Journal ArticleDOI
Poor Predictive Value of Serum Creatinine for Renal Allograft Loss
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TLDR
A natural candidate for a surrogate marker for graft loss that has been proposed is renal function (serum creatinine or calculated GFR levels), and a research perspective, it has become increasingly difficult to study the efficacy of new therapies using traditional ‘hard’ endpoints.About:
This article is published in American Journal of Transplantation.The article was published on 2003-12-01. It has received 145 citations till now. The article focuses on the topics: Renal function & Creatinine.read more
Citations
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Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials.
TL;DR: A systematic review of randomized trials where immunosuppressive regimens containingTOR-I were compared with other regimens as initial therapy for kidney transplant recipients found no significant difference in mortality, graft loss, or malignancy risk for TOR-I in any comparison.
Journal ArticleDOI
Calcineurin Inhibitor Minimization in the Symphony Study: Observational Results 3 Years after Transplantation
Henrik Ekberg,Corrado Bernasconi,Helio Tedesco-Silva,Stefan Vitko,Christian Hugo,Alper Demirbas,R Reyes Acevedo,Josep M. Grinyó,Ulrich Frei,Yves Vanrenterghem,Pierre Daloze,Philip F. Halloran +11 more
TL;DR: In the Symphony study, the largest ever prospective study in de novo kidney transplantation, over 3 years, daclizumab induction, MMF, steroids and low‐dose tacrolimus proved highly efficacious, without the negative effects on renal function commonly reported for standard CNI regimens
Journal ArticleDOI
Predicting subsequent decline in kidney allograft function from early surveillance biopsies.
Fernando G. Cosio,Joseph P. Grande,Hani M. Wadei,Timothy S. Larson,Matthew D. Griffin,Mark D. Stegall +5 more
TL;DR: In conclusion, inflammation and glomerulopathy 1 year post‐transplant predict loss of graft function and graft failure independently of function and other variables.
Journal ArticleDOI
Diagnosis and prevention of chronic kidney allograft loss
Brian J. Nankivell,Dirk Kuypers +1 more
TL;DR: In this paper, the authors proposed proactive preventive measures to maintain transplant function and improve long-term graft survival in patients with end-stage renal failure using immunosuppression and calcineurin inhibitor minimization, substitution, or elimination.
Organ Transplantation 3 Diagnosis and prevention of chronic kidney allograft loss
TL;DR: Serial monitoring of renal function enables early recognition of chronic allograft dysfunction, and investigations such as therapeutic drug concentrations, urinalysis, imaging, and a diagnostic biopsy should be undertaken before irreversible nephron loss has occurred.
References
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A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation
TL;DR: The purpose of this study was to develop an equation from MDRD Study data that could improve the prediction of GFR from serum creatinine concentration, and major clinical decisions in general medicine, geriatrics, and oncology are made by using the Cockcroft-Gault formula and other formulas to predict the level of renal function.
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Prediction of Creatinine Clearance from Serum Creatinine
Donald W. Cockcroft,M H Gault +1 more
TL;DR: A formula has been developed to predict Creatinine clearance from serum creatinine (Scr) in adult males: Ccr = (140 – age) (wt kg)/72 × Scr (mg/100ml) (15% less i).
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Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community.
Guruprasad Manjunath,Hocine Tighiouart,Hassan N. Ibrahim,Bonnie MacLeod,Deeb N. Salem,John L. Griffith,Josef Coresh,Andrew S. Levey,Mark J. Sarnak +8 more
TL;DR: The level of GFR is an independent risk factor for ASCVD and de novo ASCVD in the ARIC study, and a nonlinear model did not fit the data better than a linear model.
Journal ArticleDOI
Report of the committee on the genetic constitution of autosomes other than chromosomes 1,2 and 6.
Frank H. Ruddle,P. Meera Khan +1 more
Journal ArticleDOI
Post-transplant renal function in the first year predicts long-term kidney transplant survival
Sundaram Hariharan,Maureen A. McBride,Wida S. Cherikh,Christine B. Tolleris,Barbara A. Bresnahan,Christopher P. Johnson +5 more
TL;DR: Recent improvements in graft half-life are related to conservation of renal function within the first year post-transplantation, and one-year creatinine and Delta Creatinine values predict long-term renal graft survival.
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