Journal ArticleDOI
Production of 2,3-butanediol from D-xylose by Klebsiella oxytoca ATCC 8724.
TLDR
The effects of pH, xylose concentration, and the oxygen transfer rate on the bioconversion of D‐xylose to 2,3‐butanediol are described.Abstract:
It is known that 2,3-butanediol is a potentially valuable chemical feedstock that can be produced from the sugars present in hemicellulose and celluose hydrolysates. Klebsiella oxytoca is able to ferment most pentoses, hexoses, and disaccharides. Butanediol appears to be a primary metabolite, excreted as a product of energy methabolism. The theoretical maximum yield of butanediol from monosaccharides is 0.50 g/g. This article describes the effects of pH, xylose concentration, and the oxygen transfer rate on the bioconversion of D-xylose to 2,3-butanediol. Product inhibition by butanediol is also examined. The most important variable affecting the kinetics of this system appears to be the oxygen transfer rate. A higher oxygen supply favors the formation of cell mass at the expense of butanediol. Decreasing the oxygen supply rate increases the butanediol yield, but decreases the overall conversion rate due to a lower cell concentration.read more
Citations
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Journal ArticleDOI
Hemicellulose bioconversion
TL;DR: In this article, various pre-treatment options as well as enzymatic saccharification of lignocellulosic biomass to fermentable sugars are reviewed and the barriers, progress, and prospects of developing an environmentally benign bioprocess for large-scale conversion of hemicellulose to fuel ethanol, xylitol, 2,3-butanediol, and other value added fermentation products are highlighted.
Journal ArticleDOI
Microbial 2,3-butanediol production: A state-of-the-art review
TL;DR: Various strategies for efficient and economical microbial 2,3-butanediol production, including strain improvement, substrate alternation, and process development, are reviewed and compared with regard to their pros and cons.
Journal ArticleDOI
Investigation of bacterial growth on mixed substrates: experimental evaluation of cybernetic models
TL;DR: Cybernetic models, developed earlier by the authors, have been evaluated experimentally for the growth of Klebsiella oxytoca in batch cultures using mixed substrates from glucose, xylose, arabinose, lactose, and fructose, accurately predicting the order in which the substrates are consumed.
Journal ArticleDOI
Fermentative production of 2,3-butanediol: A review
S.K. Garg,A. Jain +1 more
TL;DR: The production of 2,3-butanediol by bacterial species continues to be of great interest because of its varied application as discussed by the authors, and two bacterial species, Bacillus polymyxa and Klebsiella pneumoniae have demonstrated potential for butanediol fermentation on a commercial scale.
Book ChapterDOI
The Microbial Production of 2,3-Butanediol
R. J. Magee,N. Kosaric +1 more
TL;DR: This chapter provides a comprehensive survey of diol production, including biochemistry, microbiology, and process engineering, and Klebsiella pneumoniae, with broad substrate and environmental adaptability, is the most thoroughly investigated organism.
References
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Computer‐aided material balancing for prediction of fermentation parameters
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Journal ArticleDOI
Biomass as a source of chemical feedstocks: an economic evaluation.
TL;DR: It is suggested that the raw materials and technology exist for basing a major fraction of the U.S. chemical industry on four fermentation products, used in the proper portions: ethanol, isopropanol, n-butanol, and 2,3-butanediol.