrosomal curcumin, showed a significant increase in splenocyte proliferation and IFN-γ production as well as a significant decrease in IL-4 production, which can be a proof of anti-tumor immunity caused by dendosomal cur cumin.

TL;DR: Ar-turmerone impaired the Aβ-induced inflammatory response of microglial cells by inhibiting the NF-κB, JNK, and p38 MAPK signaling pathways, which provide new insights into the development of ar-Turmerone as a therapeutic agent for the treatment of neurodegenerative disorders.

TL;DR: In the mouse model of LPS-induced acute lung injury, pinocembrin attenuated the development of pulmonary edema, histological severities, as well as neutrophil, lymphocyte and macrophage infiltration, which were increased by LPS administration.

TL;DR: The effect of Lf in reducing inflammation and destabilizing Gram negative bacteria has clinical implications in the control of sepsis, multiple organ dysfunction and bacterial invasion.

TL;DR: The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods to be helpful to beginners as well as experts working in the field of allergy and immunology.

TL;DR: The potential beneficiary effect of fenugreek mucilage on adjuvant induced arthritis in rats was demonstrated and the increment in ESR and total WBC, reduction in RBC count and hemoglobin and aberrant changes to the C-reactive protein (CRP) levels observed in the arthritic animals were also found to be significantly restored in fenuvant treated rats.

TL;DR: The pro-apoptotic effect of wogonin is mediated through the activation of ERK and theactivation of caspases, and is correlated with the block of the PI3K/Akt/survivin signal pathways in MCF-7 cells.

TL;DR: Findings suggest that APS is a potent adjuvant for the hepatitis B DNA vaccine and can enhance the immune responses of HBV DNA vaccine via promoting DC maturation and inhibit the Treg frequency.

TL;DR: Results suggest that geniposide exerts an anti-inflammatory property by down-regulating the expression of TLR4 up-regulated by LPS, a promising potential therapeutic reagent for acute lung injury treatment.

TL;DR: The compound, zerumbone inhibits both cancer cell growth through the induction of apoptosis, arrests cell cycle at G2/M phase and inhibits the secretion levels of IL-6 in both cancer cells.

TL;DR: Observations suggest that microRNA-181a, -146a and -146b are proinflammatory factors in asthma, and that down-regulation of miRNA-146a may partially account for the anti-inflammatory effect of dexamethasone.

TL;DR: Lycorine dose-dependently inhibited the LPS-induced up-regulation of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells and increases the survival rate of mice after LPS challenge, suggesting that lycorine could play an anti-inflammatory role in response to LPS.

TL;DR: Rg5 can ameliorate lung inflammation possibly by inhibiting the binding of LPS to toll-like receptor (TLR)-4 on macrophages and on LPS-induced lung inflammation.

TL;DR: The results suggest that curcumin pretreatment protects against T cell-mediated hepatitis in mice, and may be partly mediated by inhibiting the expression levels of TLR2, TLR4 and TLR9 in the liver.

TL;DR: The data suggest that the anti-inflammatory properties of 6,6'-bieckol are related to the down-regulation of iNOS, COX-2, and pro-inflammatory cytokines through the negative regulation of the NFκB pathway in LPS-stimulated macrophages.

TL;DR: Results suggest that baicalin has anti-inflammatory effects in cigarette smoke induced inflammatory models in mice and A549 cells, possibly achieved by modulating HDAC2.

TL;DR: Experimental data provide mechanistic insights for the anti-inflammatory actions of cardamonin in BV2 and suggest a possible therapeutic application of Cardamonin for targeting neuroinflammatory disorders.

TL;DR: Results provide insights into the role of phagocytes-derived oxidants in TNF-α-colitis in mice and suggest that inhibiting neutrophils priming and iNOsynthase could be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response.

TL;DR: The data suggest that IF possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.

TL;DR: It is suggested that naringin exhibited antitussive, anti-AHR and anti-inflammation effects on chronic CS exposure-induced chronic bronchitis in guinea pigs, and may possess novel therapeutic potential in the treatment of chronic Bronchitis.

TL;DR: It is found that TNFα induced mitochondrial dysfunction accompanied with ROS production and cytochrome c release via RIP1, leading to necroptosis and resulting autophagic cell death in murine fibrosarcoma L929 cells.

TL;DR: The data reveal that Art could effectively block CHS response in mice by inducing the generation of Tregs and suppressing the development of Th17, indicating the potential of Art to be applied as an effective therapeutic agent for treating immune-related diseases.