Journal ArticleDOI
Possible physiological role of adrenal and gonadal steroids in morphine analgesia.
TLDR
Results of the present study indicate that morphine subsensitivity after castration or supersensitivity after adrenalectomy may be attributed to the relative lack of testosterone or mineralocorticoid in the respective conditions.About:
This article is published in European Journal of Pharmacology.The article was published on 1982-01-22. It has received 51 citations till now. The article focuses on the topics: Adrenalectomy & Morphine.read more
Citations
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Journal ArticleDOI
Sex differences in pain and analgesia: the role of gonadal hormones.
TL;DR: An overview of gonadal steroid modulation of pain and analgesia in animals and humans is presented to describe mechanisms by which males' and females' biology may differentially predispose them to pain and to analgesic effects of drugs and stress.
Journal ArticleDOI
Gender differences in the responses to noxious stimuli
TL;DR: In this article, the authors take the position that females exhibit greater sensitivity to noxious stimuli than males and present a schematic model of several systems involved in the transmission and modulation of nociceptive information, which may contribute to gender-associated differences in pain sensitivity.
Journal ArticleDOI
Roles of gender, gonadectomy and estrous phase in the analgesic effects of intracerebroventricular morphine in rats.
TL;DR: Although female rats in either proestrous or estrous displayed significantly greater magnitude of analgesia than ovariectomized rats or rats in a combined met-/di-estrous phase at some doses, the ED50 of morphine analgesia was not significantly altered as functions of estrous phase or ovariectomy.
Journal ArticleDOI
Gender differences in opioid-mediated analgesia: animal and human studies.
TL;DR: Findings from the increasing number of wellcontrolled animal and human studies directly examining the issue of sex in the potency of opioids show that patient sex may impact on the clinical efficacy of opioids for pain.
Journal ArticleDOI
Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats.
TL;DR: In adult rats, gonadal steroid manipulations modulate basal nociception in females but not males, and morphine's antinociceptive potency in both males and females is demonstrated.
References
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A simplified method of evaluating dose-effect experiments.
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data.
Journal Article
A simplified method of evaluating dose-effect experiments
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: In this article, a rapid graphic method for approximating the median effective dose and the slope of dose-per-cent effect curves is presented, and confidence limits of both of these parameters for 19/20 probability are given by the method.
Journal Article
A method for determining loss of pain sensation
Fred E. D'Amour,Donn L. Smith +1 more
TL;DR: A simple, rapid method for determining the pain threshold in the rat was applied to the determination of analgesic properties of several substances, including cobra venom, where no analgesic property in the latter could be demonstrated.
Journal ArticleDOI
beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland
Roger Guillemin,Therese Vargo,Jean Rossier,Scott Minick,Nicholas Ling,Catherine Rivier,Wylie Vale,Floyd E. Bloom +7 more
TL;DR: Both hormones possess common and identical regulatory mechanisms and there may be a functional role for circulating beta-endorphin in response to acute stress or long-term adrenalectomy.