Journal ArticleDOI
Placental passage of metformin in women with polycystic ovary syndrome.
TLDR
Fetal serum levels are comparable with maternal values and metformin passes the placenta, and the levels of these substances are similar to that of a normal pregnancy.About:
This article is published in Fertility and Sterility.The article was published on 2005-05-01. It has received 188 citations till now. The article focuses on the topics: Polycystic ovary & Metformin.read more
Citations
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Journal ArticleDOI
Gestational Diabetes Mellitus
TL;DR: This review provides an overview of current controversies as well as current recommendations for gestational diabetes care and the recommendations of a number of professional organizations.
Journal ArticleDOI
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
TL;DR: The uses of metformin are analyzed not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome.
Journal ArticleDOI
Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
TL;DR: This review attempts to cover the spectrum of metformin's cellular actions in different tissues and to summarize the current literature regarding the potential medical value of this medication in PCOS.
Journal ArticleDOI
Pharmacokinetics of Metformin during Pregnancy
Sara Eyal,Thomas R. Easterling,Darcy B. Carr,Jason G. Umans,Menachem Miodovnik,Gary D.V. Hankins,Shannon M. Clark,Linda J. Risler,Joanne Wang,Edward J. Kelly,Danny D. Shen,Mary F. Hebert +11 more
TL;DR: The results indicate that metformin pharmacokinetics are affected by pregnancy-related changes in renal filtration and net tubular transport and can be roughly estimated by the use of creatinine clearance.
Journal ArticleDOI
The Human Placental Perfusion Model: A Systematic Review and Development of a Model to Predict In Vivo Transfer of Therapeutic Drugs
TL;DR: Placental perfusion experiments can be used to predict placental drug transfer when adjusting for extra parameters and can be useful for assessing drug therapy risks and benefits in pregnancy and to develop a pharmacokinetic model to account for nonplacental Pharmacokinetic parameters in the perfusion results.
References
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Journal ArticleDOI
Metformin in polycystic ovary syndrome: systematic review and meta-analysis
TL;DR: Metformin is an effective treatment for anovulation in women with polycystic ovary syndrome and its choice as a first line agent seems justified, and there is some evidence of benefit on variables of the metabolic syndrome.
Journal ArticleDOI
Metformin kinetics in healthy subjects and in patients with diabetes mellitus.
TL;DR: Plasma metformin concentrations measured throughout the seventh and fourteenth days of continuous 0.5 g twice daily treatment were accurately predicted from single dose data, although a discrepancy between observed and predicted trough levels reflected the existence of a slow elimination phase.
Journal ArticleDOI
Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin
TL;DR: Metformin therapy during pregnancy in women with PCOS was safely associated with reduction in SAB and in GD, was not teratogenic, and did not adversely affect birthweight or height, or height and weight, weight, and motor and social development at 3 and 6 months of life.
Journal ArticleDOI
Ovarian Function and Metabolic Factors in Women with Oligomenorrhea Treated with Metformin in a Randomized Double Blind Placebo-Controlled Trial
TL;DR: It is shown in a large randomized placebo-controlled trial that metformin treatment improves ovulation frequency in women with abnormal ovarian function and polycystic ovaries significantly but to a modest degree, and protracted treatment improves cardiovascular risk factors.
Journal ArticleDOI
Pharmacokinetics of metformin after intravenous and oral administration to man.
TL;DR: The kinetics of14C-metformin have been studied in five healthy subjects after oral and intravenous administration, which resulted in a plasma concentration profile of “flip-flop” type for oral metformin.
Related Papers (5)
Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study.
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