Journal ArticleDOI
Pre-eclampsia: more than pregnancy-induced hypertension.
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This article is published in The Lancet.The article was published on 1993-06-05. It has received 1221 citations till now. The article focuses on the topics: Preeclampsia & Eclampsia.read more
Citations
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A reversible posterior leukoencephalopathy syndrome
Judy Hinchey,Claudia Chaves,B A Appignani,Joan Breen,Linda Pao,Annabel Wang,Michael S. Pessin,Catherine Lamy,Jean-Louis Mas,Louis R. Caplan +9 more
TL;DR: Reversible, predominantly posterior leukoencephalopathy may develop in patients who have renal insufficiency or hypertension or who are immunosuppressed and the findings on neuroimaging are characteristic of subcortical edema without infarction.
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Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial.
Douglas G. Altman,Guillermo Carroli,Lelia Duley,Barbara Farrell,Jack Moodley,James P Neilson,David J. Smith +6 more
TL;DR: Magnesium sulphate halves the risk of eclampsia, and probably reduces therisk of maternal death, and there do not appear to be substantive harmful effects to mother or baby in the short term.
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Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
Susan E. Hiby,James J. Walker,Kevin M. O'Shaughnessy,Christopher W.G. Redman,Mary Carrington,John Trowsdale,Ashley Moffett +6 more
TL;DR: In this article, the authors tested the idea that recognition of these molecules by killer immunoglobulin receptors (KIRs) on maternal decidual NK cells is a key factor in the development of preeclampsia.
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Eclampsia in the United Kingdom
TL;DR: Eclampsia occurs in nearly one in 2000 maternities in the United Kingdom and is associated with high maternal morbidity and fatality in cases, and may present unheralded by warning signs.
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Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Gerd Wallukat,Volker Homuth,Thorsten Fischer,Carsten Lindschau,Björn Horstkamp,Axel Jüpner,Evi Baur,Eberhard Nissen,Klaus Vetter,Dajana Neichel,Joachim W. Dudenhausen,Hermann Haller,Friedrich C. Luft +12 more
TL;DR: It is suggested that preeclamptic patients develop stimulatory autoantibodies against the second extracellular AT1 receptor loop, which appears to be PKC-mediated and may participate in the angiotensin II-induced vascular lesions in these patients.
References
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Journal ArticleDOI
Preeclampsia: an endothelial cell disorder.
James M. Roberts,Robert N. Taylor,Thomas J. Musci,George M. Rodgers,Carl A. Hubel,Margaret K. McLaughlin +5 more
TL;DR: It is proposed that poorly perfused placental tissue releases a factor(s) into the systemic circulation that injuries endothelial cells and set in motion a dysfunctional cascade of coagulation, vasoconstriction, and intravascular fluid redistribution that results in the clinical syndrome of preeclampsia.
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Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants.
TL;DR: Findings point to a defect in the normal interaction between migratory trophoblast and maternal uterine tissues in pre‐eclampsia and in SGA, a feature not seen beyond the second trimester in normal pregnancy.
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A Study of Angiotensin II Pressor Response throughout Primigravid Pregnancy
TL;DR: In both groups, vascular resistance to infused angiotensin II (more than 8 ng/kg/min required to elicit a pressor response of 20 mm Hg in diastolic pressure) was demonstrated as early as the 10th wk of pregnancy, with a clear separation of the two groups by the 22nd wk.
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National High Blood Pressure Education Program Working Group report on hypertension in diabetes.
TL;DR: There has been an increased awareness of the importance of flexibility in the use of antihypertensive drugs as well as a refinement of nonpharmacologic approaches in treating people with both hypertension and diabetes.