Journal ArticleDOI
Process control and scale-up of pharmaceutical wet granulation processes: a review.
A. Faure,Peter York,Ray C. Rowe +2 more
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TLDR
For wet granulation in high-shear mixers, specific methods based on the liquid saturation and the consistency of the wet mass are described and engineering techniques based on particle size population balance modelling are under development for both fluid bed and high- shear granulation.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2001-11-01. It has received 308 citations till now. The article focuses on the topics: Fluid Bed Granulation & Granulation.read more
Citations
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Microencapsulation of probiotics for gastrointestinal delivery.
TL;DR: An overview of progress in this field is provided as well as drawing attention to areas where studies have fallen short, followed by a discussion of emerging trends in the field, highlighting key areas in which further research is necessary.
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Near-infrared spectroscopy applications in pharmaceutical analysis
TL;DR: Recent developments in the pharmaceutical domain where NIR spectroscopy can be applied from raw material identification to final product release are reviewed.
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Artificial intelligence in drug discovery and development.
TL;DR: This review highlights the impactful use of AI in diverse areas of the pharmaceutical sectors viz., drug discovery and development, drug repurposing, improving pharmaceutical productivity, clinical trials, etc, thus reducing the human workload as well as achieving targets in a short period.
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3D Printing technologies for drug delivery: a review
TL;DR: The 3D printing technologies being utilized for the fabrication of drug delivery systems, as well as the formulation and processing parameters for consideration, are highlighted and the range of dosage forms prepared using these technologies, specifically over the last 10 years are summarized.
Journal ArticleDOI
Process systems modelling and applications in granulation: A review
TL;DR: Improved mathematical representations, new solution techniques and the application of the models to industrial processes are yielding better designs, improved optimisation and tighter control of these systems.
References
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Journal ArticleDOI
A microlevel-based characterization of granulation phenomena
TL;DR: A classification of granulation mechanisms based on the collisional dissipation of relative particle kinetic energy and binder viscosity is introduced and Fluid-bed granulation and defluidization experiments supporting this simple classification ofgranulation regimes are presented.
Journal ArticleDOI
Adjustable discretized population balance for growth and aggregation
TL;DR: In this article, the authors extended the discretized population balance (DPB) of Hounslow et al. (1988) to allow the use of an adjustable discretization of the size domain of the form νi+/ν1=2 1/q (where q ≥ 1 and is an integer).
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Growth regime map for liquid-bound granules
S.M. Iveson,James D. Litster +1 more
TL;DR: In this paper, a regime map of granule growth behavior is proposed based on granule deformation during collision and the granule liquid content measured as the maximum pore saturation.
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Process control and end-point determination of a fluid bed granulation by application of near infra-red spectroscopy
TL;DR: In this paper, the authors used in-line near infra-red spectroscopy (NIRS) to obtain granule moisture content and particle size change data, allowing modification of process conditions if required and end-point identification.
Journal ArticleDOI
Granulation: A Review on Pharmaceutical Wet-Granulation
TL;DR: In this article, a review of recent developments in pharmaceutical wet granulation techniques is presented with the main emphasis on granulation in fluidized beds and high shear mixers, and the following items are dealt with: Fundamentals of granule growth, granulation methods and equipments, granulations variables, scaling-up and end-point control.