Prevalence of transient congenital hypothyroidism among neonates
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In this article, the prevalence of transient congenital hypothyroidism among neonates in (XXX) was determined by a cross-sectional study, where neonates aged 3-5 days who were referred to their center for checkup were screened for thyroid stimulating hormone.Abstract:
Objective Persistence of low levels of thyroid hormone from the time of birth is one of the significant causes of the mental retardation. The aim of this study was to determine the prevalence of transient congenital hypothyroidism among neonates in (XXX). Methods This cross-sectional study, neonates aged 3–5 days who were referred to our center for checkup were screened for thyroid stimulating hormone. Those with TSH Results Of 3600 neonates screened, 126 were presented with had TSH above 5 mIU/l, of which 7 had high TSH and low T4 and were diagnosed with transient hypothyroidism (5.3%). The mean weight of the neonates with hypothyroidism of significantly lower, p = 0.001. However, the type of delivery was not associated with the prevalence of hypothyroidism, p = 0.999. The relationship between maternal hypothyroidism, preterm birth and intake of antithyroid drugs and transient hypothyroidism was statistically significant, p Conclusions The incidence of congenital hypothyroidism was 1 in 514 births and was significantly associated with preterm birth, mean weight, maternal hypothyroidism and intake of antithyroid drugs. Routine screening in high prevalence regions are therefore importance, considering the associated factors.read more
Citations
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Congenital Hypothyroidism in Preterm Newborns – The Challenges of Diagnostics and Treatment: A Review
TL;DR: This review summarizes the current state of knowledge on congenital hypothyroidism in preterm infants, discusses screening and treatment options, and demonstrates present challenges and controversies.
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Evaluation of the Clinical, Laboratory and Etiological Characteristics of the Patients with Congenital Hypothyroidism
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References
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Journal ArticleDOI
Update of Newborn Screening and Therapy for Congenital Hypothyroidism
Susan R. Rose,Rosalind S. Brown +1 more
TL;DR: Efforts are ongoing to establish the optimal therapy that leads to maximum potential for normal development for infants with congenital hypothyroidism, as well as to maintain frequent evaluations of total Thyroxine or free thyroxine in the upper half of the reference range during the first 3 years of life.
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STROCSS 2021: Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery
Ginimol Mathew,Riaz Agha,Joerg Albrecht,Prabudh Goel,Indraneil Mukherjee,Prathamesh S. Pai,Anil K. D'Cruz,Iain J. Nixon,Klappenbach Roberto,Syed Ather Enam,Somprakas Basu,Oliver J. Muensterer,Salvatore Giordano,Duilio Pagano,David Machado-Aranda,Patrick J. Bradley,Mohammad Bashashati,Achilles Thoma,Raafat Yahia Afifi,Maximilian J. Johnston,Ben Challacombe,James Chi Yong Ngu,Mushtaq Chalkoo,Kandiah Raveendran,Jerome R. Hoffman,Boris Kirshtein,Boris Kirshtein,Wan Yee Lau,Mangesh A. Thorat,Mangesh A. Thorat,Diana Miguel,Andrew J. Beamish,Gaurav Roy,Donagh Healy,M. Hammad Ather,Shahzad G. Raja,Zubing Mei,Todd G Manning,Veeru Kasivisvanathan,Juan Gómez Rivas,Roberto Coppola,Burcin Ekser,Veena K.L. Karanth,Huseyin Kadioglu,Michele Valmasoni,Ashraf Noureldin +45 more
TL;DR: In order to maintain relevance and continue upholding good reporting quality among observational studies in surgery, this paper aimed to update STROCSS 2019 guidelines, which were developed in 2017 and updated in 2019.
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A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate.
Mireille Castanet,Soo-Mi Park,Aaron G. Smith,Michel Bost,Juliane Léger,Stanislas Lyonnet,Anna Pelet,Paul Czernichow,Krishna Chatterjee,Michel Polak +9 more
TL;DR: The observations support the role of TTF-2 in both thyroid and palate development but suggest phenotypic heterogeneity of this syndromic form of CH, which may account for the absence of choanal atresia and bifid epiglottis in patients.
Journal ArticleDOI
Screening for Congenital Hypothyroidism: The Significance of Threshold Limit in False-Negative Results
Chryssanthi Mengreli,Christina Kanaka-Gantenbein,Panagiotis Girginoudis,Maria-Alexandra Magiakou,Ioulia Christakopoulou,Aglaia Giannoulia-Karantana,George P. Chrousos,Catherine Dacou-Voutetakis +7 more
TL;DR: A significant number of cases with permanent CH are missed when a TSH threshold of 20 mU/liter is applied and the increase in recall rate constitutes a serious drawback and should be balanced against the possible consequences of thyroid dysfunction at this important developmental stage.
Journal ArticleDOI
Risk factors for congenital hypothyroidism: results of a population case-control study (1997-2003).
Emanuela Medda,Antonella Olivieri,Maria Antonietta Stazi,Michele E. Grandolfo,Cristina Fazzini,Mariangiola Baserga,Massimo Burroni,Emanuele Cacciari,Francesca Calaciura,Alessandra Cassio,Luca Chiovato,Pietro Costa,Daniela Leonardi,Maria Martucci,Lidia Moschini,Severo Pagliardini,Giuseppe Parlato,Alberto Pignero,Aldo Pinchera,Danielle Sala,Lidia Sava,Vera Stoppioni,Francesco Tancredi,Fabiola Valentini,Riccardo Vigneri,Mariella Sorcini +25 more
TL;DR: The results suggested a multifactorial origin of CH in which genetic and environmental factors play a role in the development of the disease.