Journal ArticleDOI
Privileged Chiral Catalysts
Tehshik P. Yoon,Eric N. Jacobsen +1 more
TLDR
Drawing inspiration from natural catalysts, chemists have developed a variety of synthetic small-molecule catalysts that can achieve levels of selectivity approaching, and in some cases matching, those observed in enzymatic reactions.Abstract:
One of the most active current areas of chemical research is centered on how to synthesize handed (chiral) compounds in a selective manner, rather than as mixtures of mirror-image forms (enantiomers) with different three-dimensional structures (stereochemistries). Nature points the way in this endeavor: different enantiomers of a given biomolecule can exhibit dramatically different biological activities, and enzymes have therefore evolved to catalyze reactions with exquisite selectivity for the formation of one enantiomeric form over the other. Drawing inspiration from these natural catalysts, chemists have developed a variety of synthetic small-molecule catalysts that can achieve levels of selectivity approaching, and in some cases matching, those observed in enzymatic reactions.read more
Citations
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Journal ArticleDOI
Homochiral Metal–Organic Frameworks for Asymmetric Heterogeneous Catalysis
Journal ArticleDOI
Comparison of the Abilities of Ambient and Manufactured Nanoparticles To Induce Cellular Toxicity According to an Oxidative Stress Paradigm
Tian Xia,Michael Kovochich,Jonathan A. Brant,Matt Hotze,Joan M. Sempf,Terry Oberley,Constantinos Sioutas,Joanne I. Yeh,Mark R. Wiesner,Andre E. Nel +9 more
TL;DR: It is demonstrated that ROS generation and oxidative stress are a valid test paradigm to compare NP toxicity, and particle interactions with cellular components are capable of generating oxidative stress.
Journal ArticleDOI
Metal–Salen Schiff base complexes in catalysis: practical aspects
TL;DR: Practical guidelines for the preparation and use of different Schiff base metal complexes in the field of catalytic transformations are discussed in this tutorial review.
Journal ArticleDOI
Asymmetric catalysis by chiral hydrogen-bond donors.
Mark S. Taylor,Eric N. Jacobsen +1 more
TL;DR: This review documents the structural and mechanistic features that contribute to high enantioselectivity in hydrogen-bond-mediated catalytic processes in small-molecule, synthetic catalyst systems.
Journal ArticleDOI
Synthesis of cyclic carbonates from epoxides and CO2
TL;DR: In this article, the synthesis of cyclic carbonates by the 100% atom economical reaction between epoxides and CO2 is reviewed in the context of reducing global emissions of waste CO 2 and converting waste CO2 into industrially useful chemical feedstocks.
References
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Catalytic Asymmetric Dihydroxylation
Journal ArticleDOI
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
Ben E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,George F. Lundell,Daniel F. Veber,Paul S. Anderson,Raymond S.L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,Paul J. Kling,K. A. Kunkel,James P. Springer,J. Hirshfield +16 more
TL;DR: 3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.
Journal ArticleDOI
Asymmetric Catalysis with Water: Efficient Kinetic Resolution of Terminal Epoxides by Means of Catalytic Hydrolysis
TL;DR: This work has shown that kinetic resolution is an attractive strategy for the production of optically active epoxides, given an economical and operationally simple method.
Journal ArticleDOI
Asymmetric catalysis of epoxide ring-opening reactions.
TL;DR: A search for a practical method for the kinetic resolution reaction led to the discovery of highly enantiomer-selective hydrolytic ring-opening using the corresponding (salen)Co(III) catalyst, which displays extraordinary substrate generality, and allows practical access to enantiopure terminal epoxides on both laboratory and industrial scales.