Journal ArticleDOI
Predicting anastomotic leak: Can we?
TLDR
Identifying risk factors may assist the surgeon in mitigation of risk with preoperative optimization, intraoperative decision-making for diversion, and heightened postoperative vigilance for anastomotic leak.About:
This article is published in Seminars in Colon and Rectal Surgery.The article was published on 2014-06-01. It has received 4 citations till now.read more
Citations
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Journal ArticleDOI
The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses
TL;DR: The microbiome, the host genetic make‐up and their relationship to the perioperative inflammatory status are linked with various states of health and disease and in combining these three aspects in the case of postoperative recovery from bowel resection, the authors may be nearer an answer to preventing anastomotic leaks than might have been thought just a few years ago.
Journal ArticleDOI
Systematic Review on the Influence of Tissue Oxygenation on Gut Microbiota and Anastomotic Healing.
Samwel Makanyengo,Samwel Makanyengo,Georgia M. Carroll,Bridie J. Goggins,Stephen R. Smith,Peter Pockney,Simon Keely +6 more
TL;DR: Tissue oxygenation influences gut anastomotic healing, but little evidence exists to demonstrate the influence on the gut microbiome in the context of healing, and further studies are needed to determine if anastOMotic microbiome changes with altered tissue oxygenation and if this affects healing and leak rates.
Journal ArticleDOI
Towards interpretable, medically grounded, EMR-based risk prediction models
Isabell Twick,Guy Zahavi,Haggai Benvenisti,Ronya Rubinstein,M S Woods,Haim Berkenstadt,Aviram Nissan,Enes Hosgor,Dan Assaf +8 more
TL;DR: In this article , the authors use the example of risk assessment for postoperative complications to demonstrate how explainable and medically grounded risk prediction models can be developed, and show that these models have similar predictive performance as models that incorporate a wider range of inputs and explain the models' decision-making process.
The triune of intestinal microbiome, genetics and inflammatory status and its impact on lower gastrointestinal anastomosis healing
TL;DR: The microbiome, the host genetic makeup, and their relationship to the peri-operative inflammatory status are detailed, believing that in combining these three aspects in the case of post-operative recovery from bowel resection, the authors may be nearer an answer to preventing anastomotic leaks than might have been thought just a few years ago.
References
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Journal ArticleDOI
A comparison of laparoscopically assisted and open colectomy for colon cancer.
Heidi Nelson,Daniel J. Sargent,H Sam Wieand,James W. Fleshman,Mehran Anvari,Steven J. Stryker,Robert W. Beart,Michael D. Hellinger,Richard Flanagan,Walter R. Peters,David M. Ota +10 more
TL;DR: In this multi-institutional study, the rates of recurrent cancer were similar after laparoscopically assisted colectomy and open-colectomy, suggesting that the laparoscopic approach is an acceptable alternative to open surgery for colon cancer.
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Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial
Pierre J. Guillou,Philip Quirke,H. Thorpe,J. Walker,David G. Jayne,Adrian Smith,Richard M. Heath,Julia Brown +7 more
TL;DR: Laroscopic-assisted surgery for cancer of the colon is as effective as open surgery in the short term and is likely to produce similar long-term outcomes, however, impaired short- term outcomes after laparosc-assisted anterior resection forcancer of the rectum do not yet justify its routine use.
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Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial.
TL;DR: The restricted perioperative intravenous fluid regimen aiming at unchanged body weight reduces complications after elective colorectal resection.
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Risk factors for anastomotic leakage after resection of rectal cancer
TL;DR: The aim of this retrospective study was to evaluate the risk factors for clinical anastomotic leakage after anterior resection for cancer of the rectum.