Journal ArticleDOI
Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics.
Giuseppe Paolisso,A. D'Amore,V. Balbi,Clelia Volpe,Domenico Galzerano,Dario Giugliano,Saverio Sgambato,Michele Varricchio,Felice D'Onofrio +8 more
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Plasma vitamin C levels seem to play a role in the modulation of insulin action in aged healthy and diabetic subjects.Abstract:
In aged healthy (n = 10) and non-insulin-dependent (type II) diabetic (n = 10) subjects matched for age [67.3 +/- 0.5 vs. 68.0 +/- 0.4 yr, P = not significant (NS)], body mass index (25.7 +/- 0.7 v...read more
Citations
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Journal ArticleDOI
Oxidative Stress and Diabetic Vascular Complications
TL;DR: The suggestion that the different susceptibility of diabetic patients to microvascular and macrovascular complications may be a function of the endogenous antioxidant status is suggested.
Journal ArticleDOI
Plant L‐ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing
Mark W. Davey,M. Van Montagu,Dirk Inzé,Maite Sanmartín,Angelos K. Kanellis,Nicholas Smirnoff,I. J. J. Benzie,John (Sean) J. Strain,D. Favell,J. Fletcher +9 more
TL;DR: The role of L-AA in metabolism and the latest studies regarding its bio- synthesis, tissue compartmentalisation, turnover and catabolism are focused on, as well as the potential to improve the L- AA content of crops.
Journal ArticleDOI
The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society.
TL;DR: This review summarises the results and discussions of an UNESCO‐MCBN supported symposium on oxidative stress and its role in the onset and progression of diabetes and suggests a role for ROI in the development of insulin resistance.
Journal ArticleDOI
Oxidative stress in the pathogenesis of diabetic neuropathy.
TL;DR: Evidence is presented to support the idea that both chronic and acute hyperglycemia cause oxidative stress in the peripheral nervous system that can promote the development of diabetic neuropathy, and it is concluded that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients.
Journal ArticleDOI
Ascorbic acid: Chemistry, biology and the treatment of cancer
TL;DR: It is shown that the chemical and biochemical nature of ascorbate contribute to its antioxidant as well as its prooxidant properties, and recent pharmacokinetic data indicate that intravenous (i.v.) administration of asCorbate bypasses the tight control of the gut producing highly elevated plasma levels.
References
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Oxygen Radicals and Human Disease
Carroll E. Cross,Barry Halliwell,Edward T. Borish,William A. Pryor,Bruce N. Ames,Robert L. Saul,Joe M. McCORD,Denham Harman +7 more
TL;DR: Attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging, which may well provide a firm foundation for therapeutic breakthroughs in oxy-radical research.
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The theoretical bases of indirect calorimetry: a review
TL;DR: The theoretical bases of indirect calorimetry are reviewed in a detailed and orderly fashion and special cases, such as the occurrence of net lipid synthesis or gluconeogenesis, are formally considered with derivation of explicit stoichiometric equations.
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Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study.
TL;DR: This study validated further the bioelectrical impedance analysis (BIA) method for body composition estimation and indicated that the precision of predicting LBM from impedance can be enhanced by sex- and fatness-specific equations.
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New concepts in the biology and biochemistry of ascorbic acid.
TL;DR: It was not until 1753 that a Scottish physician, James Lind, systematically described scurvy and its prevention by dietary means, and for four decades the British navy refused to accept Lind's findings, and countless sailors continued to die unnecessarily from scurvard until lemon juice was finally included in sailors' rations.
Book ChapterDOI
Fluidity of cell membranes--current concepts and trends.
M. Shinitzky,P. Henkart +1 more
TL;DR: The dynamics and organization of lipid assemblies derives from studies of model lipid membranes of well-defined chemical composition, but because of the heterogeneity in both the lipid composition and in the acyl chains of single phospholipids, extrapolations from the model system can only be qualitative in nature.