Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk.
Cinta Valls-Pedret,Rosa M. Lamuela-Raventós,Rosa M. Lamuela-Raventós,Alexander Medina-Remón,Alexander Medina-Remón,Melibea Quintana,Dolores Corella,Dolores Corella,Xavier Pintó,Miguel Ángel Martínez-González,Miguel Ángel Martínez-González,Ramon Estruch,Ramon Estruch,Emilio Ros +13 more
Reads0
Chats0
TLDR
Increased consumption of antioxidant-rich foods in general and of polyphenols in particular is associated with better cognitive performance in elderly subjects at high cardiovascular risk, and the results reinforce the notion that Mediterranean diet components might counteract age-related cognitive decline.Abstract:
Brain oxidative processes play a major role in age-related cognitive decline, thus consumption of antioxidant-rich foods might help preserve cognition. Our aim was to assess whether consumption of antioxidant-rich foods in the Mediterranean diet relates to cognitive function in the elderly. In asymptomatic subjects at high cardiovascular risk (n = 447; 52% women; age 55-80 y) enrolled in the PREDIMED study, a primary prevention dietary-intervention trial, we assessed food intake and cardiovascular risk profile, determined apolipoprotein E genotype, and used neuropsychological tests to evaluate cognitive function. We also measured urinary polyphenols as an objective biomarker of intake. Associations between energy-adjusted food consumption, urinary polyphenols, and cognitive scores were assessed by multiple linear regression models adjusted for potential confounders. Consumption of some foods was independently related to better cognitive function. The specific associations [regression coefficients (95% confidence intervals)] were: total olive oil with immediate verbal memory [0.755 (0.151-1.358)]; virgin olive oil and coffee with delayed verbal memory [0.163 (0.010-0.316) and 0.294 (0.055-0.534), respectively]; walnuts with working memory [1.191 (0.061-2.322)]; and wine with Mini-Mental State Examination scores [0.252 (0.006-0.496)]. Urinary polyphenols were associated with better scores in immediate verbal memory [1.208 (0.236-2.180)]. Increased consumption of antioxidant-rich foods in general and of polyphenols in particular is associated with better cognitive performance in elderly subjects at high cardiovascular risk. The results reinforce the notion that Mediterranean diet components might counteract age-related cognitive decline.read more
Citations
More filters
Journal ArticleDOI
Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial
Cinta Valls-Pedret,Cinta Valls-Pedret,Aleix Sala-Vila,Aleix Sala-Vila,Mercè Serra-Mir,Mercè Serra-Mir,Dolores Corella,Dolores Corella,Rafael de la Torre,Miguel Ángel Martínez-González,Miguel Ángel Martínez-González,Elena H. Martinez-Lapiscina,Elena H. Martinez-Lapiscina,Montserrat Fitó,Ana Pérez-Heras,Ana Pérez-Heras,Jordi Salas-Salvadó,Ramon Estruch,Ramon Estruch,Emilio Ros,Emilio Ros +20 more
TL;DR: In an older population, a Mediterranean diet supplemented with olive oil or nuts is associated with improved cognitive function, and this work is likely to be a first step towards addressing the underlying cause of dementia in patients at high cardiovascular risk.
Journal ArticleDOI
Benefits of the Mediterranean Diet: Insights From the PREDIMED Study
Miguel Ángel Martínez-González,Miguel Ángel Martínez-González,Jordi Salas-Salvadó,Ramon Estruch,Dolores Corella,Montse Fitó,Emilio Ros,Predimed Study Investigators +7 more
TL;DR: The PREDIMED trial provided strong evidence that a vegetable-based MeDiet rich in unsaturated fat and polyphenols can be a sustainable and ideal model for CVD prevention.
Journal ArticleDOI
Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial
Elena H. Martinez-Lapiscina,Pedro Clavero,Estefanía Toledo,Estefanía Toledo,Ramon Estruch,Ramon Estruch,Jordi Salas-Salvadó,Beatriz San Julián,Ana Sánchez-Tainta,Emilio Ros,Cinta Valls-Pedret,Miguel Ángel Martínez-González +11 more
TL;DR: An intervention with MedDiets enhanced with either EVOO or nuts appears to improve cognition compared with a low-fat diet, and results did not differ after controlling for incident depression.
Journal ArticleDOI
The Safety of Ingested Caffeine: A Comprehensive Review.
Jennifer L. Temple,Christophe Bernard,Steven E. Lipshultz,Jason D. Czachor,Joslyn A. Westphal,Miriam A. Mestre +5 more
TL;DR: It is reported that, for healthy adults, caffeine Consumption is relatively safe, but that for some vulnerable populations, caffeine consumption could be harmful, including impairments in cardiovascular function, sleep, and substance use.
Journal ArticleDOI
The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease-A Review
TL;DR: Current scientific evidence suggests that higher adherence to the Mediterranean, DASH, or MIND diets is associated with less cognitive decline and a lower risk of AD, where the strongest associations are observed for the MIND diet.
References
More filters
Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
What is cognitive reserve? Theory and research application of the reserve concept.
TL;DR: This paper attempts to develop a coherent theoretical account of reserve, a distinction is suggested between reserve, the ability to optimize or maximize normal performance, and compensation, an attempt to maximize performance in the face of brain damage by using brain structures or networks not engaged when the brain is not damaged.
Related Papers (5)
Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Ramon Estruch,Emilio Ros,Jordi Salas-Salvadó,María-Isabel Covas,Dolores Corella,Fernando Arós,Enrique Gómez-Gracia,Valentina Ruiz-Gutiérrez,Miquel Fiol,José Lapetra,Rosa M. Lamuela-Raventós,Lluis Serra-Majem,Xavier Pintó,Josep Basora,Miguel A. Muñoz,José V. Sorlí,José Alfredo Martínez,Miguel Ángel Martínez-González +17 more