Journal ArticleDOI
Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines.
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TLDR
The adjuvant effect of PLG microparticles are discussed, and their potential for the development of single-dose vaccines through the use of controlled-release technology is discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 1998-07-06. It has received 257 citations till now. The article focuses on the topics: Adjuvant.read more
Citations
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Recent Developments in Ring Opening Polymerization of Lactones for Biomedical Applications
TL;DR: This review presents the various methods of the synthesis of polyesters and tailoring the properties by proper control of molecular weight, composition, and architecture so as to meet the stringent requirements of devices in the medical field.
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Cancer vaccines: between the idea and the reality.
TL;DR: The common and the unique challenges to cancer vaccines and the progress that has been made in meeting them are addressed.
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Advances in vaccine adjuvants.
Manmohan Singh,Derek T. O'Hagan +1 more
TL;DR: Of the novel compounds recently evaluated in human trials, immunostimulatory molecules such as the lipopolysaccharide derived MPL and the saponin derivative QS21 appear most promising, although doubts have been raised as to their safety in humans.
Journal ArticleDOI
Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
TL;DR: This review examines several impediments to PLGA microparticle development, such as PLGA-encapsulated antigen instability and deficiency of animal models in predicting human response, and describes new trends in overcoming these important issues.
Journal ArticleDOI
Recent developments in adjuvants for vaccines against infectious diseases.
TL;DR: The discovery of more potent adjuvants may allow the development of vaccines against infectious agents such as HIV which do not naturally elicit protective immunity and may also allow vaccines to be delivered mucosally.
References
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Journal ArticleDOI
New methods of drug delivery.
TL;DR: Conventional forms of drug administration generally rely on pills, eye drops, ointments, and intravenous solutions, but a number of novel drug delivery approaches have been developed, which may revolutionize the way many drugs are delivered.
Patent
Continuous release pharmaceutical compositions
TL;DR: In this paper, a polylactide and a pharmacologically active acid stable polypeptide are combined in an essentially monophasic manner, with a minimal, or no induction period prior to the release.
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A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
TL;DR: It is demonstrated that M phi s transfer Ags from phagosomes into the cytosol and that endogenous and exogenous Ags use a final common pathway for class I presentation.
Journal ArticleDOI
Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence.
TL;DR: Ageing of large size plates and millimetric beads showed that devices with dimensions smaller than the thickness of the outer layer should degrade less rapidly than larger ones, and heterogeneously and faster than homogeneously degraded submillimetric films and particles.