Journal ArticleDOI
Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy
Mireia Gascon,Maribel Casas,Eva Morales,Damaskini Valvi,Ana Ballesteros-Gómez,Noelia Luque,Soledad Rubio,Núria Monfort,Rosa Ventura,David Martinez,Jordi Sunyer,Martine Vrijheid +11 more
TLDR
Prenatal exposure to BPA and high-molecular-weight phthalates might increase the risk of asthma symptoms and respiratory tract infections throughout childhood.Abstract:
Background There is growing concern that prenatal exposure to bisphenol A (BPA) and phthalates, which are widely used in consumer products, might affect susceptibility to infections and the development of allergy and asthma in children, but there are currently very few prospective studies. Objective We sought to evaluate whether prenatal exposure to BPA and phthalates increases the risk of respiratory and allergic outcomes in children at various ages from birth to 7 years. Methods We measured BPA and metabolites of high-molecular-weight phthalates, 4 di-(2-ethylhexyl) phthalate (DEHP) metabolites (Σ 4 DEHP) and mono-benzyl phthalate (MBzP), and 3 low-molecular-weight phthalate (LMWP) metabolites (Σ 3 LMWP) in urine samples collected during the first and third trimesters in pregnant women participating in the Infancia y Medio Ambiente–Sabadell birth cohort study. The occurrence of chest infections, bronchitis, wheeze, and eczema in children was assessed at ages 6 and 14 months and 4 and 7 years through questionnaires given to the mothers. Atopy (specific IgE measurement) and asthma (questionnaire) were assessed at ages 4 and 7 years, respectively. Results The relative risks (RRs) of wheeze (RR, 1.20; 95% CI, 1.03-1.40; P = .02), chest infections (RR, 1.15; 95% CI, 1.00-1.32; P = .05), and bronchitis (RR, 1.18; 95% CI, 1.01-1.37; P = .04) at any age increased for each doubling in concentration of maternal urinary BPA. Σ 4 DEHP metabolites were associated with the same outcomes (wheeze: RR, 1.25; 95% CI, 1.04-1.50, P = .02; chest infections: RR, 1.15; 95% CI, 0.97-1.35; P = .11; bronchitis: RR, 1.20; 95% CI, 1.01-1.43; P = .04). MBzP was associated with higher risk of wheeze (RR, 1.15; 95% CI, 1.00-1.33; P = .05). The risk of asthma at age 7 years was also increased with increasing prenatal BPA, Σ 4 DEHP, and MBzP exposure. There were no other exposure-outcome associations. Conclusions Prenatal exposure to BPA and high-molecular-weight phthalates might increase the risk of asthma symptoms and respiratory tract infections throughout childhood.read more
Citations
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Journal ArticleDOI
Phthalates impact human health: Epidemiological evidences and plausible mechanism of action.
Sailas Benjamin,Sailas Benjamin,Eiji Masai,Naofumi Kamimura,Kenji Takahashi,Robin C. Anderson,Panichikkal Abdul Faisal +6 more
TL;DR: This clinically focused comprehensive review on the hazards of phthalates would benefit the general population, academia, scientists, clinicians, environmentalists, and law or policy makers to decide upon whether usage ofphthalates to be continued swiftly without sufficient deceleration or regulated by law or to be phased out from earth forever.
Journal ArticleDOI
A Review of Biomonitoring of Phthalate Exposures
TL;DR: This review compiles biomonitoring studies of phthalates and exposure doses to assess health risks from phthalate exposures in populations across the globe.
Journal ArticleDOI
The adverse health effects of bisphenol A and related toxicity mechanisms.
Ya Ma,Haohao Liu,Jinxia Wu,Le Yuan,Yueqin Wang,Xingde Du,Rui Wang,Phelisters Wegesa Marwa,Pavankumar Petlulu,Xinghai Chen,Huizhen Zhang +10 more
TL;DR: The underlying mechanisms of BPA-induced multi-organ toxicity were well summarized, involving the receptor pathways, disruption of neuroendocrine system, inhibition of enzymes, modulation of immune and inflammatory responses, as well as genotoxic and epigenetic mechanisms.
Journal ArticleDOI
Environmental pollutants and child health-A review of recent concerns
TL;DR: There is now moderate evidence that certain chemicals of relatively recent concern may be associated with adverse child health outcomes, specifically perfluorooctanoate and foetal growth, and polybrominated diphenyl ethers and neurodevelopment.
Journal ArticleDOI
The effects of environmental chemicals on renal function
TL;DR: Environmental exposure to these chemicals during everyday life could have adverse consequences on renal function and might contribute to progressive cumulative renal injury over a lifetime, and regulatory efforts should be made to limit individual exposure to environmental chemicals in an attempt to reduce the incidence of cardiorenal disease.
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