Principles of protein-protein interactions.
Sarah A. Teichmann
- Vol. 18, pp 249-249
TLDR
Property such as sequence conservation and co-regulation of genes and proteins involved in different types of physical interactions are discussed, given that all proteins consist of their evolutionary units, the domains, all interactions occur between these domains.Abstract:
In the postgenomic era, one of the most interesting and important challenges is to understand protein interactions on a large scale. The physical interactions between protein domains are fundamental to the workings of a cell: in multi-domain polypeptide chains, in multi-subunit proteins and in transient complexes between proteins that also exist independently. Thus experimental investigation of protein-protein interactions has been extensive, including recent large-scale screens using mass spectrometry. The role of computational research on protein-protein interactions encompasses not only prediction, but also understanding the nature of the interactions and their three-dimensional structures. I will discuss properties such as sequence conservation and co-regulation of genes and proteins involved in different types of physical interactions. Given that all proteins consist of their evolutionary units, the domains, all interactions occur between these domains. The interactions between domains belonging to different protein families will be the second topic of my talk.read more
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Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
TL;DR: These studies discovered small molecules that bind with drug-like potencies to 'hotspots' on the contact surfaces involved in protein–protein interactions, and bind with much higher efficiencies than do the contact atoms of the natural protein partner.
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Water mediation in protein folding and molecular recognition
Yaakov Levy,José N. Onuchic +1 more
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High-affinity binders selected from designed ankyrin repeat protein libraries.
H. Kaspar Binz,Patrick Amstutz,Andreas Kohl,Michael T. Stumpp,Christophe Briand,Patrik Forrer,Markus G. Grütter,Andreas Plückthun +7 more
TL;DR: The evolution of ankyrin repeat (AR) proteins in vitro for specific, high-affinity target binding and combinatorial libraries of AR proteins of varying repeat numbers with diversified binding surfaces are generated, an attractive alternative to antibody libraries.
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Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains
Jannik N. Andersen,Ole Hartvig Mortensen,Günther H.J. Peters,Paul G. Drake,Lars Fogh Iversen,Ole Hvilsted Olsen,Peter Gildsig Jansen,Henrik Sune Andersen,Nicholas K. Tonks,Niels Møller +9 more
TL;DR: A comparative analysis of the structural relationships among vertebrate PTP domains is presented and a comprehensive resource for sequence analysis of phosphotyrosine-specific PTPs is provided.