Journal ArticleDOI
Pregnancy, Delivery, and Neonatal Complications in a Population Cohort of Women With Schizophrenia and Major Affective Disorders
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TLDR
While genetic liability and gene-environment interactions may account for some outcomes, maternal risk factors and biological and behavioral concomitants of severe mental illness appear to be major determinants of increases in reproductive pathology in this cohort.Abstract:
OBJECTIVE: This study ascertained the incidence of complications during pregnancy, labor, and delivery and the neonatal characteristics of infants born to women with schizophrenia, bipolar disorder, or major depression in a population-based cohort. METHOD: Based on records linkage across a psychiatric case register and prospectively recorded obstetric data, the study comprised women with schizophrenia or major affective disorders who had given birth to 3,174 children during 1980–1992 in Western Australia. A comparison sample of 3,129 births to women without a psychiatric diagnosis was randomly selected from women giving birth during 1980–1992. Complications were scored with the McNeil-Sjostrom Scale. Odds ratios were calculated for specific reproductive events. RESULTS: Both schizophrenic and affective disorder patients had increased risks of pregnancy, birth, and neonatal complications, including placental abnormalities, antepartum hemorrhages, and fetal distress. Women with schizophrenia were significan...read more
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Journal ArticleDOI
No health without mental health.
Martin Prince,Vikram Patel,Shekhar Saxena,Mario Maj,Joanna Maselko,Michael R. Phillips,Atif Rahman +6 more
TL;DR: Mental health affects progress towards the achievement of several Millennium Development Goals, such as promotion of gender equality and empowerment of women, reduction of child mortality, improvement of maternal health, and reversal of the spread of HIV/AIDS.
Journal ArticleDOI
The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: Retrospective analysis of population based registers
TL;DR: The gap in their life expectancy compared with the general population has widened since 1985 and public efforts should be directed towards improving physical health to reduce mortality in people with mental illness, in addition to ongoing efforts to prevent suicide.
Journal ArticleDOI
Physical illness and schizophrenia: a review of the literature
TL;DR: The lifespan of people with schizophrenia is shortened compared to the general population, and the literature on comorbid physical diseases in schizophrenia to provide a basis for initiatives to fight this unacceptable situation.
Journal ArticleDOI
Prenatal depression effects on the fetus and newborn : a review
TL;DR: Newborns of depressed mothers show a biochemical/physiological profile that mimics their mothers' prenatal biochemical/ Physiological profile including elevated cortisol, lower levels of dopamine and serotonin, greater relative right frontal EEG activation and lower vagal tone.
Journal ArticleDOI
Intellectual disability co-occurring with schizophrenia and other psychiatric illness: population-based study
TL;DR: The facility to combine records across administrative jurisdictions has enhanced the understanding of the epidemiology of dual diagnosis, its clinical manifestations and aetiological implications, and results are suggestive of a common pathogenesis in intellectual disability co-occurring with schizophrenia.
References
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A Polydiagnostic Application of Operational Criteria in Studies of Psychotic Illness: Development and Reliability of the OPCRIT System
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Congenital Heart Disease in 56,109 Births Incidence and Natural History
TL;DR: Within a prospective study of 56,109 total births, 457 youngsters have been found to have congenital heart disease, and essentially equal numbers of blacks and whites had all types of coarctation of the aorta in line with the study population, which is 47% black and 53% white.
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Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review
TL;DR: Current methods of investigating the relationship between obstetric complications and schizophrenia are reaching the limit of their usefulness, and a combination of disciplines and approaches will be needed to elucidate the mechanisms underlying these small but important associations.
Journal ArticleDOI
Population-based linkage of health records in Western Australia: development of a health services research linked database.
TL;DR: The Western Australian Health Services Research Linked Database is introduced as infrastructure to support aetlologic, utilisation and outcomes research and to compare the study population, data resources, technical systems and organisational supports with international best practice.