Preparation of Acyclovir-Containing Solid Foam by Ultrasonic Batch Technology.
Ádám Haimhoffer,Ferenc Fenyvesi,Istvan Lekli,Monika Béresová,Istvan Bak,Máté Czagány,Gábor Vasvári,Ildikó Bácskay,Judit Tóth,István Budai +9 more
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TLDR
In this paper, a stable floating formulation of drugs by foaming has been developed, which can result in increased bioavailability of drugs and prolong the gastric residence time of drugs; therefore, drug release will be sustained.Abstract:
In recent years, the application of solid foams has become widespread. Solid foams are not only used in the aerospace field but also in everyday life. Although foams are promising dosage forms in the pharmaceutical industry, their usage is not prevalent due to decreased stability of the solid foam structure. These special dosage forms can result in increased bioavailability of drugs. Low-density floating formulations can also increase the gastric residence time of drugs; therefore, drug release will be sustained. Our aim was to produce a stable floating formula by foaming. Matrix components, PEG 4000 and stearic acid type 50, were selected with the criteria of low gastric irritation, a melting range below 70 °C, and well-known use in oral drug formulations. This matrix was melted at 54 °C in order to produce a dispersion of active substance and was foamed by different gases at atmospheric pressure using an ultrasonic homogenizer. The density of the molded solid foam was studied by the pycnometer method, and its structure was investigated by SEM and micro-CT. The prolonged drug release and mucoadhesive properties were proved in a pH 1.2 buffer. According to our experiments, a stable foam could be produced by rapid homogenization (less than 1 min) without any surfactant material.read more
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In Vitro and In Vivo Studies of a Verapamil-Containing Gastroretentive Solid Foam Capsule
Ádám Haimhoffer,Gábor Vasvári,István Budai,Monika Béresová,Adam Deak,Norbert Nemeth,Judit Váradi,Dávid Sinka,Ildikó Bácskay,Miklós Vecsernyés,Ferenc Fenyvesi +10 more
TL;DR: In this article, the authors presented verapamil-HCl-containing solid foam prepared by continuous manufacturing, and the foam structure was characterized by micro-CT scans and SEM.
Journal ArticleDOI
Recent Progress in Research of Solid Tritium Breeder Materials Li2TiO3: A Review
Kun Xu,Chao Qi,Boran Wang +2 more
TL;DR: Li2TiO3 can be synthesized by strategies such as solid-state, sol-gel, hydrothermal, solution combustion synthesis, and co-precipitation methods as mentioned in this paper .
Journal ArticleDOI
Polymeric Excipients in the Technology of Floating Drug Delivery Systems
E. V. Blynskaya,Sergey Tishkov,Vladimir Vinogradov,K. V. Alekseev,A.I. Marakhova,Alexandre A. Vetcher +5 more
TL;DR: In this paper , the most widely used groups of polymers, their properties, and their purpose in various technological approaches to achieving buoyancy have been determined, and ways to modify the release of APIs in these systems and the excipients used for this are described.
Journal ArticleDOI
Modern Approaches to Obtaining Floating Drug Dosage Forms (A Review)
Journal ArticleDOI
Optimization and In Vitro Characterization of Telmisartan Loaded Sodium Alginate Beads and Its In Vivo Efficacy Investigation in Hypertensive Induced Animal Model
Ubaidulla Uthumansha,Kousalya Prabahar,Dilli Bhai Gajapathy,Mohamed El-Sherbiny,Nehal M. Elsherbiny,Mona Qushawy +5 more
TL;DR: In this article , a central composite design was used for the formulation and optimization of seventeen formulations of TEL-loaded, oil-entrapped, floating alginate beads with the intent of enhancing the oral bioavailability of telmisartan for the treatment of hypertension.
References
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